Difference between revisions of "BrainAreaLMC"

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(generated)
 
(generated)
  
|| '''ID''' || '''Name''' || '''Regions''' ||
+
{| class=wikitable width=80%
|| 5HT || Serotonin - Feelings of Well-Being and Happiness || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]], [[BrainRegionLMC_HM_RP_OB|LMC.HM.RP.OB]], [[BrainRegionLMC_HM_RP_PL|LMC.HM.RP.PL]], [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]], [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]], [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] ||
+
| '''ID''' || '''Name''' || '''Regions'''  
|| ACH || Acetylcholine - PNS Actions and CNS plasticity, arousal and reward || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]], [[BrainRegionLMC_HP_TG_DTG|LMC.HP.TG.DTG]], [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]], [[BrainRegionLMC_HP_TG_VTG|LMC.HP.TG.VTG]] ||
+
|-
|| DA || Dopamine - Reward-Motivated Behavior, Cognitive Alertness || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] ||
+
| 5HT || Serotonin - Feelings of Well-Being and Happiness || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]], [[BrainRegionLMC_HM_RP_OB|LMC.HM.RP.OB]], [[BrainRegionLMC_HM_RP_PL|LMC.HM.RP.PL]], [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]], [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]], [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]]  
|| ENK || Enkephalin -  Regulating Nociception in Body || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] ||
+
|-
|| NE || Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] ||
+
| ACH || Acetylcholine - PNS Actions and CNS plasticity, arousal and reward || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]], [[BrainRegionLMC_HP_TG_DTG|LMC.HP.TG.DTG]], [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]], [[BrainRegionLMC_HP_TG_VTG|LMC.HP.TG.VTG]]  
 +
|-
 +
| DA || Dopamine - Reward-Motivated Behavior, Cognitive Alertness || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]]  
 +
|-
 +
| ENK || Enkephalin -  Regulating Nociception in Body || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]]  
 +
|-
 +
| NE || Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response || [[BrainRegionLMC_HP_LC|LMC.HP.LC]]  
 +
|}
  
 
== Serotonin - Feelings of Well-Being and Happiness ==
 
== Serotonin - Feelings of Well-Being and Happiness ==
Line 21: Line 28:
 
<img src="http://ahuman.googlecode.com/svn/images/dot/aHuman/LMC_5HT.dot.png" alt="unavailable">
 
<img src="http://ahuman.googlecode.com/svn/images/dot/aHuman/LMC_5HT.dot.png" alt="unavailable">
  
|| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments''' ||
+
{| class=wikitable width=80%
|| [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || Raphe Magnus Nucleus || nucleus || LUS || Inhubit head and spinal pain || B3, contacts with enkephalenic neurons in<BR>substantia gelatinosa ||
+
| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments'''  
|| [[BrainRegionLMC_HM_RP_OB|LMC.HM.RP.OB]] || Raphe Obscurus Nucleus || nucleus || LUS || Regulate cardiovascular function via sympathetic spinal column || B2 ||
+
|-
|| [[BrainRegionLMC_HM_RP_PL|LMC.HM.RP.PL]] || Raphe Pallidus Nucleus || nucleus || LUS || Spinal pain control || B1 ||
+
| [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || Raphe Magnus Nucleus || nucleus || LUS || Inhubit head and spinal pain || B3, contacts with enkephalenic neurons in<BR>substantia gelatinosa  
|| [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || Pontine Raphe Nucleus || nucleus || LUS || Regulation of sleep cycle || Projects to CR, forebrain; inhibitory nucleus ||
+
|-
|| [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || Superior Central Raphe Nucleus || nucleus || LUS || Block or temporarily suspend mnemonic processes in the hippocampus;<BR>Hallucinations || Directs HC to disregard insignificant events;<BR>inhibitory nucleus; B6,B8; Insomnia; inhibitory<BR>nucleus ||
+
| [[BrainRegionLMC_HM_RP_OB|LMC.HM.RP.OB]] || Raphe Obscurus Nucleus || nucleus || LUS || Regulate cardiovascular function via sympathetic spinal column || B2  
|| [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || Dorsal Raphe Nucleus || nucleus || LUS || Regulation of sleep and mood || Major source of 5HT; inhibitory nucleus ||
+
|-
 +
| [[BrainRegionLMC_HM_RP_PL|LMC.HM.RP.PL]] || Raphe Pallidus Nucleus || nucleus || LUS || Spinal pain control || B1  
 +
|-
 +
| [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || Pontine Raphe Nucleus || nucleus || LUS || Regulation of sleep cycle || Projects to CR, forebrain; inhibitory nucleus  
 +
|-
 +
| [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || Superior Central Raphe Nucleus || nucleus || LUS || Block or temporarily suspend mnemonic processes in the hippocampus;<BR>Hallucinations || Directs HC to disregard insignificant events;<BR>inhibitory nucleus; B6,B8; Insomnia; inhibitory<BR>nucleus  
 +
|-
 +
| [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || Dorsal Raphe Nucleus || nucleus || LUS || Regulation of sleep and mood || Major source of 5HT; inhibitory nucleus  
 +
|}
  
*Internal Region Connections:*
+
'''Internal Region Connections:'''
 
* no connections
 
* no connections
  
*External Inbound Region Connections:*
+
'''External Inbound Region Connections:'''
  
|| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference''' ||
+
{| class=wikitable width=80%
|| <font color="red">Subcortical</font> || || || || || ||
+
| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''  
|| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [[http://www.scholarpedia.org/article/Habenula|Habenula Connections (LHb -> MR, abstract)]] ||
+
|-
||  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [[http://www.scholarpedia.org/article/Habenula|Habenula Connections (LHb -> DR, abstract)]] ||
+
| <font color="red">Subcortical</font> || || || || ||  
|| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || [[BrainRegionLAC_FD_HT_LTN|LAC.FD.HT.LTN]] || Lateral Hypothalamic Nucleus || nucleus-nucleus || (unknown reference) ||
+
|-
||  ||  || [[BrainRegionLAC_FD_HT_PV|LAC.FD.HT.PV]] || Paraventricular Nucleus || nucleus-nucleus || (unknown reference) ||
+
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [[http://www.scholarpedia.org/article/Habenula|Habenula Connections (LHb -> MR, abstract)]]  
||  || [[BrainRegionLMC_HM_RP_OB|LMC.HM.RP.OB]] || [[BrainRegionLAC_FD_HT_PO|LAC.FD.HT.PO]] || Preoptic Nucleus || nucleus-nucleus || (unknown reference) ||
+
|-
|| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || [[BrainRegionLLC_MM_SCNF|LLC.MM.SCNF]] || Subcuneiform Nucleus || nucleus-nucleus || (unknown reference) ||
+
|  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [[http://www.scholarpedia.org/article/Habenula|Habenula Connections (LHb -> DR, abstract)]]  
||  || [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || [[BrainRegionLLC_MM_SCNF|LLC.MM.SCNF]] || Subcuneiform Nucleus || nucleus-nucleus || (unknown reference) ||
+
|-
||  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || nucleus-nucleus-gaba || (unknown reference) ||
+
| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || [[BrainRegionLAC_FD_HT_LTN|LAC.FD.HT.LTN]] || Lateral Hypothalamic Nucleus || nucleus-nucleus || (unknown reference)  
|| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus-nucleus-ENK || (unknown reference) ||
+
|-
||  || [[BrainRegionLMC_HM_RP_PL|LMC.HM.RP.PL]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus-nucleus-ENK || (unknown reference) ||
+
|  ||  || [[BrainRegionLAC_FD_HT_PV|LAC.FD.HT.PV]] || Paraventricular Nucleus || nucleus-nucleus || (unknown reference)  
 +
|-
 +
|  || [[BrainRegionLMC_HM_RP_OB|LMC.HM.RP.OB]] || [[BrainRegionLAC_FD_HT_PO|LAC.FD.HT.PO]] || Preoptic Nucleus || nucleus-nucleus || (unknown reference)  
 +
|-
 +
| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || [[BrainRegionLLC_MM_SCNF|LLC.MM.SCNF]] || Subcuneiform Nucleus || nucleus-nucleus || (unknown reference)  
 +
|-
 +
|  || [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || [[BrainRegionLLC_MM_SCNF|LLC.MM.SCNF]] || Subcuneiform Nucleus || nucleus-nucleus || (unknown reference)  
 +
|-
 +
|  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || nucleus-nucleus-gaba || (unknown reference)  
 +
|-
 +
| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus-nucleus-ENK || (unknown reference)  
 +
|-
 +
|  || [[BrainRegionLMC_HM_RP_PL|LMC.HM.RP.PL]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus-nucleus-ENK || (unknown reference)  
 +
|}
  
