Difference between revisions of "BrainRegionLMC MM PAG"
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* '''Top-down path to region''': Midbrain Mesencephalon -> [[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter]] (LMC.MM.PAG) (see [[OverallMindMaps|Mind Maps]]) | * '''Top-down path to region''': Midbrain Mesencephalon -> [[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter]] (LMC.MM.PAG) (see [[OverallMindMaps|Mind Maps]]) | ||
* '''Type''': nucleus | * '''Type''': nucleus | ||
| − | * '''Brain area''': [[BrainAreaLMC|Lower Brain - Modulatory Contol Area]] | + | * '''Quality''': L0 |
| + | * '''Brain area''': [[BrainAreaLMC|Lower Brain - Modulatory Contol Area]] (LMC) | ||
| + | * '''Area circuit''': Enkephalin - Regulating Nociception in Body (ENK) | ||
* '''Role''': processor.autonomic | * '''Role''': processor.autonomic | ||
* '''Function''': Descending modulation of pain and in defensive behaviour | * '''Function''': Descending modulation of pain and in defensive behaviour | ||
| − | * '''Notes to function''': if there is a lesion in the PAG, then consciousness is lost | + | * '''Notes to function''': |
| + | ** if there is a lesion in the PAG, then consciousness is lost | ||
| + | ** electrical stimulation of the PAG results in immediate and profound analgesia | ||
| + | ** modulatory nucleus | ||
(generated) | (generated) | ||
= Components = | = Components = | ||
| Line 28: | Line 33: | ||
{| class=wikitable width=80% | {| class=wikitable width=80% | ||
| − | | '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference''' | + | | '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Role''' || '''Reference''' |
|- | |- | ||
| − | | [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || excitatory-glu || [http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)] | + | | [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || excitatory-glu || uncertain ||[http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)] |
|- | |- | ||
| − | | [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || modulatory-ach || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (IPN -> PAG)] | + | | [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || modulatory-ach || uncertain ||[http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (IPN -> PAG)] |
|- | |- | ||
| − | | [[BrainAreaNCP|NCP]] || [[BrainRegionNCP_NC_AL_SGCG|NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || excitatory-glu || (unknown reference) | + | | [[BrainAreaNCP|NCP]] || [[BrainRegionNCP_NC_AL_SGCG|NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || excitatory-glu || uncertain ||(unknown reference) |
|} | |} | ||
| Line 40: | Line 45: | ||
{| class=wikitable width=80% | {| class=wikitable width=80% | ||
| − | | '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference''' | + | | '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Role''' || '''Reference''' |
|- | |- | ||
| − | | [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_HT_BR|LAC.HT.BR]] || Barrington's Nucleus || modulatory-enk || [http://jp.physoc.org/content/557/1/287/F9.expansion.html Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)] | + | | [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_HT_BR|LAC.HT.BR]] || Barrington's Nucleus || modulatory-enk || uncertain || [http://jp.physoc.org/content/557/1/287/F9.expansion.html Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)] |
|- | |- | ||
| − | | [[BrainAreaLLC|LLC]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || modulatory-enk || (unknown reference) | + | | [[BrainAreaLLC|LLC]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || modulatory-enk || uncertain || (unknown reference) |
|- | |- | ||
| − | | [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || Raphe Magnus Nucleus || modulatory-enk || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)] | + | | [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || Raphe Magnus Nucleus || modulatory-enk || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)] |
