BrainRegionFMM NC PH MEC

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Medial Entorhinal Cortex

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This page covers biological details of component Medial Entorhinal Cortex. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Cerebral Cortex -> Parahippocampal Lobe (NC.LOBE.PH) -> Anterior Parahippocampal Gyrus (FMM.NC.PHA) -> Rhinal Cortex (NC.PHA.RH) -> Entorhinal Cortex (FMM.NC.PH.ET) -> Medial Entorhinal Cortex (FMM.NC.PH.MEC) (see Mind Maps)
  • Type: cortex
  • Brain area: Forebrain - Memory Management Area
  • Brodmann ID: 28
  • Role: processor.memory.complex
  • Function: Memory consolidation, basic, view independent position
  • Notes to function: spatial input to HC; grid cells; path integration computations based on a global frame of reference, primarily using internally generated, self-motion cues and external input about environmental boundaries and scenes; provides hippocampus with coordinate system that underlies spatial context of experience

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Components

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  • no child items defined

Connectivity

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FMM.NC.PH.MEC.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FMM FMM.FT.HF.SUBD Distal Subiculum excitatory-glu Attractor Network in Hippocampus (SUB -> EC, abstract)
FMM.NC.PH.PAS Parasubiculum feedforward-glu (unknown reference)
FMM.NC.PH.POR Postrhinal Cortex feedforward-glu Entorhinal Cortex Inputs and Outputs (TFTH -> EC, abstract)
FMM.NC.PH.POS Postsubiculum feedforward-glu Head Direction Cell Circuit (PSUB -> EC, abstract)
FMM.NC.PH.PRS Presubiculum feedforward-glu Attractor Network in Hippocampus (PRESUB -> EC, abstract)
NCP NCP.NC.MPL.PSCG Posterior Cingulate Cortex feedforward-glu McNaughton Spatial Processing Network (PCGRSP -> EnthCortex, abstract)
NCP.NC.MPL.RSC Retrosplenial Cortex feedforward-glu McNaughton Spatial Processing Network (PCGRSP -> EnthCortex, abstract)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FMM FMM.FD.MB.MMB Medial Mammillary Nucleus excitatory-glu Mammillary bodies: two memory systems in one (MedialEC -> MMB, abstract)
FMM.FD.TH.AV Anteroventral Nucleus excitatory-glu Contributions of Diencephalon to Recognition Memory (EC -> AN, abstract)
FMM.FD.TH.LD Lateral Dorsal Nucleus of Thalamus excitatory-glu Contributions of Diencephalon to Recognition Memory (EC -> LD, abstract)
FMM.FT.HC.CA1P Proximal CA1 of Hippocampus excitatory-glu Neuronal projections in the hippocampus (ET -> CA1, abstract)
FMM.FT.HC.CA2 Dorsolateral Cornu Ammonis of Hippocampus excitatory-glu Amygdala and its network (EC -> HC, abstract)
FMM.FT.HC.CA3D Distal CA3 of Hippocampus excitatory-glu Neuronal projections in the hippocampus (ET -> CA3, abstract)
FMM.FT.HC.DG Dentate Gyrus excitatory-glu Neuronal projections in the hippocampus (ET -> DG, abstract)