*External Outbound Region Connections:*
+
'''External Outbound Region Connections:'''
  
|| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference''' ||
+
{| class=wikitable width=80%
|| <font color="red">Subcortical</font> || || || || || ||
+
| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''  
|| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionFAM_FD_LHB_LT|FAM.FD.LHB.LT]] || Lateral Habenula Lateral Part || nucleus-nucleus-5HT || (unknown reference) ||
+
|-
||  ||  || [[BrainRegionFAM_FT_SEP_LT|FAM.FT.SEP.LT]] || Lateral Septal Nucleus || nucleus-nucleus-5HT || (unknown reference) ||
+
| <font color="red">Subcortical</font> || || || || ||  
|| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionFEC_FD_STN_ICD|FEC.FD.STN.ICD]] || Subthalamic Nucleus Internal Caudal || nucleus-nucleus-5HT || (unknown reference) ||
+
|-
|| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionFMM_FD_MB_MMB|FMM.FD.MB.MMB]] || Medial Mammillary Nucleus || nucleus-nucleus-5HT || (unknown reference) ||
+
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionFAM_FD_LHB_LT|FAM.FD.LHB.LT]] || Lateral Habenula Lateral Part || nucleus-nucleus-5HT || (unknown reference)  
|| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionLAC_FD_HT_PN|LAC.FD.HT.PN]] || Posterior Hypothalamic Nucleus || nucleus-nucleus-5HT || (unknown reference) ||
+
|-
||  ||  || [[BrainRegionLAC_FD_HT_SUM|LAC.FD.HT.SUM]] || Supramammillary Nucleus || nucleus-nucleus-5HT || (unknown reference) ||
+
|  ||  || [[BrainRegionFAM_FT_SEP_LT|FAM.FT.SEP.LT]] || Lateral Septal Nucleus || nucleus-nucleus-5HT || (unknown reference)  
|| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_HM_RP_OB|LMC.HM.RP.OB]] || [[BrainRegionLLC_HP_CR_SC|LLC.HP.CR.SC]] || Spinocerebellum || nucleus-allocortex-5HT || (unknown reference) ||
+
|-
||  || [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || [[BrainRegionLLC_HP_CR_SC|LLC.HP.CR.SC]] || Spinocerebellum || nucleus-allocortex-5HT || (unknown reference) ||
+
| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionFEC_FD_STN_ICD|FEC.FD.STN.ICD]] || Subthalamic Nucleus Internal Caudal || nucleus-nucleus-5HT || (unknown reference)  
|| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || [[BrainRegionLPC_SC_PH_LSG|LPC.SC.PH.LSG]] || Lower Substantia Gelatinosa || nucleus-nucleus-5HT || (unknown reference) ||
+
|-
||  ||  || [[BrainRegionLPC_SC_PH_USG|LPC.SC.PH.USG]] || Upper Substantia Gelatinosa || nucleus-nucleus-5HT || (unknown reference) ||
+
| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionFMM_FD_MB_MMB|FMM.FD.MB.MMB]] || Medial Mammillary Nucleus || nucleus-nucleus-5HT || (unknown reference)  
||  || [[BrainRegionLMC_HM_RP_OB|LMC.HM.RP.OB]] || [[BrainRegionLPC_SC_IZ_IMM|LPC.SC.IZ.IMM]] || Intermediomedial Nucleus || nucleus-nucleus-5HT || (unknown reference) ||
+
|-
||  || [[BrainRegionLMC_HM_RP_PL|LMC.HM.RP.PL]] || [[BrainRegionLPC_SC_PH_LMG|LPC.SC.PH.LMG]] || Lower Marginal Nucleus || nucleus-nucleus-5HT || (unknown reference) ||
+
| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionLAC_FD_HT_PN|LAC.FD.HT.PN]] || Posterior Hypothalamic Nucleus || nucleus-nucleus-5HT || (unknown reference)  
||  ||  || [[BrainRegionLPC_SC_PH_UMG|LPC.SC.PH.UMG]] || Upper Marginal Nucleus || nucleus-nucleus-5HT || (unknown reference) ||
+
|-
||  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionLPC_FD_TH_PV|LPC.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || nucleus-nucleus-5HT || (unknown reference) ||
+
|  ||  || [[BrainRegionLAC_FD_HT_SUM|LAC.FD.HT.SUM]] || Supramammillary Nucleus || nucleus-nucleus-5HT || (unknown reference)  
 +
|-
 +
| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_HM_RP_OB|LMC.HM.RP.OB]] || [[BrainRegionLLC_HP_CR_SC|LLC.HP.CR.SC]] || Spinocerebellum || nucleus-allocortex-5HT || (unknown reference)  
 +
|-
 +
|  || [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || [[BrainRegionLLC_HP_CR_SC|LLC.HP.CR.SC]] || Spinocerebellum || nucleus-allocortex-5HT || (unknown reference)  
 +
|-
 +
| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || [[BrainRegionLPC_SC_PH_LSG|LPC.SC.PH.LSG]] || Lower Substantia Gelatinosa || nucleus-nucleus-5HT || (unknown reference)  
 +
|-
 +
|  ||  || [[BrainRegionLPC_SC_PH_USG|LPC.SC.PH.USG]] || Upper Substantia Gelatinosa || nucleus-nucleus-5HT || (unknown reference)  
 +
|-
 +
|  || [[BrainRegionLMC_HM_RP_OB|LMC.HM.RP.OB]] || [[BrainRegionLPC_SC_IZ_IMM|LPC.SC.IZ.IMM]] || Intermediomedial Nucleus || nucleus-nucleus-5HT || (unknown reference)  
 +
|-
 +
|  || [[BrainRegionLMC_HM_RP_PL|LMC.HM.RP.PL]] || [[BrainRegionLPC_SC_PH_LMG|LPC.SC.PH.LMG]] || Lower Marginal Nucleus || nucleus-nucleus-5HT || (unknown reference)  
 +
|-
 +
|  ||  || [[BrainRegionLPC_SC_PH_UMG|LPC.SC.PH.UMG]] || Upper Marginal Nucleus || nucleus-nucleus-5HT || (unknown reference)  
 +
|-
 +
|  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionLPC_FD_TH_PV|LPC.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || nucleus-nucleus-5HT || (unknown reference)  
 +
|}
  
 
== Acetylcholine - PNS Actions and CNS plasticity, arousal and reward ==
 
== Acetylcholine - PNS Actions and CNS plasticity, arousal and reward ==
Line 71: Line 116:
 
<img src="http://ahuman.googlecode.com/svn/images/dot/aHuman/LMC_ACH.dot.png" alt="unavailable">
 
