BrainRegionLMC MM RP DRN

Dorsal Raphe Nucleus

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This page covers biological details of component Dorsal Raphe Nucleus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Midbrain Mesencephalon -> Mesencephalic Reticular Formation (MM.RF) -> Mesencephalic Reticular Formation, Midline Column (MM.RF.MID) -> Dorsal Raphe Nucleus (LMC.MM.RP.DRN) (see Mind Maps)
• Type: nucleus
• Quality: L0
• Brain area: Lower Brain - Modulatory Contol Area (LMC)
• Area circuit: Serotonin - Feelings of Well-Being and Happiness (5HT)
• Role: processor.autonomic
• Function: Regulation of sleep and mood
• Notes to function:
  • Major source of 5HT
  • inhibitory nucleus

(generated)

Components

(generated)

Component items:

• Serotonergic cell group B7

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Role	Reference
FAM	FAM.FD.LHB.MED	Lateral Habenula Medial Part	excitatory-glu	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)
FEC	FEC.HT.TG.IPD	Interpeduncular Nucleus	modulatory-ach	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> DRN)
	FEC.HT.TG.RMTG	Rostromedial Tegmental Nucleus	inhibitory-gaba	uncertain	Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> DRN)
LLC	LLC.FD.TH.SF	Subfascicular Nucleus of Thalamus	inhibitory-gaba	uncertain	(unknown reference)
LMC	LMC.HP.RP.LI	Raphe Nucleus Linearis	modulatory-5ht	uncertain	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Role	Reference
NDM	NDM.FD.TH.PV	Paraventricular Nucleus of Thalamus	modulatory-5ht	uncertain	(unknown reference)

Thirdparty Circuits

(generated)

• Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference (CF.HB-DA5HT)

DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN
GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT
LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED
LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
LS=Lateral Septal Nucleus,FAM.FT.SEP.LT
MHb=Medial Habenula,FAM.FD.MHB
MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
MS=Medial Septal Nucleus,FAM.FT.SEP.MED
PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei)
RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA

• Habenula Connections - see Reference (CF.HB-CONNECTIONS)

CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DR=Dorsal Raphe Nucleus,LMC.MM.RP.DRN
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
IP=Interpeduncular Nucleus,FEC.HT.TG.IPD
LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
LHb=Lateral Habenula,FAM.FD.LHB (see Habenula)
LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
MHb=Medial Habenula,FAM.FD.MHB
MR=Superior Central Raphe Nucleus,LMC.MM.RP.SUC
PB=Endocrine Glands,TARGET.TEA.ENDOCRINE
S=Septal Nuclei,FAM.FT.SEP
SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
VTA=Ventral Tegmental Area,LMC.MM.VTA

References

(generated)

• http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html
• http://www.scholarpedia.org/article/Habenula