|- | |- | ||
| − | | || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || Raphe Pallidus Nucleus || modulatory-enk || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)] | + | | || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || Raphe Pallidus Nucleus || modulatory-enk || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)] |
|- | |- | ||
| − | | [[BrainAreaLPC|LPC]] || [[BrainRegionLPC_HL_AMB|LPC.HL.AMB]] || Ambiguus Nucleus || modulatory-enk || (unknown reference) | + | | [[BrainAreaLPC|LPC]] || [[BrainRegionLPC_HL_AMB|LPC.HL.AMB]] || Ambiguus Nucleus || modulatory-enk || uncertain || (unknown reference) |
|- | |- | ||
| − | | [[BrainAreaLRC|LRC]] || [[BrainRegionLRC_HL_RA|LRC.HL.RA]] || Retroambigualis Nucleus || modulatory-enk || (unknown reference) | + | | [[BrainAreaLRC|LRC]] || [[BrainRegionLRC_HL_RA|LRC.HL.RA]] || Retroambigualis Nucleus || modulatory-enk || uncertain || (unknown reference) |
|- | |- | ||
| − | | || [[BrainRegionLRC_HT_NSC|LRC.HT.NSC]] || Nucleus Subceruleus || modulatory-enk || (unknown reference) | + | | || [[BrainRegionLRC_HT_NSC|LRC.HT.NSC]] || Nucleus Subceruleus || modulatory-enk || uncertain || (unknown reference) |
|- | |- | ||
| − | | [[BrainAreaNDM|NDM]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || modulatory-enk || (unknown reference) | + | | [[BrainAreaNDM|NDM]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || modulatory-enk || uncertain || (unknown reference) |
|} | |} | ||
Latest revision as of 18:29, 28 April 2019
Periaqueductal Gray Matter
@@Home -> BiologicalLifeResearch -> BrainAreaLMC -> BrainRegionLMC_MM_PAG
This page covers biological details of component Periaqueductal Gray Matter. Region is part of aHuman target integrated biological model.
- Top-down path to region: Midbrain Mesencephalon -> Periaqueductal Gray Matter (LMC.MM.PAG) (see Mind Maps)
- Type: nucleus
- Quality: L0
- Brain area: Lower Brain - Modulatory Contol Area (LMC)
- Area circuit: Enkephalin - Regulating Nociception in Body (ENK)
- Role: processor.autonomic
- Function: Descending modulation of pain and in defensive behaviour
- Notes to function:
- if there is a lesion in the PAG, then consciousness is lost
- electrical stimulation of the PAG results in immediate and profound analgesia
- modulatory nucleus
(generated)
Components
(generated)
- no child items defined
Connectivity
(generated)
Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Role | Reference |
| FAM | FAM.FT.AM.CEM | Medial Central Amygdaloid Nucleus | excitatory-glu | uncertain | Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract) |
| FEC | FEC.HT.TG.IPD | Interpeduncular Nucleus | modulatory-ach | uncertain | Connectivity map of the habenula (IPN -> PAG) |
| NCP | NCP.NC.AL.SGCG | Subgenual Cingulate Cortex | excitatory-glu | uncertain | (unknown reference) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Role | Reference |
| LAC | LAC.HT.BR | Barrington's Nucleus | modulatory-enk | uncertain | Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR) |
| LLC | LLC.FD.TH.SF | Subfascicular Nucleus of Thalamus | modulatory-enk | uncertain | (unknown reference) |
| LMC | LMC.HL.RP.MG | Raphe Magnus Nucleus | modulatory-enk | uncertain | Connectivity map of the habenula (PAG -> Raphe, abstract) |
| LMC.HL.RP.PL | Raphe Pallidus Nucleus | modulatory-enk | uncertain | Connectivity map of the habenula (PAG -> Raphe, abstract) | |
| LPC | LPC.HL.AMB | Ambiguus Nucleus | modulatory-enk | uncertain | (unknown reference) |
| LRC | LRC.HL.RA | Retroambigualis Nucleus | modulatory-enk | uncertain | (unknown reference) |
| LRC.HT.NSC | Nucleus Subceruleus | modulatory-enk | uncertain | (unknown reference) | |
| NDM | NDM.FD.TH.PV | Paraventricular Nucleus of Thalamus | modulatory-enk | uncertain | (unknown reference) |
Thirdparty Circuits
(generated)