<img src="http://ahuman.googlecode.com/svn/images/dot/aHuman/LMC_ACH.dot.png" alt="unavailable">
  
|| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments''' ||
+
{| class=wikitable width=80%
|| [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || Basal Nucleus of Meynert || nucleus || FAU || Control imagination vs perception || ACh source, attention; modulatory nucleus ||
+
| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments'''  
|| [[BrainRegionLMC_HP_TG_DTG|LMC.HP.TG.DTG]] || Dorsal Tegmental Nucleus || nucleus || LUS || accurate landmark navigation || vestibular sensory information to mammllary bodies<BR>for orientation ||
+
|-
|| [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || Laterodorsal Tegmental Nucleus || nucleus || LUS || Modulating sustained attention or in mediating alerting responses || sleep, waking, motor function, learning and reward ||
+
| [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || Basal Nucleus of Meynert || nucleus || FAU || Control imagination vs perception || ACh source, attention; modulatory nucleus  
|| [[BrainRegionLMC_HP_TG_VTG|LMC.HP.TG.VTG]] || Ventral Tegmental Nucleus || nucleus || LUS || moderates hippocampal-driven rhythmic firing frequency in medial mammillary || contribute to episodic memory and new learning in<BR>humans as well as spatial memory ||
+
|-
 +
| [[BrainRegionLMC_HP_TG_DTG|LMC.HP.TG.DTG]] || Dorsal Tegmental Nucleus || nucleus || LUS || accurate landmark navigation || vestibular sensory information to mammllary bodies<BR>for orientation  
 +
|-
 +
| [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || Laterodorsal Tegmental Nucleus || nucleus || LUS || Modulating sustained attention or in mediating alerting responses || sleep, waking, motor function, learning and reward  
 +
|-
 +
| [[BrainRegionLMC_HP_TG_VTG|LMC.HP.TG.VTG]] || Ventral Tegmental Nucleus || nucleus || LUS || moderates hippocampal-driven rhythmic firing frequency in medial mammillary || contribute to episodic memory and new learning in<BR>humans as well as spatial memory  
 +
|}
  
*Internal Region Connections:*
+
'''Internal Region Connections:'''
 
* no connections
 
* no connections
  
*External Inbound Region Connections:*
+
'''External Inbound Region Connections:'''
  
|| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference''' ||
+
{| class=wikitable width=80%
|| <font color="red">Cortical</font> || || || || || ||
+
| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''  
|| [[BrainAreaNSA|NSA]] || [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || [[BrainRegionNSA_FD_TH_SG|NSA.FD.TH.SG]] || Suprageniculate Nucleus of Thalamus || nucleus-nucleus || [[http://www.scholarpedia.org/article/Head_direction_cells|Head Direction Cell Circuit (SUPGEN -> DTN)]] ||
+
|-
|| <font color="red">Subcortical</font> || || || || || ||
+
| <font color="red">Cortical</font> || || || || ||  
|| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionFAM_FT_AM_AB|FAM.FT.AM.AB]] || Accessory Basal Amygdaloid Nucleus || nucleus-nucleus || (unknown reference) ||
+
|-
||  ||  || [[BrainRegionFAM_FT_AM_BP|FAM.FT.AM.BP]] || Parvicellular Basal Amygdaloid Nucleus || nucleus-nucleus || (unknown reference) ||
+
| [[BrainAreaNSA|NSA]] || [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || [[BrainRegionNSA_FD_TH_SG|NSA.FD.TH.SG]] || Suprageniculate Nucleus of Thalamus || nucleus-nucleus || [[http://www.scholarpedia.org/article/Head_direction_cells|Head Direction Cell Circuit (SUPGEN -> DTN)]]  
||  ||  || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || nucleus-nucleus || (unknown reference) ||
+
|-
||  ||  || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || nucleus-nucleus || (unknown reference) ||
+
| <font color="red">Subcortical</font> || || || || ||  
||  || [[BrainRegionLMC_HP_TG_DTG|LMC.HP.TG.DTG]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || (unknown reference) ||
+
|-
||  || [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || [[BrainRegionFAM_HP_PPN_RMTG|FAM.HP.PPN.RMTG]] || Rostromedial Tegmental Nucleus || nucleus-nucleus-gaba || (unknown reference) ||
+
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionFAM_FT_AM_AB|FAM.FT.AM.AB]] || Accessory Basal Amygdaloid Nucleus || nucleus-nucleus || (unknown reference)  
||  || [[BrainRegionLMC_HP_TG_VTG|LMC.HP.TG.VTG]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || (unknown reference) ||
+
|-
|| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionFEC_FD_STN_CD|FEC.FD.STN.CD]] || Subthalamic Nucleus Caudal || nucleus-nucleus || (unknown reference) ||
+
|  ||  || [[BrainRegionFAM_FT_AM_BP|FAM.FT.AM.BP]] || Parvicellular Basal Amygdaloid Nucleus || nucleus-nucleus || (unknown reference)  
||  ||  || [[BrainRegionFEC_FT_ACC_SH|FEC.FT.ACC.SH]] || Nucleus Accumbens Shell || nucleus-nucleus-gaba || [[http://www.expertsmind.com/topic/emotion/affective-basal-ganglia-circuit-93570.aspx|Affective basal ganglia circuit (NACC -> nBM, abstract)]] ||
+
|-
|| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || [[BrainRegionFMM_FD_MB_LMB|FMM.FD.MB.LMB]] || Lateral Mammillary Nucleus || nucleus-nucleus || [[http://www.scholarpedia.org/article/Head_direction_cells|Head Direction Cell Circuit (LMB -> DTN)]] ||
+
|  ||  || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || nucleus-nucleus || (unknown reference)  
|| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HP_TG_DTG|LMC.HP.TG.DTG]] || [[BrainRegionLRC_HM_NPH|LRC.HM.NPH]] || Prepositus Nucleus || nucleus-nucleus || (unknown reference) ||
+
|-
 +
|  ||  || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || nucleus-nucleus || (unknown reference)  
 +
|-
 +
|  || [[BrainRegionLMC_HP_TG_DTG|LMC.HP.TG.DTG]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || (unknown reference)  
 +
|-
 +
|  || [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || [[BrainRegionFAM_HP_PPN_RMTG|FAM.HP.PPN.RMTG]] || Rostromedial Tegmental Nucleus || nucleus-nucleus-gaba || (unknown reference)  
 +
|-
 +
|  || [[BrainRegionLMC_HP_TG_VTG|LMC.HP.TG.VTG]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || (unknown reference)  
 +
|-
 +
| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionFEC_FD_STN_CD|FEC.FD.STN.CD]] || Subthalamic Nucleus Caudal || nucleus-nucleus || (unknown reference)  
 +
|-
 +
|  ||  || [[BrainRegionFEC_FT_ACC_SH|FEC.FT.ACC.SH]] || Nucleus Accumbens Shell || nucleus-nucleus-gaba || [[http://www.expertsmind.com/topic/emotion/affective-basal-ganglia-circuit-93570.aspx|Affective basal ganglia circuit (NACC -> nBM, abstract)]]  
 +
|-
 +
| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || [[BrainRegionFMM_FD_MB_LMB|FMM.FD.MB.LMB]] || Lateral Mammillary Nucleus || nucleus-nucleus || [[http://www.scholarpedia.org/article/Head_direction_cells|Head Direction Cell Circuit (LMB -> DTN)]]  
 +
|-
 +
| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HP_TG_DTG|LMC.HP.TG.DTG]] || [[BrainRegionLRC_HM_NPH|LRC.HM.NPH]] || Prepositus Nucleus || nucleus-nucleus || (unknown reference)  
 +
|}
  
*External Outbound Region Connections:*
+
'''External Outbound Region Connections:'''
  
|| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference''' ||
+
{| class=wikitable width=80%
|| <font color="red">Cortical</font> || || || || || ||
+
| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''  
|| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionNDM_NC_AL_FPC|NDM.NC.AL.FPC]] || Lateral Frontopolar Cortex || nucleus-neocortex-ACh || [[http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders|Physiology and pathophysiology of lower urinary tract (NBM -> MPFC, abstract)]] ||
+
|-
|| [[BrainAreaNSA|NSA]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionNSA_NC_OCC_V1|NSA.NC.OCC.V1]] || Primary Visual Cortex || nucleus-neocortex-ACh || (unknown reference) ||
+
| <font color="red">Cortical</font> || || || || ||  
|| <font color="red">Subcortical</font> || || || || || ||
+
|-
|| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionFAM_FT_AM_BM|FAM.FT.AM.BM]] || Magnocellular Basal Amygdaloid Nucleus || nucleus-nucleus-ACh || (unknown reference) ||
+
| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionNDM_NC_AL_FPC|NDM.NC.AL.FPC]] || Lateral Frontopolar Cortex || nucleus-neocortex-ACh || [[http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders|Physiology and pathophysiology of lower urinary tract (NBM -> MPFC, abstract)]]  
||  || [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || [[BrainRegionFAM_HP_PPN_IPD|FAM.HP.PPN.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || [[http://www.scholarpedia.org/article/Head_direction_cells|Head Direction Cell Circuit (DTN -> IPD)]] ||
+
|-
|| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_HP_TG_DTG|LMC.HP.TG.DTG]] || [[BrainRegionFMM_FD_MB_LMB|FMM.FD.MB.LMB]] || Lateral Mammillary Nucleus || nucleus-nucleus-ACh || (unknown reference) ||
+
| [[BrainAreaNSA|NSA]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionNSA_NC_OCC_V1|NSA.NC.OCC.V1]] || Primary Visual Cortex || nucleus-neocortex-ACh || (unknown reference)  
||  || [[BrainRegionLMC_HP_TG_VTG|LMC.HP.TG.VTG]] || [[BrainRegionFMM_FD_MB_MMB|FMM.FD.MB.MMB]] || Medial Mammillary Nucleus || nucleus-nucleus || (unknown reference) ||
+
|-
|| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || [[BrainRegionLAC_HM_SAL_ISL|LAC.HM.SAL.ISL]] || Inferior Salivatory Nucleus || nucleus-nucleus-ACh || (unknown reference) ||
+
| <font color="red">Subcortical</font> || || || || ||  
||  ||  || [[BrainRegionLAC_HM_SAL_SSL|LAC.HM.SAL.SSL]] || Superior Salivatory Nucleus || nucleus-nucleus-ACh || (unknown reference) ||
+
|-
|| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HP_TG_VTG|LMC.HP.TG.VTG]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || Ventral Tegmental Area || nucleus-nucleus || (unknown reference) ||
+
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]] || [[BrainRegionFAM_FT_AM_BM|FAM.FT.AM.BM]] || Magnocellular Basal Amygdaloid Nucleus || nucleus-nucleus-ACh || (unknown reference)  
|| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || [[BrainRegionLRC_HM_NPH|LRC.HM.NPH]] || Prepositus Nucleus || nucleus-nucleus-ACh || [[http://www.scholarpedia.org/article/Head_direction_cells|Head Direction Cell Circuit (DTN -> NPRP)]] ||
+
|-
 +
|  || [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || [[BrainRegionFAM_HP_PPN_IPD|FAM.HP.PPN.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || [[http://www.scholarpedia.org/article/Head_direction_cells|Head Direction Cell Circuit (DTN -> IPD)]]  
 +
|-
 +
| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_HP_TG_DTG|LMC.HP.TG.DTG]] || [[BrainRegionFMM_FD_MB_LMB|FMM.FD.MB.LMB]] || Lateral Mammillary Nucleus || nucleus-nucleus-ACh || (unknown reference)  
 +
|-
 +
|  || [[BrainRegionLMC_HP_TG_VTG|LMC.HP.TG.VTG]] || [[BrainRegionFMM_FD_MB_MMB|FMM.FD.MB.MMB]] || Medial Mammillary Nucleus || nucleus-nucleus || (unknown reference)  
 +
|-
 +
| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || [[BrainRegionLAC_HM_SAL_ISL|LAC.HM.SAL.ISL]] || Inferior Salivatory Nucleus || nucleus-nucleus-ACh || (unknown reference)  
 +
|-
 +
|  ||  || [[BrainRegionLAC_HM_SAL_SSL|LAC.HM.SAL.SSL]] || Superior Salivatory Nucleus || nucleus-nucleus-ACh || (unknown reference)  
 +
|-
 +
| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HP_TG_VTG|LMC.HP.TG.VTG]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || Ventral Tegmental Area || nucleus-nucleus || (unknown reference)  
 +
|-
 +
| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HP_TG_LDT|LMC.HP.TG.LDT]] || [[BrainRegionLRC_HM_NPH|LRC.HM.NPH]] || Prepositus Nucleus || nucleus-nucleus-ACh || [[http://www.scholarpedia.org/article/Head_direction_cells|Head Direction Cell Circuit (DTN -> NPRP)]]  
 +
|}
  
 
== Dopamine - Reward-Motivated Behavior, Cognitive Alertness ==
 
== Dopamine - Reward-Motivated Behavior, Cognitive Alertness ==
Line 119: Line 200:
 
<img src="http://ahuman.googlecode.com/svn/images/dot/aHuman/LMC_DA.dot.png" alt="unavailable">
 
<img src="http://ahuman.googlecode.com/svn/images/dot/aHuman/LMC_DA.dot.png" alt="unavailable">
  
|| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments''' ||
+
{| class=wikitable width=80%
|| [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || Ventral Tegmental Area || nucleus || LUS || Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues ||  ||
+
| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments'''  
 +
|-
 +
| [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || Ventral Tegmental Area || nucleus || LUS || Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues ||   
 +
|}
  
*Internal Region Connections:*
+
'''Internal Region Connections:'''
 
* no connections
 
* no connections
  
*External Inbound Region Connections:*
+
'''External Inbound Region Connections:'''
  
|| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference''' ||
+
{| class=wikitable width=80%
|| <font color="red">Subcortical</font> || || || || || ||
+
| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''  
|| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || nucleus-nucleus || (unknown reference) ||
+
|-
|| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFEC_FT_ACC_CORE|FEC.FT.ACC.CORE]] || Nucleus Accumbens Core || nucleus-nucleus-gaba || [[http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity|Reward circuit of human brain (NACC -> VTA, abstract)]] ||
+
| <font color="red">Subcortical</font> || || || || ||  
|| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionLMC_HP_TG_VTG|LMC.HP.TG.VTG]] || Ventral Tegmental Nucleus || nucleus-nucleus || (unknown reference) ||
+
|-
 +
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || nucleus-nucleus || (unknown reference)  
 +
|-
 +
| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFEC_FT_ACC_CORE|FEC.FT.ACC.CORE]] || Nucleus Accumbens Core || nucleus-nucleus-gaba || [[http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity|Reward circuit of human brain (NACC -> VTA, abstract)]]  
 +
|-
 +
| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionLMC_HP_TG_VTG|LMC.HP.TG.VTG]] || Ventral Tegmental Nucleus || nucleus-nucleus || (unknown reference)  
 +
|}
  
*External Outbound Region Connections:*
+
'''External Outbound Region Connections:'''
  
|| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference''' ||
+
{| class=wikitable width=80%
|| <font color="red">Cortical</font> || || || || || ||
+
| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''  
|| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionNDM_NC_AL_DACG|NDM.NC.AL.DACG]] || Dorsal Anterior Cingulate Area || nucleus-neocortex-DA || (unknown reference) ||
+
|-
||  ||  || [[BrainRegionNDM_NC_AL_FPC|NDM.NC.AL.FPC]] || Lateral Frontopolar Cortex || nucleus-neocortex-DA || [[http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity|Reward circuit of human brain (VTA -> PFC, abstract)]] ||
+
| <font color="red">Cortical</font> || || || || ||  
|| <font color="red">Subcortical</font> || || || || || ||
+
|-
|| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFAM_FT_AM_CEC|FAM.FT.AM.CEC]] || Central Amygdaloid Nucleus, capsular subdivision || nucleus-nucleus-DA || [[http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity|Reward circuit of human brain (VTA -> AM, abstract)]] ||
+
| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionNDM_NC_AL_DACG|NDM.NC.AL.DACG]] || Dorsal Anterior Cingulate Area || nucleus-neocortex-DA || (unknown reference)  
|| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFEC_FT_ACC_SH|FEC.FT.ACC.SH]] || Nucleus Accumbens Shell || nucleus-nucleus-DA || [[http://www.impulsecontroldisorders.org/html/cravings.html|Craving (VTA -> NACC, abstract)]] ||
+
|-
|| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFMM_FD_MB_MMB|FMM.FD.MB.MMB]] || Medial Mammillary Nucleus || nucleus-nucleus-DA || [[http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html|Mammillary bodies: two memory systems in one (VTN -> MMB)]] ||
+
|  ||  || [[BrainRegionNDM_NC_AL_FPC|NDM.NC.AL.FPC]] || Lateral Frontopolar Cortex || nucleus-neocortex-DA || [[http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity|Reward circuit of human brain (VTA -> PFC, abstract)]]  
||  ||  || [[BrainRegionFMM_FT_HC_CA1D|FMM.FT.HC.CA1D]] || Distal CA1 of Hippocampus || nucleus-allocortex-DA || [[http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity|Reward circuit of human brain (VTA -> HC, abstract)]] ||
+
|-
||  ||  || [[BrainRegionFMM_NC_PH_LEC|FMM.NC.PH.LEC]] || Lateral Entorhinal Cortex || nucleus-neocortex-DA || [[http://www.impulsecontroldisorders.org/html/cravings.html|Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)]] ||
+
| <font color="red">Subcortical</font> || || || || ||  
|| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionLAC_FD_HT_PO|LAC.FD.HT.PO]] || Preoptic Nucleus || nucleus-nucleus-DA || [[http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders|Physiology and pathophysiology of lower urinary tract (VTA -> MPOA)]] ||
+
|-
||  ||  || [[BrainRegionLAC_FD_HT_PRM|LAC.FD.HT.PRM]] || Premammillary Nucleus || nucleus-nucleus-DA || (unknown reference) ||
+
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFAM_FT_AM_CEC|FAM.FT.AM.CEC]] || Central Amygdaloid Nucleus, capsular subdivision || nucleus-nucleus-DA || [[http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity|Reward circuit of human brain (VTA -> AM, abstract)]]  
||  ||  || [[BrainRegionLAC_FD_HT_PV|LAC.FD.HT.PV]] || Paraventricular Nucleus || nucleus-nucleus-DA || [[http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders|Physiology and pathophysiology of lower urinary tract (VTA -> PVN)]] ||
+
|-
 +
| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFEC_FT_ACC_SH|FEC.FT.ACC.SH]] || Nucleus Accumbens Shell || nucleus-nucleus-DA || [[http://www.impulsecontroldisorders.org/html/cravings.html|Craving (VTA -> NACC, abstract)]]  
 +
|-
 +
| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionFMM_FD_MB_MMB|FMM.FD.MB.MMB]] || Medial Mammillary Nucleus || nucleus-nucleus-DA || [[http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html|Mammillary bodies: two memory systems in one (VTN -> MMB)]]  
 +
|-
 +
|  ||  || [[BrainRegionFMM_FT_HC_CA1D|FMM.FT.HC.CA1D]] || Distal CA1 of Hippocampus || nucleus-allocortex-DA || [[http://neurowiki2012.wikispaces.com/Presynaptic+Mechanisms+of+Synaptic+Plasticity|Reward circuit of human brain (VTA -> HC, abstract)]]  
 +
|-
 +
|  ||  || [[BrainRegionFMM_NC_PH_LEC|FMM.NC.PH.LEC]] || Lateral Entorhinal Cortex || nucleus-neocortex-DA || [[http://www.impulsecontroldisorders.org/html/cravings.html|Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)]]  
 +
|-
 +
| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_VTA|LMC.MM.VTA]] || [[BrainRegionLAC_FD_HT_PO|LAC.FD.HT.PO]] || Preoptic Nucleus || nucleus-nucleus-DA || [[http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders|Physiology and pathophysiology of lower urinary tract (VTA -> MPOA)]]  
 +
|-
 +
|  ||  || [[BrainRegionLAC_FD_HT_PRM|LAC.FD.HT.PRM]] || Premammillary Nucleus || nucleus-nucleus-DA || (unknown reference)  
 +
|-
 +
|  ||  || [[BrainRegionLAC_FD_HT_PV|LAC.FD.HT.PV]] || Paraventricular Nucleus || nucleus-nucleus-DA || [[http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders|Physiology and pathophysiology of lower urinary tract (VTA -> PVN)]]  
 +
|}
  
 
== Enkephalin -  Regulating Nociception in Body ==
 
== Enkephalin -  Regulating Nociception in Body ==
Line 154: Line 258:
 
<img src="http://ahuman.googlecode.com/svn/images/dot/aHuman/LMC_ENK.dot.png" alt="unavailable">
 
<img src="http://ahuman.googlecode.com/svn/images/dot/aHuman/LMC_ENK.dot.png" alt="unavailable">
  
|| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments''' ||
+
{| class=wikitable width=80%
|| [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus || LUS || Descending modulation of pain and in defensive behaviour || if there is a lesion in the PAG, then consciousness<BR>is lost; electrical stimulation of the PAG results<BR>in immediate and profound analgesia; modulatory<BR>nucleus ||
+
| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments'''  
 +
|-
 +
| [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus || LUS || Descending modulation of pain and in defensive behaviour || if there is a lesion in the PAG, then consciousness<BR>is lost; electrical stimulation of the PAG results<BR>in immediate and profound analgesia; modulatory<BR>nucleus  
 +
|}
  
*Internal Region Connections:*
+
'''Internal Region Connections:'''
 
* no connections
 
* no connections
  
*External Inbound Region Connections:*
+
'''External Inbound Region Connections:'''
  
|| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference''' ||
+
{| class=wikitable width=80%
|| <font color="red">Cortical</font> || || || || || ||
+
| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''  
|| [[BrainAreaNCP|NCP]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionNCP_NC_AL_SGCG|NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || neocortex-nucleus || (unknown reference) ||
+
|-
|| <font color="red">Subcortical</font> || || || || || ||
+
| <font color="red">Cortical</font> || || || || ||  
|| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || nucleus-nucleus || [[http://neuropolitics.org/defaultmay10.asp|Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)]] ||
+
|-
|| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLAC_FD_HT_VM|LAC.FD.HT.VM]] || Ventromedial Hypothalamic Nucleus || nucleus-nucleus || (unknown reference) ||
+
| [[BrainAreaNCP|NCP]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionNCP_NC_AL_SGCG|NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || neocortex-nucleus || (unknown reference)  
 +
|-
 +
| <font color="red">Subcortical</font> || || || || ||  
 +
|-
 +
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || nucleus-nucleus || [[http://neuropolitics.org/defaultmay10.asp|Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)]]  
 +
|-
 +
| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLAC_FD_HT_VM|LAC.FD.HT.VM]] || Ventromedial Hypothalamic Nucleus || nucleus-nucleus || (unknown reference)  
 +
|}
  