Thirdparty Circuits

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map: AD=Anterodorsal Nucleus,FMM.FD.TH.AD, AM=Anteromedial Nucleus,NCP.FD.TH.AM, AN=Anterior Nucleus of Thalamus,FD.TH.AN (Anteromedial Nucleus (NCP.FD.TH.AM), Anteroventral Nucleus (FMM.FD.TH.AV), Anterodorsal Nucleus (FMM.FD.TH.AD)), AV=Anteroventral Nucleus,FMM.FD.TH.AV, CM=Centromedian Nucleus of Thalamus,FEC.FD.TH.CM, DLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (Rostral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCR), Lateral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCL)), EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), HC=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD, MB=Medial Mammillary Nucleus,FMM.FD.MB.MMB, MDmc=Mediodorsal Nucleus of Thalamus,FD.TH.MD (Medial Mediodorsal Nucleus of Thalamus (NDM.FD.TH.MDM), Central Mediodorsal Nucleus of Thalamus (NCP.FD.TH.MDC), Lateral Mediodorsal Nucleus of Thalamus (NMA.FD.TH.MDL)), MID=Midline Nuclear Group of Thalamus,FD.TH.MTH (Paratenial Nucleus of Thalamus (FAM.FD.TH.PT), Paraventricular Nucleus of Thalamus (NDM.FD.TH.PV), Reuniens Nucleus of Thalamus (FMM.FD.TH.RE), Rhomboidal Nucleus of Thalamus (FMM.FD.TH.RH), Subfascicular Nucleus of Thalamus (LLC.FD.TH.SF)), MPFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)), OFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)), Parasub=Parasubiculum,FMM.NC.PH.PAS, Perirhinal=Perirhinal Cortex,FMM.NC.PH.PER, PostCingulate=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG, Presub=Presubiculum,FMM.NC.PH.PRS, Sub=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), SubPrePara=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), mPULV=Medial Pulvinar,NPE.FD.TH.MPV unavailable

map: ADTH=Anterodorsal Nucleus,FMM.FD.TH.AD, AMTH=Anteromedial Nucleus,NCP.FD.TH.AM, AVTH=Anteroventral Nucleus,FMM.FD.TH.AV, DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT, LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB, MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB, MedialEC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), PAS=Parasubiculum,FMM.NC.PH.PAS, POS=Postsubiculum,FMM.NC.PH.POS, PRS=Presubiculum,FMM.NC.PH.PRS, SEP=Septal Nuclei,FAM.FT.SEP, SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM, TuberoMM=Lateral Tuberal Nuclei,LAC.FD.HT.LTUB (Supramammillary Nucleus (LAC.FD.HT.SUM), Tuberomammillary Nucleus (LAC.FD.HT.TBM), Premammillary Nucleus (LAC.FD.HT.PRM)), VTN=Ventral Tegmental Area,LMC.MM.VTA unavailable

map: AD=Anterodorsal Nucleus,FMM.FD.TH.AD, DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), HC=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), IPD=Interpeduncular Nucleus,FEC.HT.TG.IPD, LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD, LHAB=Habenula,FAM.FD.HB, LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB, MVSN=Medial Vestibular Nucleus,LPC.HT.MVBN, NPRP=Prepositus Nucleus,LRC.HL.NPH, PC=Parietal Lobe,NC.LOBE.PAR (Medial Superior Temporal Area (NPE.NC.IPL.MST), Supramarginal Wernike Cortex (NPE.NC.IPL.SMW), Retrosplenial Cortex (NCP.NC.MPL.RSC), Posterior Cingulate Cortex (NCP.NC.MPL.PSCG), Subgenual Cingulate Cortex (NCP.NC.MPL.SGCG), Precentral Cortex (NCP.NC.PO.PCC), Primary Somatosensory Cortex (NCP.NC.PG.S1), Secondary Somatosensory Cortex (NCP.NC.PG.S2), Parietal Ventral Cortex (NCP.NC.PG.PV), Somatosensory Association Cortex (NCP.NC.SPL.SA), Rostral Precuneus (NPE.NC.SPL.PF), Caudal Precuneus (NPE.NC.SPL.PG), Medial Intraparietal Sulcus (NPE.NC.IPS.MIP), Lateral Intraparietal Sulcus (NPE.NC.IPS.LIP), Ventral Intraparietal Sulcus (NSA.NC.IPS.VIP), Anterior Intraparietal Sulcus (NSA.NC.IPS.AIP)), PRHC=Postrhinal Cortex,FMM.NC.PH.POR, PSUB=Postsubiculum,FMM.NC.PH.POS, RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC, SUPGEN=Suprageniculate Nucleus of Thalamus,NSA.FD.TH.SG, VC=Occipital Lobe,NC.LOBE.OCC unavailable

