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Ventrolateral Preoptic Nucleus

@@Home -> BiologicalLifeResearch -> BrainAreaLAC -> BrainRegionLAC_FD_HT_VLPO

This page covers biological details of component Ventrolateral Preoptic Nucleus. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Anterior Hypothalamus Area (LAC.FD.HT.AHT) -> Chiasmatic Area (LAC.FD.HT.CHS) -> Preoptic Nucleus (LAC.FD.HT.PO) -> Ventrolateral Preoptic Nucleus (LAC.FD.HT.VLPO) (see Mind Maps)
  • Type: nucleus
  • Quality: L0
  • Brain area: Lower Brain - Autonomous Control Area (LAC)
  • Area circuit: Autonomic Thermoregulation (LAT)
  • Role: processor.autonomic
  • Function: mediates non-REM sleep onset
  • Notes to function:
    • lesions in VLPO result in insomnia




  • no child items defined



Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FT.AM.MEA Medial Anterior Amygdaloid Nucleus excitatory-glu uncertain Role for serotonin in moral behavior (AMY -> HYP, abstract)
FAM.FT.SEP.LT Lateral Septal Nucleus inhibitory-gaba uncertain Cingulate Gyrus (SEP -> HT, abstract)
FEC FEC.HT.TG.RMTG Rostromedial Tegmental Nucleus inhibitory-gaba uncertain (unknown reference)
LAC LAC.FD.HT.DM Dorsomedial Hypothalamic Nucleus excitatory-glu uncertain Eating and sleeping to survive (DMH -> VLPO)
LAC.FD.HT.SCN Suprachiasmatic Nucleus excitatory-glu uncertain (unknown reference)
LAC.FD.HT.TBM Tuberomammillary Nucleus modulatory-hist modulator Simplified NREM sleep-promoting pathway (TMN -> VLPO)
LAC.FD.HT.VM Ventromedial Hypothalamic Nucleus excitatory-glu uncertain (unknown reference)
LMC LMC.HT.LC Locus Coeruleus modulatory-ne uncertain Simplified NREM sleep-promoting pathway (LC -> VLPO)
NSA NSA.NC.PH.PRP Prepyriform Cortex excitatory-glu uncertain (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
FAM FAM.FD.LHB.LT Lateral Habenula Lateral Part excitatory-glu uncertain Habenula Connections (LPO -> LHb, abstract)
FAM.FD.LHB.MED Lateral Habenula Medial Part excitatory-glu uncertain Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM)
LAC LAC.FD.HT.SUM Supramammillary Nucleus excitatory-glu uncertain (unknown reference)
LMC LMC.HT.TG.LDT Laterodorsal Tegmental Nucleus excitatory-glu uncertain Simplified NREM sleep-promoting pathway (VLPO -> LDTg)

Thirdparty Circuits


LC=Locus Coeruleus,LMC.HT.LC
LDTg=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT
TMN=Tuberomammillary Nucleus,LAC.FD.HT.TBM
VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO

DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN
GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT
LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED
LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
LS=Lateral Septal Nucleus,FAM.FT.SEP.LT
MHb=Medial Habenula,FAM.FD.MHB
MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
MS=Medial Septal Nucleus,FAM.FT.SEP.MED
PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei)
RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA

CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DR=Dorsal Raphe Nucleus,LMC.MM.RP.DRN
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
IP=Interpeduncular Nucleus,FEC.HT.TG.IPD
LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
LHb=Lateral Habenula,FAM.FD.LHB (see Habenula)
LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
MHb=Medial Habenula,FAM.FD.MHB
MR=Superior Central Raphe Nucleus,LMC.MM.RP.SUC
S=Septal Nuclei,FAM.FT.SEP
SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
VTA=Ventral Tegmental Area,LMC.MM.VTA

ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR
DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM
LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
MPO=Median Preoptic Nucleus,LAC.FD.HT.MPO
PVH=Paraventricular Nucleus,LAC.FD.HT.PV
SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN
VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM