BrainCenterNC AL LPFC

Lateral Prefrontal Cortex

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This page covers biological details of component group Lateral Prefrontal Cortex. Component group is part of aHuman target integrated biological model.

• Top-down path to center: Cerebral Cortex -> Anterior Lobe (NC.LOBE.ANT) -> Prefrontal Cortex (NC.AL.PFC) -> Lateral Prefrontal Cortex (NC.AL.LPFC) (see Mind Maps)
• Function: High-level Rational Thinking Functions

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Components

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Component items:

• Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFC): Temporal Integration and working memory
  • Rostral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCR): Cognitive control and monitoring to resolve conflict in information processing and competing response plans
  • Lateral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCL): Cognitive control related to stimulus processing and selection of relevant information for behavior
• Ventrolateral Prefrontal Cortex (NC.AL.VLPFC)
  • Inferior Prefrontal Gyrus (NDM.NC.AL.IPG): Processing of syntax in oral and sign languages
  • Broca's Area (NPE.NC.PFC.BRA): Speech Engine
    • Broca's Area Pars Opercularis (NPE.NC.BRA.PO): Speech Engine
    • Broca's Area Pars Triangularis (NPE.NC.BRA.PT): Language production and prefrontal associational integration, propositional language comprehension

Connectivity

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Internal Regions Connections:

Source Region	Target Region	Reference
Inferior Prefrontal Gyrus (NDM.NC.AL.IPG)	Lateral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCL)	Directed Effort Network (fPole -> DLPFC, abstract)

External Connections:

External Inbound Center Connections:

Source Center	Sample Link	Reference
Cognitive Thalamus (FD.TH.CR)	NDM.FD.TH.MDM -> NDM.NC.AL.DLPFCR	Prefrontal Cortex (PFC) in emotional behavior (TH -> LPFC, abstract)
Sensory Thalamus (FD.TH.SR)	NPE.FD.TH.MPV -> NDM.NC.AL.DLPFCL	Saccadic Vision (Thalamus -> FrontalCortex, abstract)
Cerebellar Complex (LLC.HT.CRC)	LLC.HT.CR.DN -> NDM.NC.AL.DLPFCL	(unknown reference)
Anterior Cingulate Area (NC.ACG)	NDM.NC.AL.VACG -> NDM.NC.AL.DLPFCR	Role for serotonin in moral behavior (ACG -> LPFC, abstract)
Orbitomedial Prefrontal Cortex (NC.AL.OMPFC)	NDM.NC.AL.FPC -> NDM.NC.AL.DLPFCR	Prefrontal Cortex (PFC) in emotional behavior (OPFC -> LPFC, abstract)
Insular Cortex (NC.INS)	NCP.NC.INS.AIC -> NDM.NC.AL.IPG	Directed Effort Network (Insula -> fPole, abstract)
Inferior Parietal Lobule (NC.IPL)	NPE.NC.IPL.MST -> NDM.NC.AL.DLPFCR	Cortico-Cortical Connectivity (PTHA -> PFC, abstract)
Occipital Lobe (NC.LOBE.OCC)	NSA.NC.OCC.V2TN -> NDM.NC.AL.DLPFCL	Cortico-Cortical Connectivity (VA -> PFC, abstract)
Medial Parietal Lobule (NC.MPL)	NCP.NC.MPL.RSC -> NDM.NC.AL.DLPFCR	Prefrontal Cortex (PFC) in emotional behavior (PCA -> LPFC, abstract)
Premotor Cortex (NC.PMC)	NMA.NC.PMC.F4 -> NDM.NC.AL.DLPFCL	Cortico-Cortical Connectivity (MA -> PFC, abstract)
Superior Temporal Gyrus (NC.STG)	NCP.NC.TPC -> NDM.NC.AL.IPG	Language-Related Regions (TC -> vIFC)
Intraparietal Sulcus (NSA.NC.IPS)	NPE.NC.IPS.LIP -> NDM.NC.AL.DLPFCR	Summary of eye movement control (PEF -> DLPFC, abstract)
Inferotemporal Area (NSA.NC.IT)	NSA.NC.IT.TE -> NDM.NC.AL.DLPFCL	3 Visual Cortex Paths (IT -> LPC, abstract)

External Outbound Center Connections:

Target Center	Sample Link	Reference
Motor Thalamus (FD.TH.MR)	NDM.NC.AL.DLPFCL -> NMA.FD.TH.VA	Prefrontal Cortex (PFC) in motor behavior (LPFC -> TH, abstract)
Basal Ganglia (FEC.FT.BG)	NDM.NC.AL.DLPFCL -> FEC.FT.CN.HD	Global visual system (FrontalCortex -> BGA, abstract)
Pontine Reticular Formation (HT.RF)	NPE.NC.BRA.PO -> LLC.HT.PRF.PDT	Cerebellum functional divisions (CTX -> PNN, abstract)
Anterior Cingulate Area (NC.ACG)	NDM.NC.AL.DLPFCR -> NDM.NC.AL.DACG	Prefrontal Cortex (PFC) in emotional behavior (LPFC -> ACG, abstract)
Orbitomedial Prefrontal Cortex (NC.AL.OMPFC)	NDM.NC.AL.DLPFCR -> NDM.NC.AL.VMPFC	Fear regulation (dlPFC -> vmPFC, abstract)
Inferior Parietal Lobule (NC.IPL)	NPE.NC.BRA.PT -> NPE.NC.IPL.SMW	Cortical Auditory System (IFC44 -> IPL40, abstract)
Premotor Cortex (NC.PMC)	NDM.NC.AL.DLPFCL -> NMA.NC.PMC.AFEF	Prefrontal Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)
Supplementary Motor Cortex (NMA.NC.SMC)	NDM.NC.AL.DLPFCR -> NMA.NC.SMC.F6	Primate Control of Grasping (46 -> F6, abstract)