map: EnthCortex=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), HF=Hippocampal Formation,FMM.FT.HF, ITCortex=Inferotemporal Area,NSA.NC.IT, PCGRSP=Medial Parietal Lobule,NC.MPL, ParInsVestCortex=Ventral Intraparietal Sulcus,NSA.NC.IPS.VIP, PosteriorParietalCortex=Caudal Precuneus,NPE.NC.SPL.PG, SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), SomSensCortex=Primary Somatosensory Cortex,NCP.NC.PG.S1, VisualCortex=Occipital Lobe,NC.LOBE.OCC unavailable

map: A=Amygdala,FAM.FT.AM, ER=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), H=Hippocampal Formation,FMM.FT.HF, IT=Inferotemporal Cortex,NSA.NC.IT.TE, PRPH=Perirhinal Cortex,FMM.NC.PH.PER, TEO=Preoccipital Inferotemporal Area,NSA.NC.IT.TEO, V1=Primary Visual Cortex,NSA.NC.OCC.V1, V2=Secondary Visual Cortex,NSA.NC.OCC.V2 (Secondary Visual Cortex, Thin Stripe (NSA.NC.OCC.V2TN), Secondary Visual Cortex, Thick Stripe (NSA.NC.OCC.V2TK), Secondary Visual Cortex, Pale Stripe (NPE.NC.OCC.V2PL)), V4=Fusiform Gyrus,NSA.NC.OCC.V4 (Dorsal Visual Area V4 (NSA.NC.OCC.V4D), Ventral Visual Area V4 (NSA.NC.OCC.V4V)) unavailable

map: BLN=Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP, CEA=Central Amygdala,FAM.FT.AM.CEA (Central Amygdaloid Nucleus, capsular subdivision (FAM.FT.AM.CEC), Central Amygdaloid Nucleus, lateral subdivision (FAM.FT.AM.CEL), Medial Central Amygdaloid Nucleus (FAM.FT.AM.CEM)), EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), HC=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), HTS=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, ITC=Inferotemporal Cortex,NSA.NC.IT.TE, LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (Dorsolateral Amygdaloid Nucleus (FAM.FT.AM.LADL), Ventrolateral Amygdaloid Nucleus (FAM.FT.AM.LAVL), Ventromedial Amygdaloid Nucleus (FAM.FT.AM.LAVM)), LHB=Lateral Habenula,FAM.FD.LHB (Lateral Habenula Medial Part (FAM.FD.LHB.MED), Lateral Habenula Lateral Part (FAM.FD.LHB.LT)), MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (Medial Mediodorsal Nucleus of Thalamus (NDM.FD.TH.MDM), Central Mediodorsal Nucleus of Thalamus (NCP.FD.TH.MDC), Lateral Mediodorsal Nucleus of Thalamus (NMA.FD.TH.MDL)), MPFC=Orbitomedial Prefrontal Cortex,NC.AL.OMPFC, NACC=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), PAG=Periaqueductal Gray Matter,LMC.MM.PAG, RMTG=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG, STC=Wernicke's area A3,NSA.NC.STG.A3, VGDM=Vagus Nucleus,LAC.HL.VGN, VTA=Ventral Tegmental Area,LMC.MM.VTA unavailable

map: BLA=Basolateral Nuclear Complex,FAM.FT.AM.BL (Dorsolateral Amygdaloid Nucleus (FAM.FT.AM.LADL), Ventrolateral Amygdaloid Nucleus (FAM.FT.AM.LAVL), Ventromedial Amygdaloid Nucleus (FAM.FT.AM.LAVM), Parvicellular Basal Amygdaloid Nucleus (FAM.FT.AM.BP), Magnocellular Basal Amygdaloid Nucleus (FAM.FT.AM.BM), Accessory Basal Amygdaloid Nucleus (FAM.FT.AM.AB)), CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), DG=Dentate Gyrus,FMM.FT.HC.DG, ET=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)) unavailable


References

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