*External Outbound Region Connections:*
+
'''External Outbound Region Connections:'''
  
|| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference''' ||
+
{| class=wikitable width=80%
|| <font color="red">Subcortical</font> || || || || || ||
+
| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''  
|| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLAC_HP_BR|LAC.HP.BR]] || Barrington's Nucleus || nucleus-nucleus-ENK || [[http://jp.physoc.org/content/557/1/287/F9.expansion.html|Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)]] ||
+
|-
|| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || nucleus-nucleus-ENK || (unknown reference) ||
+
| <font color="red">Subcortical</font> || || || || ||  
|| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || Raphe Magnus Nucleus || nucleus-nucleus-ENK || (unknown reference) ||
+
|-
||  ||  || [[BrainRegionLMC_HM_RP_PL|LMC.HM.RP.PL]] || Raphe Pallidus Nucleus || nucleus-nucleus-ENK || (unknown reference) ||
+
| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLAC_HP_BR|LAC.HP.BR]] || Barrington's Nucleus || nucleus-nucleus-ENK || [[http://jp.physoc.org/content/557/1/287/F9.expansion.html|Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)]]  
|| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLPC_FD_TH_PV|LPC.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || nucleus-nucleus-ENK || (unknown reference) ||
+
|-
||  ||  || [[BrainRegionLPC_HM_AMB|LPC.HM.AMB]] || Ambiguus Nucleus || nucleus-nucleus-ENK || (unknown reference) ||
+
| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || nucleus-nucleus-ENK || (unknown reference)  
|| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLRC_HM_RA|LRC.HM.RA]] || Retroambigualis Nucleus || nucleus-nucleus-ENK || (unknown reference) ||
+
|-
||  ||  || [[BrainRegionLRC_HP_PN_SC|LRC.HP.PN.SC]] || Nucleus Subceruleus || nucleus-nucleus-ENK || (unknown reference) ||
+
| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || Raphe Magnus Nucleus || nucleus-nucleus-ENK || (unknown reference)  
 +
|-
 +
|  ||  || [[BrainRegionLMC_HM_RP_PL|LMC.HM.RP.PL]] || Raphe Pallidus Nucleus || nucleus-nucleus-ENK || (unknown reference)  
 +
|-
 +
| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLPC_FD_TH_PV|LPC.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || nucleus-nucleus-ENK || (unknown reference)  
 +
|-
 +
|  ||  || [[BrainRegionLPC_HM_AMB|LPC.HM.AMB]] || Ambiguus Nucleus || nucleus-nucleus-ENK || (unknown reference)  
 +
|-
 +
| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLRC_HM_RA|LRC.HM.RA]] || Retroambigualis Nucleus || nucleus-nucleus-ENK || (unknown reference)  
 +
|-
 +
|  ||  || [[BrainRegionLRC_HP_PN_SC|LRC.HP.PN.SC]] || Nucleus Subceruleus || nucleus-nucleus-ENK || (unknown reference)  
 +
|}
  
 
== Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response ==
 
== Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response ==
Line 187: Line 312:
 
<img src="http://ahuman.googlecode.com/svn/images/dot/aHuman/LMC_NE.dot.png" alt="unavailable">
 
<img src="http://ahuman.googlecode.com/svn/images/dot/aHuman/LMC_NE.dot.png" alt="unavailable">
  
|| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments''' ||
+
{| class=wikitable width=80%
|| [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || Locus Coeruleus || nucleus || LUS || Regulate the intensity of responses to salient stimuli || NE Source, enhance signal-to-noise ratio,<BR>suppressing irrelevant stimuli (lateral<BR>inhibition); inhibitory nucleus ||
+
| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments'''  
 +
|-
 +
| [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || Locus Coeruleus || nucleus || LUS || Regulate the intensity of responses to salient stimuli || NE Source, enhance signal-to-noise ratio,<BR>suppressing irrelevant stimuli (lateral<BR>inhibition); inhibitory nucleus  
 +
|}
  
*Internal Region Connections:*
+
'''Internal Region Connections:'''
 
* no connections
 
* no connections
  
*External Inbound Region Connections:*
+
'''External Inbound Region Connections:'''
  
|| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference''' ||
+
{| class=wikitable width=80%
|| <font color="red">Cortical</font> || || || || || ||
+
| '''Source Area''' || '''Local Region''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''  
|| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionNDM_NC_AL_VACG|NDM.NC.AL.VACG]] || Ventral Anterior Cingulate Area || neocortex-nucleus || [[http://www.frontiersin.org/neuroanatomy/10.3389/fnana.2011.00034/full|Vocal Control (Premotor24 -> RF, abstract)]] ||
+
|-
|| <font color="red">Subcortical</font> || || || || || ||
+
| <font color="red">Cortical</font> || || || || ||  
|| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || nucleus-nucleus || (unknown reference) ||
+
|-
|| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionLAC_FD_HT_DM|LAC.FD.HT.DM]] || Dorsomedial Hypothalamic Nucleus || nucleus-nucleus || (unknown reference) ||
+
| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionNDM_NC_AL_VACG|NDM.NC.AL.VACG]] || Ventral Anterior Cingulate Area || neocortex-nucleus || [[http://www.frontiersin.org/neuroanatomy/10.3389/fnana.2011.00034/full|Vocal Control (Premotor24 -> RF, abstract)]]  
||  ||  || [[BrainRegionLAC_FD_HT_TBM|LAC.FD.HT.TBM]] || Tuberomammillary Nucleus || nucleus-nucleus || (unknown reference) ||
+
|-
|| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionLRC_HM_RF_MED|LRC.HM.RF.MED]] || Central Medullary Reticular Nucleus || nucleus-nucleus || (unknown reference) ||
+
| <font color="red">Subcortical</font> || || || || ||  
 +
|-
 +
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || nucleus-nucleus || (unknown reference)  
 +
|-
 +
| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionLAC_FD_HT_DM|LAC.FD.HT.DM]] || Dorsomedial Hypothalamic Nucleus || nucleus-nucleus || (unknown reference)  
 +
|-
 +
|  ||  || [[BrainRegionLAC_FD_HT_TBM|LAC.FD.HT.TBM]] || Tuberomammillary Nucleus || nucleus-nucleus || (unknown reference)  
 +
|-
 +
| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionLRC_HM_RF_MED|LRC.HM.RF.MED]] || Central Medullary Reticular Nucleus || nucleus-nucleus || (unknown reference)  
 +
|}
  
*External Outbound Region Connections:*
+
'''External Outbound Region Connections:'''
  
|| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference''' ||
+
{| class=wikitable width=80%
|| <font color="red">Subcortical</font> || || || || || ||
+
| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''  
|| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionFAM_FD_MHB|FAM.FD.MHB]] || Medial Habenula || nucleus-nucleus-NE || (unknown reference) ||
+
|-
||  ||  || [[BrainRegionFAM_FT_SEP_DBB|FAM.FT.SEP.DBB]] || Diagonal Band of Broca || nucleus-nucleus-NE || (unknown reference) ||
+
| <font color="red">Subcortical</font> || || || || ||  
|| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionFEC_FT_SNC_MED|FEC.FT.SNC.MED]] || Substantia Nigra Pars Compacta Medial || nucleus-nucleus-NE || (unknown reference) ||
+
|-
|| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionLAC_SC_IZ_IML|LAC.SC.IZ.IML]] || Intermediolateral Nucleus || nucleus-nucleus-NE || [[http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders|Physiology and pathophysiology of lower urinary tract (LC -> IML)]] ||
+
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionFAM_FD_MHB|FAM.FD.MHB]] || Medial Habenula || nucleus-nucleus-NE || (unknown reference)  
 +
|-
 +
|  ||  || [[BrainRegionFAM_FT_SEP_DBB|FAM.FT.SEP.DBB]] || Diagonal Band of Broca || nucleus-nucleus-NE || (unknown reference)  
 +
|-
 +
| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionFEC_FT_SNC_MED|FEC.FT.SNC.MED]] || Substantia Nigra Pars Compacta Medial || nucleus-nucleus-NE || (unknown reference)  
 +
|-
 +
| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_HP_LC|LMC.HP.LC]] || [[BrainRegionLAC_SC_IZ_IML|LAC.SC.IZ.IML]] || Intermediolateral Nucleus || nucleus-nucleus-NE || [[http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders|Physiology and pathophysiology of lower urinary tract (LC -> IML)]]  
 +
|}
  
