BrainRegionLAC FD HT VLPO
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Ventrolateral Preoptic Nucleus
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This page covers biological details of component Ventrolateral Preoptic Nucleus. Region is part of aHuman target integrated biological model.
- Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Anterior Hypothalamus Area (LAC.FD.HT.AHT) -> Chiasmatic Area (LAC.FD.HT.CHS) -> Preoptic Nucleus (LAC.FD.HT.PO) -> Ventrolateral Preoptic Nucleus (LAC.FD.HT.VLPO) (see Mind Maps)
- Type: nucleus
- Quality: L0
- Brain area: Lower Brain - Autonomous Control Area (LAC)
- Area circuit: Autonomic Thermoregulation (LAT)
- Role: processor.autonomic
- Function: mediates non-REM sleep onset
- Notes to function:
- lesions in VLPO result in insomnia
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Components
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- no child items defined
Connectivity
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Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Role | Reference |
| FAM | FAM.FT.AM.MEA | Medial Anterior Amygdaloid Nucleus | excitatory-glu | uncertain | Role for serotonin in moral behavior (AMY -> HYP, abstract) |
| FAM.FT.SEP.LT | Lateral Septal Nucleus | inhibitory-gaba | uncertain | Cingulate Gyrus (SEP -> HT, abstract) | |
| FEC | FEC.HT.TG.RMTG | Rostromedial Tegmental Nucleus | inhibitory-gaba | uncertain | (unknown reference) |
| LAC | LAC.FD.HT.DM | Dorsomedial Hypothalamic Nucleus | excitatory-glu | uncertain | Eating and sleeping to survive (DMH -> VLPO) |
| LAC.FD.HT.SCN | Suprachiasmatic Nucleus | excitatory-glu | uncertain | (unknown reference) | |
| LAC.FD.HT.TBM | Tuberomammillary Nucleus | modulatory-hist | modulator | Simplified NREM sleep-promoting pathway (TMN -> VLPO) | |
| LAC.FD.HT.VM | Ventromedial Hypothalamic Nucleus | excitatory-glu | uncertain | (unknown reference) | |
| LMC | LMC.HT.LC | Locus Coeruleus | modulatory-ne | uncertain | Simplified NREM sleep-promoting pathway (LC -> VLPO) |
| NSA | NSA.NC.PH.PRP | Prepyriform Cortex | excitatory-glu | uncertain | (unknown reference) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Role | Reference |
| FAM | FAM.FD.LHB.LT | Lateral Habenula Lateral Part | excitatory-glu | uncertain | Habenula Connections (LPO -> LHb, abstract) |
| FAM.FD.LHB.MED | Lateral Habenula Medial Part | excitatory-glu | uncertain | Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM) | |
| LAC | LAC.FD.HT.SUM | Supramammillary Nucleus | excitatory-glu | uncertain | (unknown reference) |
| LMC | LMC.HT.TG.LDT | Laterodorsal Tegmental Nucleus | excitatory-glu | uncertain | Simplified NREM sleep-promoting pathway (VLPO -> LDTg) |
Thirdparty Circuits
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- Simplified NREM sleep-promoting pathway - see Reference (CL.TBM-PO)
LC=Locus Coeruleus,LMC.HT.LC LDTg=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT TMN=Tuberomammillary Nucleus,LAC.FD.HT.TBM VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
- Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference (CF.HB-DA5HT)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia) IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO LS=Lateral Septal Nucleus,FAM.FT.SEP.LT MHb=Medial Habenula,FAM.FD.MHB MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) MS=Medial Septal Nucleus,FAM.FT.SEP.MED PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei) RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA
- Habenula Connections - see Reference (CF.HB-CONNECTIONS)
CPu=Striatum,FEC.FT.ST (see Basal Ganglia) DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DR=Dorsal Raphe Nucleus,LMC.MM.RP.DRN GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia) IP=Interpeduncular Nucleus,FEC.HT.TG.IPD LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus) LHb=Lateral Habenula,FAM.FD.LHB (see Habenula) LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO MHb=Medial Habenula,FAM.FD.MHB MR=Superior Central Raphe Nucleus,LMC.MM.RP.SUC PB=Endocrine Glands,TARGET.TEA.ENDOCRINE S=Septal Nuclei,FAM.FT.SEP SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT VTA=Ventral Tegmental Area,LMC.MM.VTA
- Eating and sleeping to survive - see Reference (CP.DMH-CYCLES)
ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN MPO=Median Preoptic Nucleus,LAC.FD.HT.MPO PVH=Paraventricular Nucleus,LAC.FD.HT.PV SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM
References
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