Difference between revisions of "BrainCenterHT RF"

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*** [[BrainRegionLRC_HT_PRF_PVR|Parvocellular Reticular Nucleus]] (LRC.HT.PRF.PVR): Flow of respiratory current out of organism
 
*** [[BrainRegionLRC_HT_PRF_PVR|Parvocellular Reticular Nucleus]] (LRC.HT.PRF.PVR): Flow of respiratory current out of organism
 
* '''Pontine Reticular Formation, Lateral Column''' (HT.RF.LAT)
 
* '''Pontine Reticular Formation, Lateral Column''' (HT.RF.LAT)
** [[BrainRegionLLC_HT_PRF_PDT|Pontine Reticulotegmental Nucleus]] (LLC.HT.PRF.PDT): Mediate saccadic eye movements
+
** [[BrainRegionLLC_HT_PRF_RTMG|Pontine Reticulotegmental Nucleus]] (LLC.HT.PRF.RTMG): Mediate saccadic eye movements
 
** [[BrainRegionLPC_HT_PRF_PB|Parabrachial Nucleus]] (LPC.HT.PRF.PB): Source of short-latency nociceptive input; sense of physiological condition of body well-being or interoception
 
** [[BrainRegionLPC_HT_PRF_PB|Parabrachial Nucleus]] (LPC.HT.PRF.PB): Source of short-latency nociceptive input; sense of physiological condition of body well-being or interoception
  
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| [[BrainCenterFAM_FT_CEAM|Central Extended Amygdala]] (FAM.FT.CEAM) || [[BrainRegionFAM_FT_IPAC_MED|FAM.FT.IPAC.MED]] -> [[BrainRegionLPC_HT_PRF_PB|LPC.HT.PRF.PB]]||(unknown reference)
 
| [[BrainCenterFAM_FT_CEAM|Central Extended Amygdala]] (FAM.FT.CEAM) || [[BrainRegionFAM_FT_IPAC_MED|FAM.FT.IPAC.MED]] -> [[BrainRegionLPC_HT_PRF_PB|LPC.HT.PRF.PB]]||(unknown reference)
 
|-
 
|-
| [[BrainCenterFD_HT|Hypothalamus]] (FD.HT) || [[BrainRegionFMM_FD_MB_LMB|FMM.FD.MB.LMB]] -> [[BrainRegionLLC_HT_PRF_PDT|LLC.HT.PRF.PDT]]||[http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/mb.jpg Mammillary Body (LMB -> RTG)]
+
| [[BrainCenterFD_HT|Hypothalamus]] (FD.HT) || [[BrainRegionFMM_FD_MB_LMB|FMM.FD.MB.LMB]] -> [[BrainRegionLLC_HT_PRF_RTMG|LLC.HT.PRF.RTMG]]||[http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/mb.jpg Mammillary Body (LMB -> RTG)]
 
|-
 
|-
 
| [[BrainCenterFEC_FT_BG|Basal Ganglia]] (FEC.FT.BG) || [[BrainRegionFEC_FT_SNC_MED|FEC.FT.SNC.MED]] -> [[BrainRegionLRC_HT_PRF_PVR|LRC.HT.PRF.PVR]]||(unknown reference)
 
| [[BrainCenterFEC_FT_BG|Basal Ganglia]] (FEC.FT.BG) || [[BrainRegionFEC_FT_SNC_MED|FEC.FT.SNC.MED]] -> [[BrainRegionLRC_HT_PRF_PVR|LRC.HT.PRF.PVR]]||(unknown reference)
 
|-
 
|-
| [[BrainCenterHL_SN|Myelencephalic Sensory Nuclei]] (HL.SN) || [[BrainRegionLPC_HL_TGS_STR|LPC.HL.TGS.STR]] -> [[BrainRegionLLC_HT_PRF_PDT|LLC.HT.PRF.PDT]]||[http://neuroscience.uth.tmc.edu/s3/chapter07.html Eye blink reflex and pupillary light reflex (SpinalTrigeminal -> RF, abstract)]
+
| [[BrainCenterHL_SN|Myelencephalic Sensory Nuclei]] (HL.SN) || [[BrainRegionLPC_HL_TGS_STR|LPC.HL.TGS.STR]] -> [[BrainRegionLLC_HT_PRF_RTMG|LLC.HT.PRF.RTMG]]||[http://neuroscience.uth.tmc.edu/s3/chapter07.html Eye blink reflex and pupillary light reflex (SpinalTrigeminal -> RF, abstract)]
 
|-
 
|-
| [[BrainCenterLLC_HT_CRC|Cerebellar Complex]] (LLC.HT.CRC) || [[BrainRegionLLC_HT_CR_FN|LLC.HT.CR.FN]] -> [[BrainRegionLRC_HT_PRF_CRF|LRC.HT.PRF.CRF]]||(unknown reference)
+
| [[BrainCenterLLC_HT_CRC|Cerebellar Complex]] (LLC.HT.CRC) || [[BrainRegionLRC_HT_CR_FG|LRC.HT.CR.FG]] -> [[BrainRegionLRC_HT_PRF_CRF|LRC.HT.PRF.CRF]]||[http://instruct.uwo.ca/anatomy/530/cblm.htm Cerebellum functional divisions (FG -> RF, abstract)]
 
|-
 
|-
 
| [[BrainCenterLPC_HT_VBN|Vestibular Nuclei]] (LPC.HT.VBN) || [[BrainRegionLPC_HT_IVBN|LPC.HT.IVBN]] -> [[BrainRegionLRC_HT_PRF_CRF|LRC.HT.PRF.CRF]]||[http://www.neuroanatomy.wisc.edu/virtualbrain/BrainStem/13VNAN.html Vestibulo-ocular reflex (VOR) (VestibularNuclei -> PPRF, abstract)]
 
| [[BrainCenterLPC_HT_VBN|Vestibular Nuclei]] (LPC.HT.VBN) || [[BrainRegionLPC_HT_IVBN|LPC.HT.IVBN]] -> [[BrainRegionLRC_HT_PRF_CRF|LRC.HT.PRF.CRF]]||[http://www.neuroanatomy.wisc.edu/virtualbrain/BrainStem/13VNAN.html Vestibulo-ocular reflex (VOR) (VestibularNuclei -> PPRF, abstract)]
 
|-
 
|-
| [[BrainCenterMM_REF|Reflexes Nuclei of Midbrain Mesencephalon]] (MM.REF) || [[BrainRegionLRC_MM_SC_DEEP|LRC.MM.SC.DEEP]] -> [[BrainRegionLLC_HT_PRF_PDT|LLC.HT.PRF.PDT]]||[http://www.sciencedirect.com/science/article/pii/S0387760401003308 Geniculate and Extyrageniculate Paths (SC -> RF, abstract)]
+
| [[BrainCenterMM_REF|Reflexes Nuclei of Midbrain Mesencephalon]] (MM.REF) || [[BrainRegionLRC_MM_SC_DEEP|LRC.MM.SC.DEEP]] -> [[BrainRegionLLC_HT_PRF_RTMG|LLC.HT.PRF.RTMG]]||[http://www.sciencedirect.com/science/article/pii/S0387760401003308 Geniculate and Extyrageniculate Paths (SC -> RF, abstract)]
 
|-
 
|-
| [[BrainCenterMM_RF|Mesencephalic Reticular Formation]] (MM.RF) || [[BrainRegionLLC_MM_SCNF|LLC.MM.SCNF]] -> [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]]||(unknown reference)
+
| [[BrainCenterMM_RF|Mesencephalic Reticular Formation]] (MM.RF) || [[BrainRegionLRC_MM_SCNF|LRC.MM.SCNF]] -> [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]]||(unknown reference)
 
|-
 
|-
| [[BrainCenterNC_ACG|Anterior Cingulate Area]] (NC.ACG) || [[BrainRegionNDM_NC_AL_VACG|NDM.NC.AL.VACG]] -> [[BrainRegionLLC_HT_PRF_PDT|LLC.HT.PRF.PDT]]||[http://instruct.uwo.ca/anatomy/530/cblm.htm Cerebellum functional divisions (CTX -> PNN, abstract)]
+
| [[BrainCenterNC_ACG|Anterior Cingulate Area]] (NC.ACG) || [[BrainRegionNDM_NC_AL_VACG|NDM.NC.AL.VACG]] -> [[BrainRegionLLC_HT_PRF_RTMG|LLC.HT.PRF.RTMG]]||[http://openagrosrl.com/www/page/292/ Motor neurons control (CTX -> PRF, abstract)]
 
|-
 
|-
| [[BrainCenterNC_AL_LPFC|Lateral Prefrontal Cortex]] (NC.AL.LPFC) || [[BrainRegionNPE_NC_BRA_PO|NPE.NC.BRA.PO]] -> [[BrainRegionLLC_HT_PRF_PDT|LLC.HT.PRF.PDT]]||[http://instruct.uwo.ca/anatomy/530/cblm.htm Cerebellum functional divisions (CTX -> PNN, abstract)]
+
| [[BrainCenterNC_AL_LPFC|Lateral Prefrontal Cortex]] (NC.AL.LPFC) || [[BrainRegionNPE_NC_BRA_PO|NPE.NC.BRA.PO]] -> [[BrainRegionLLC_HT_PRF_RTMG|LLC.HT.PRF.RTMG]]||[http://openagrosrl.com/www/page/292/ Motor neurons control (CTX -> PRF, abstract)]
 