- Schematic overview of spinobulbospinal micturition reflex pathway - see Reference (CM.BARRINGTON)
BAR=Barrington's Nucleus,LAC.HT.BR IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG IML=Intermediolateral Nucleus,LAC.SC.IZ.IML ONF=Onuf's Nucleus,LPC.SC.VH.ONF PAG=Periaqueductal Gray Matter,LMC.MM.PAG PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS
- Connectivity map of the habenula - see Reference (CF.HB-CONN)
CPu=Striatum,FEC.FT.ST (see Basal Ganglia) EP=Endopiriform Nucleus,FAM.FT.EPF Hippo=Hippocampus,FMM.FT.HC (see Hippocampal Formation) IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD L=Lateral Habenula,FAM.FD.LHB (see Habenula) LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN M=Medial Habenula,FAM.FD.MHB NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) PAG=Periaqueductal Gray Matter,LMC.MM.PAG Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) Septum=Septal Nuclei,FAM.FT.SEP VTA=Ventral Tegmental Area,LMC.MM.VTA
- Spine induction on short primary dendrites in the ventrolateral VMH - see Reference (CL.VMH-PAG)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM
- Afferent pain pathways - see Reference (CF.PAIN-PATH)
ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area) AMY=Amygdala,FAM.FT.AM BG=Basal Ganglia,FEC.FT.BG Cerebellum=Cerebellar Complex,LLC.HT.CRC Insula=Insular Cortex,NC.INS PAG=Periaqueductal Gray Matter,LMC.MM.PAG PB=Parabrachial Nucleus,LPC.HT.PRF.PB PFC=Prefrontal Cortex,NC.AL.PFC S1=Primary Somatosensory Cortex,NCP.NC.PG.S1 S2=Secondary Somatosensory Cortex,NCP.NC.PG.S2 SC=Posterior/Dorsal Horn,BMA.SC.PH Thalamus=Sensory Thalamus,FD.TH.SR
- Pain matrix - see Reference (CF.PAIN-MATRIX)
ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area) AM=Amygdala,FAM.FT.AM INS=Insular Cortex,NC.INS PAG=Periaqueductal Gray Matter,LMC.MM.PAG PFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) PPC=Superior Parietal Lobule,NC.SPL S1=Primary Somatosensory Cortex,NCP.NC.PG.S1 SMA=Supplementary Motor Cortex,NMA.NC.SMC TH=Thalamus,FD.TH
- Amygdala and its network - see Reference (CF.AM-NET)
BLN=Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP CEA=Central Amygdala,FAM.FT.AM.CEA (see Amygdala) EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex) HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation) HTS=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN ITC=Inferotemporal Cortex,NSA.NC.IT.TE LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see Amygdala) LHB=Lateral Habenula,FAM.FD.LHB (see Habenula) MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus) MPFC=Orbitomedial Prefrontal Cortex,NC.AL.OMPFC NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia) PAG=Periaqueductal Gray Matter,LMC.MM.PAG RMTG=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG STC=Wernicke's area A3,NSA.NC.STG.A3 VGDM=Vagus Nucleus,LAC.HL.VGN VTA=Ventral Tegmental Area,LMC.MM.VTA
- Amygdalar disruption of prefrontal cortex - see Reference (CF.AM-DISRUPTION)
ACG=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area) AM=Amygdala,FAM.FT.AM HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation) HT.L=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus) HT.PV=Paraventricular Nucleus,LAC.FD.HT.PV INS=Insular Cortex,NC.INS LC=Locus Coeruleus,LMC.HT.LC MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) PAG=Periaqueductal Gray Matter,LMC.MM.PAG PB=Parabrachial Nucleus,LPC.HT.PRF.PB PUT=Endocrine Glands,TARGET.TEA.ENDOCRINE SOL=Solitary Nucleus,LPC.HL.SOL TH=Thalamus,FD.TH
References
(generated)
- http://jp.physoc.org/content/557/1/287/F9.expansion.html
- http://jn.physiology.org/content/107/10/2633
- http://www.jneurosci.org/content/20/4/1589/F9.expansion
- http://www.nature.com/nrn/journal/v14/n7/fig_tab/nrn3516_F2.html
- http://www.springerimages.com/Images/MedicineAndPublicHealth/1-10.1007_s10194-006-0307-1-0
- http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin
- http://neuropolitics.org/defaultmay10.asp