 
= Thirdparty Circuits =
 
= Thirdparty Circuits =

Revision as of 01:14, 17 June 2015

Modulatory Contol Area

Home -> BiologicalLifeResearch -> BrainAreaLMC


Local Circuits

(generated)

ID Name Regions
5HT Serotonin - Feelings of Well-Being and Happiness LMC.HM.RP.MG, LMC.HM.RP.OB, LMC.HM.RP.PL, LMC.HP.RP.PRN, LMC.MM.RF.SUC, LMC.MM.RP.DRN
ACH Acetylcholine - PNS Actions and CNS plasticity, arousal and reward LMC.FT.NBM, LMC.HP.TG.DTG, LMC.HP.TG.LDT, LMC.HP.TG.VTG
DA Dopamine - Reward-Motivated Behavior, Cognitive Alertness LMC.MM.VTA
ENK Enkephalin - Regulating Nociception in Body LMC.MM.PAG
NE Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response LMC.HP.LC

Serotonin - Feelings of Well-Being and Happiness

unavailable

Component ID Component Name Type Service Function Comments
LMC.HM.RP.MG Raphe Magnus Nucleus nucleus LUS Inhubit head and spinal pain B3, contacts with enkephalenic neurons in
substantia gelatinosa
LMC.HM.RP.OB Raphe Obscurus Nucleus nucleus LUS Regulate cardiovascular function via sympathetic spinal column B2
LMC.HM.RP.PL Raphe Pallidus Nucleus nucleus LUS Spinal pain control B1
LMC.HP.RP.PRN Pontine Raphe Nucleus nucleus LUS Regulation of sleep cycle Projects to CR, forebrain; inhibitory nucleus
LMC.MM.RF.SUC Superior Central Raphe Nucleus nucleus LUS Block or temporarily suspend mnemonic processes in the hippocampus;
Hallucinations
Directs HC to disregard insignificant events;
inhibitory nucleus; B6,B8; Insomnia; inhibitory
nucleus
LMC.MM.RP.DRN Dorsal Raphe Nucleus nucleus LUS Regulation of sleep and mood Major source of 5HT; inhibitory nucleus

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Subcortical
FAM LMC.MM.RF.SUC FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus [Connections (LHb -> MR, abstract)]
LMC.MM.RP.DRN FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus [Connections (LHb -> DR, abstract)]
LAC LMC.HM.RP.MG LAC.FD.HT.LTN Lateral Hypothalamic Nucleus nucleus-nucleus (unknown reference)
LAC.FD.HT.PV Paraventricular Nucleus nucleus-nucleus (unknown reference)
LMC.HM.RP.OB LAC.FD.HT.PO Preoptic Nucleus nucleus-nucleus (unknown reference)
LLC LMC.HM.RP.MG LLC.MM.SCNF Subcuneiform Nucleus nucleus-nucleus (unknown reference)
LMC.HP.RP.PRN LLC.MM.SCNF Subcuneiform Nucleus nucleus-nucleus (unknown reference)
LMC.MM.RP.DRN LLC.FD.TH.SF Subfascicular Nucleus of Thalamus nucleus-nucleus-gaba (unknown reference)
LMC LMC.HM.RP.MG LMC.MM.PAG Periaqueductal Gray Matter nucleus-nucleus-ENK (unknown reference)
LMC.HM.RP.PL LMC.MM.PAG Periaqueductal Gray Matter nucleus-nucleus-ENK (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Subcortical
FAM LMC.MM.RF.SUC FAM.FD.LHB.LT Lateral Habenula Lateral Part nucleus-nucleus-5HT (unknown reference)
FAM.FT.SEP.LT Lateral Septal Nucleus nucleus-nucleus-5HT (unknown reference)
FEC LMC.MM.RF.SUC FEC.FD.STN.ICD Subthalamic Nucleus Internal Caudal nucleus-nucleus-5HT (unknown reference)
FMM LMC.MM.RF.SUC FMM.FD.MB.MMB Medial Mammillary Nucleus nucleus-nucleus-5HT (unknown reference)
LAC LMC.MM.RF.SUC LAC.FD.HT.PN Posterior Hypothalamic Nucleus nucleus-nucleus-5HT (unknown reference)
LAC.FD.HT.SUM Supramammillary Nucleus nucleus-nucleus-5HT (unknown reference)
LLC LMC.HM.RP.OB LLC.HP.CR.SC Spinocerebellum nucleus-allocortex-5HT (unknown reference)
LMC.HP.RP.PRN LLC.HP.CR.SC Spinocerebellum nucleus-allocortex-5HT (unknown reference)
LPC LMC.HM.RP.MG LPC.SC.PH.LSG Lower Substantia Gelatinosa nucleus-nucleus-5HT (unknown reference)
LPC.SC.PH.USG Upper Substantia Gelatinosa nucleus-nucleus-5HT (unknown reference)
LMC.HM.RP.OB LPC.SC.IZ.IMM Intermediomedial Nucleus nucleus-nucleus-5HT (unknown reference)
LMC.HM.RP.PL LPC.SC.PH.LMG Lower Marginal Nucleus nucleus-nucleus-5HT (unknown reference)
LPC.SC.PH.UMG Upper Marginal Nucleus nucleus-nucleus-5HT (unknown reference)
LMC.MM.RP.DRN LPC.FD.TH.PV Paraventricular Nucleus of Thalamus nucleus-nucleus-5HT (unknown reference)

Acetylcholine - PNS Actions and CNS plasticity, arousal and reward

unavailable

Component ID Component Name Type Service Function Comments
LMC.FT.NBM Basal Nucleus of Meynert nucleus FAU Control imagination vs perception ACh source, attention; modulatory nucleus
LMC.HP.TG.DTG Dorsal Tegmental Nucleus nucleus LUS accurate landmark navigation vestibular sensory information to mammllary bodies
for orientation
LMC.HP.TG.LDT Laterodorsal Tegmental Nucleus nucleus LUS Modulating sustained attention or in mediating alerting responses sleep, waking, motor function, learning and reward
LMC.HP.TG.VTG Ventral Tegmental Nucleus nucleus LUS moderates hippocampal-driven rhythmic firing frequency in medial mammillary contribute to episodic memory and new learning in
humans as well as spatial memory

