BrainCenterHT TG

Pontine Tegmental Nuclei

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This page covers biological details of component group Pontine Tegmental Nuclei. Component group is part of aHuman target integrated biological model.

• Top-down path to center: Hindbrain Metencephalon -> Pontine Tegmental Nuclei (HT.TG) (see Mind Maps)
• Function:

(generated)

Components

(generated)

Component items:

• Incertus Nucleus (FAM.HT.TG.NI): Behavioural activation and the response to stress
• Dorsal Tegmental Nucleus (LMC.HT.TG.DTG): accurate landmark navigation
• Laterodorsal Tegmental Nucleus (LMC.HT.TG.LDT): Modulating sustained attention or in mediating alerting responses
• Pedunculopontine Tegmental Nuclei (HT.TG.PPN): Provide sensory feedback to cerebral cortex; modulatory
  • Rostromedial Tegmental Nucleus (FEC.HT.PPN.RMTG): locomotion - walking, running
  • Interpeduncular Nucleus (FEC.HT.PPN.IPD): postural control, voluntary arm and eye movements

Connectivity

(generated)

Internal Regions Connections:

Source Region	Target Region	Reference
Interpeduncular Nucleus (FEC.HT.PPN.IPD)	Dorsal Tegmental Nucleus (LMC.HT.TG.DTG)	Head Direction Cell Circuit (IPD -> DTN)
Rostromedial Tegmental Nucleus (FEC.HT.PPN.RMTG)	Interpeduncular Nucleus (FEC.HT.PPN.IPD)	(unknown reference)
	Laterodorsal Tegmental Nucleus (LMC.HT.TG.LDT)	(unknown reference)
Laterodorsal Tegmental Nucleus (LMC.HT.TG.LDT)	Interpeduncular Nucleus (FEC.HT.PPN.IPD)	(unknown reference)

External Connections:

External Inbound Center Connections:

Source Center	Sample Link	Reference
Habenula (FAM.FD.HB)	FAM.FD.LHB.MED -> FAM.HT.TG.NI	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> NI)
Hypothalamus (FD.HT)	LAC.FD.HT.VLPO -> LMC.HT.TG.LDT	Simplified NREM sleep-promoting pathway (VLPO -> LDTg, abstract)
Sensory Thalamus (FD.TH.SR)	NSA.FD.TH.SG -> LMC.HT.TG.LDT	(unknown reference)
Subthalamus Area (FEC.FD.STA)	FEC.FD.STN.ICD -> FEC.HT.PPN.IPD	(unknown reference)
Basal Ganglia (FEC.FT.BG)	FEC.FT.SNR.MED -> FEC.HT.PPN.IPD	(unknown reference)
Myelencephalic Motor Nuclei (HL.MN)	LRC.HL.NPH -> LMC.HT.TG.DTG	(unknown reference)
Pontine Reticular Formation (HT.RF)	LRC.HT.PRF.RPO -> FAM.HT.TG.NI	(unknown reference)
Locus Coeruleus (LMC.HT.LC)	LMC.HT.LC -> FEC.HT.PPN.IPD	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)

External Outbound Center Connections:

Target Center	Sample Link	Reference
Central Extended Amygdala (FAM.FT.CEAM)	FAM.HT.TG.NI -> FAM.FT.EPF	(unknown reference)
Septal Nuclei (FAM.FT.SEP)	FAM.HT.TG.NI -> FAM.FT.SEP.SF	(unknown reference)
Hypothalamus (FD.HT)	FEC.HT.PPN.RMTG -> LAC.FD.HT.VLPO	(unknown reference)
Sensory Thalamus (FD.TH.SR)	FEC.HT.PPN.IPD -> NSA.FD.LGN	Geniculate and Extyrageniculate Paths (PPN -> LGN, abstract)
Subthalamus Area (FEC.FD.STA)	FEC.HT.PPN.IPD -> FEC.FD.STN.LT	(unknown reference)
Basal Ganglia (FEC.FT.BG)	FEC.HT.PPN.IPD -> FEC.FT.SNC.LT	Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> SNc, abstract)
Hippocampal Formation (FMM.FT.HF)	FEC.HT.PPN.IPD -> FMM.FT.HC.CA3P	Connectivity map of the habenula (IPN -> Hippo, abstract)
Myelencephalic Motor Nuclei (HL.MN)	LMC.HT.TG.LDT -> LRC.HL.NPH	(unknown reference)
Myelencephalic Parasympathetic Nuclei (HL.PSN)	LMC.HT.TG.LDT -> LAC.HL.SAL.ISL	(unknown reference)
Medullary Reticular Formation (HL.RF)	FEC.HT.PPN.IPD -> LMC.HL.RP.MG	Connectivity map of the habenula (IPN -> Raphe, abstract)
Periaqueductal Gray Matter (LMC.MM.PAG)	FEC.HT.PPN.IPD -> LMC.MM.PAG	Connectivity map of the habenula (IPN -> PAG)
Ventral Tegmental Area (LMC.MM.VTA)	FEC.HT.PPN.IPD -> LMC.MM.VTA	Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> VTA)
Reflexes Nuclei of Midbrain Mesencephalon (MM.REF)	FEC.HT.PPN.IPD -> LRC.MM.SC.INT	Geniculate and Extyrageniculate Paths (PPN -> SC, abstract)
Mesencephalic Reticular Formation (MM.RF)	FEC.HT.PPN.IPD -> LMC.MM.RP.DRN	Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> DRN)
Rhinal Cortex (NC.PHA.RH)	FAM.HT.TG.NI -> FMM.NC.PH.PER	(unknown reference)