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NSA LMC.HP.TG.LDT NSA.FD.TH.SG Suprageniculate Nucleus of Thalamus nucleus-nucleus [Direction Cell Circuit (SUPGEN -> DTN)]
Subcortical
FAM LMC.FT.NBM FAM.FT.AM.AB Accessory Basal Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.AM.BP Parvicellular Basal Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.BNST Bed Nucleus of Stria Terminalis nucleus-nucleus (unknown reference)
LMC.HP.TG.DTG FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus (unknown reference)
LMC.HP.TG.LDT FAM.HP.PPN.RMTG Rostromedial Tegmental Nucleus nucleus-nucleus-gaba (unknown reference)
LMC.HP.TG.VTG FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus (unknown reference)
FEC LMC.FT.NBM FEC.FD.STN.CD Subthalamic Nucleus Caudal nucleus-nucleus (unknown reference)
FEC.FT.ACC.SH Nucleus Accumbens Shell nucleus-nucleus-gaba [basal ganglia circuit (NACC -> nBM, abstract)]
FMM LMC.HP.TG.LDT FMM.FD.MB.LMB Lateral Mammillary Nucleus nucleus-nucleus [Direction Cell Circuit (LMB -> DTN)]
LRC LMC.HP.TG.DTG LRC.HM.NPH Prepositus Nucleus nucleus-nucleus (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NDM LMC.FT.NBM NDM.NC.AL.FPC Lateral Frontopolar Cortex nucleus-neocortex-ACh [and pathophysiology of lower urinary tract (NBM -> MPFC, abstract)]
NSA LMC.FT.NBM NSA.NC.OCC.V1 Primary Visual Cortex nucleus-neocortex-ACh (unknown reference)
Subcortical
FAM LMC.FT.NBM FAM.FT.AM.BM Magnocellular Basal Amygdaloid Nucleus nucleus-nucleus-ACh (unknown reference)
LMC.HP.TG.LDT FAM.HP.PPN.IPD Interpeduncular Nucleus nucleus-nucleus-ACh [Direction Cell Circuit (DTN -> IPD)]
FMM LMC.HP.TG.DTG FMM.FD.MB.LMB Lateral Mammillary Nucleus nucleus-nucleus-ACh (unknown reference)
LMC.HP.TG.VTG FMM.FD.MB.MMB Medial Mammillary Nucleus nucleus-nucleus (unknown reference)
LAC LMC.HP.TG.LDT LAC.HM.SAL.ISL Inferior Salivatory Nucleus nucleus-nucleus-ACh (unknown reference)
LAC.HM.SAL.SSL Superior Salivatory Nucleus nucleus-nucleus-ACh (unknown reference)
LMC LMC.HP.TG.VTG LMC.MM.VTA Ventral Tegmental Area nucleus-nucleus (unknown reference)
LRC LMC.HP.TG.LDT LRC.HM.NPH Prepositus Nucleus nucleus-nucleus-ACh [Direction Cell Circuit (DTN -> NPRP)]

Dopamine - Reward-Motivated Behavior, Cognitive Alertness

unavailable

Component ID Component Name Type Service Function Comments
LMC.MM.VTA Ventral Tegmental Area nucleus LUS Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Subcortical
FAM LMC.MM.VTA FAM.FT.BNST Bed Nucleus of Stria Terminalis nucleus-nucleus (unknown reference)
FEC LMC.MM.VTA FEC.FT.ACC.CORE Nucleus Accumbens Core nucleus-nucleus-gaba [circuit of human brain (NACC -> VTA, abstract)]
LMC LMC.MM.VTA LMC.HP.TG.VTG Ventral Tegmental Nucleus nucleus-nucleus (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NDM LMC.MM.VTA NDM.NC.AL.DACG Dorsal Anterior Cingulate Area nucleus-neocortex-DA (unknown reference)
NDM.NC.AL.FPC Lateral Frontopolar Cortex nucleus-neocortex-DA [circuit of human brain (VTA -> PFC, abstract)]
Subcortical
FAM LMC.MM.VTA FAM.FT.AM.CEC Central Amygdaloid Nucleus, capsular subdivision nucleus-nucleus-DA [circuit of human brain (VTA -> AM, abstract)]
FEC LMC.MM.VTA FEC.FT.ACC.SH Nucleus Accumbens Shell nucleus-nucleus-DA [(VTA -> NACC, abstract)]
FMM LMC.MM.VTA FMM.FD.MB.MMB Medial Mammillary Nucleus nucleus-nucleus-DA [bodies: two memory systems in one (VTN -> MMB)]
FMM.FT.HC.CA1D Distal CA1 of Hippocampus nucleus-allocortex-DA [circuit of human brain (VTA -> HC, abstract)]
FMM.NC.PH.LEC Lateral Entorhinal Cortex nucleus-neocortex-DA [Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)]
LAC LMC.MM.VTA LAC.FD.HT.PO Preoptic Nucleus nucleus-nucleus-DA [and pathophysiology of lower urinary tract (VTA -> MPOA)]
LAC.FD.HT.PRM Premammillary Nucleus nucleus-nucleus-DA (unknown reference)
LAC.FD.HT.PV Paraventricular Nucleus nucleus-nucleus-DA [and pathophysiology of lower urinary tract (VTA -> PVN)]

Enkephalin - Regulating Nociception in Body

unavailable

Component ID Component Name Type Service Function Comments
LMC.MM.PAG Periaqueductal Gray Matter nucleus LUS Descending modulation of pain and in defensive behaviour if there is a lesion in the PAG, then consciousness
is lost; electrical stimulation of the PAG results
in immediate and profound analgesia; modulatory
nucleus

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NCP LMC.MM.PAG NCP.NC.AL.SGCG Subgenual Cingulate Cortex neocortex-nucleus (unknown reference)
Subcortical
FAM LMC.MM.PAG FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus-nucleus [disruption of prefrontal cortex (AM -> PAG, abstract)]
LAC LMC.MM.PAG LAC.FD.HT.VM Ventromedial Hypothalamic Nucleus nucleus-nucleus (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Subcortical
LAC LMC.MM.PAG LAC.HP.BR Barrington's Nucleus nucleus-nucleus-ENK [overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)]
LLC LMC.MM.PAG LLC.FD.TH.SF Subfascicular Nucleus of Thalamus nucleus-nucleus-ENK (unknown reference)
LMC LMC.MM.PAG LMC.HM.RP.MG Raphe Magnus Nucleus nucleus-nucleus-ENK (unknown reference)
LMC.HM.RP.PL Raphe Pallidus Nucleus nucleus-nucleus-ENK (unknown reference)
LPC LMC.MM.PAG LPC.FD.TH.PV Paraventricular Nucleus of Thalamus nucleus-nucleus-ENK (unknown reference)
LPC.HM.AMB Ambiguus Nucleus nucleus-nucleus-ENK (unknown reference)
LRC LMC.MM.PAG LRC.HM.RA Retroambigualis Nucleus nucleus-nucleus-ENK (unknown reference)
LRC.HP.PN.SC Nucleus Subceruleus nucleus-nucleus-ENK (unknown reference)

Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response

unavailable

Component ID Component Name Type Service Function Comments
LMC.HP.LC Locus Coeruleus nucleus LUS Regulate the intensity of responses to salient stimuli NE Source, enhance signal-to-noise ratio,
suppressing irrelevant stimuli (lateral
inhibition); inhibitory nucleus

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NDM LMC.HP.LC NDM.NC.AL.VACG Ventral Anterior Cingulate Area neocortex-nucleus [Control (Premotor24 -> RF, abstract)]
Subcortical
FAM LMC.HP.LC FAM.FT.BNST Bed Nucleus of Stria Terminalis nucleus-nucleus (unknown reference)
LAC LMC.HP.LC LAC.FD.HT.DM Dorsomedial Hypothalamic Nucleus nucleus-nucleus (unknown reference)
LAC.FD.HT.TBM Tuberomammillary Nucleus nucleus-nucleus (unknown reference)
LRC LMC.HP.LC LRC.HM.RF.MED Central Medullary Reticular Nucleus nucleus-nucleus (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Subcortical
FAM LMC.HP.LC FAM.FD.MHB Medial Habenula nucleus-nucleus-NE (unknown reference)
FAM.FT.SEP.DBB Diagonal Band of Broca nucleus-nucleus-NE (unknown reference)
FEC LMC.HP.LC FEC.FT.SNC.MED Substantia Nigra Pars Compacta Medial nucleus-nucleus-NE (unknown reference)
LAC LMC.HP.LC LAC.SC.IZ.IML Intermediolateral Nucleus nucleus-nucleus-NE [and pathophysiology of lower urinary tract (LC -> IML)]

Thirdparty Circuits

(generated)

unavailable

unavailable

unavailable

unavailable

unavailable

unavailable

unavailable

unavailable

unavailable

unavailable

unavailable

unavailable

unavailable

unavailable

unavailable

unavailable

unavailable


References

(generated)