|-
 
|-
| [[BrainCenterNC_PMC|Premotor Cortex]] (NC.PMC) || [[BrainRegionNMA_NC_PMC_AFEF|NMA.NC.PMC.AFEF]] -> [[BrainRegionLRC_HT_PRF_RPO|LRC.HT.PRF.RPO]]||[http://openagrosrl.com/www/page/292/ Motor neurons control (CTX -> PRF, abstract)]
+
| [[BrainCenterNC_PMC|Premotor Cortex]] (NC.PMC) || [[BrainRegionNPE_NC_PMC_AFEF|NPE.NC.PMC.AFEF]] -> [[BrainRegionLRC_HT_PRF_RPO|LRC.HT.PRF.RPO]]||[http://openagrosrl.com/www/page/292/ Motor neurons control (CTX -> PRF, abstract)]
 
|-
 
|-
| [[BrainRegionNMA_NC_MC|Motor Cortex]] (NMA.NC.MC) || [[BrainRegionNMA_NC_MC|NMA.NC.MC]] -> [[BrainRegionLLC_HT_PRF_PDT|LLC.HT.PRF.PDT]]||[http://instruct.uwo.ca/anatomy/530/cblm.htm Cerebellum functional divisions (CTX -> PNN, abstract)]
+
| [[BrainRegionNMA_NC_MC|Motor Cortex]] (NMA.NC.MC) || [[BrainRegionNMA_NC_MC|NMA.NC.MC]] -> [[BrainRegionLLC_HT_PRF_RTMG|LLC.HT.PRF.RTMG]]||[http://openagrosrl.com/www/page/292/ Motor neurons control (CTX -> PRF, abstract)]
 
|-
 
|-
| [[BrainCenterNMA_NC_SMC|Supplementary Motor Cortex]] (NMA.NC.SMC) || [[BrainRegionNMA_NC_SMC_F3|NMA.NC.SMC.F3]] -> [[BrainRegionLLC_HT_PRF_PDT|LLC.HT.PRF.PDT]]||[http://instruct.uwo.ca/anatomy/530/cblm.htm Cerebellum functional divisions (CTX -> PNN, abstract)]
+
| [[BrainCenterNMA_NC_SMC|Supplementary Motor Cortex]] (NMA.NC.SMC) || [[BrainRegionNMA_NC_SMC_F3|NMA.NC.SMC.F3]] -> [[BrainRegionLLC_HT_PRF_RTMG|LLC.HT.PRF.RTMG]]||[http://openagrosrl.com/www/page/292/ Motor neurons control (CTX -> PRF, abstract)]
 
|-
 
|-
 
| [[BrainCenterNSA_NC_IT|Inferotemporal Area]] (NSA.NC.IT) || [[BrainRegionNSA_NC_IT_TE|NSA.NC.IT.TE]] -> [[BrainRegionLRC_HT_PRF_RPO|LRC.HT.PRF.RPO]]||[http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/saccades.jpg Saccades and smooth movements (TEF -> DLPN, abstract)]
 
| [[BrainCenterNSA_NC_IT|Inferotemporal Area]] (NSA.NC.IT) || [[BrainRegionNSA_NC_IT_TE|NSA.NC.IT.TE]] -> [[BrainRegionLRC_HT_PRF_RPO|LRC.HT.PRF.RPO]]||[http://usvn.ahuman.org/svn/ahwiki/images/wiki/research/biomodel/saccades.jpg Saccades and smooth movements (TEF -> DLPN, abstract)]
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| [[BrainCenterFD_HT|Hypothalamus]] (FD.HT) || [[BrainRegionLPC_HT_PRF_PB|LPC.HT.PRF.PB]] -> [[BrainRegionLAC_FD_HT_DM|LAC.FD.HT.DM]]||[http://www.pnas.org/content/103/32/12150/F7.expansion.html Food-entrainable circadian oscillator (PBN -> DMH)]
 
| [[BrainCenterFD_HT|Hypothalamus]] (FD.HT) || [[BrainRegionLPC_HT_PRF_PB|LPC.HT.PRF.PB]] -> [[BrainRegionLAC_FD_HT_DM|LAC.FD.HT.DM]]||[http://www.pnas.org/content/103/32/12150/F7.expansion.html Food-entrainable circadian oscillator (PBN -> DMH)]
 
|-
 
|-
| [[BrainCenterFD_TH_SR|Sensory Thalamus]] (FD.TH.SR) || [[BrainRegionLPC_HT_PRF_PB|LPC.HT.PRF.PB]] -> [[BrainRegionNSA_FD_TH_VPI|NSA.FD.TH.VPI]]||(unknown reference)
+
| [[BrainCenterFD_TH_SR|Sensory Thalamus]] (FD.TH.SR) || [[BrainRegionLPC_HT_PRF_PB|LPC.HT.PRF.PB]] -> [[BrainRegionNCP_FD_TH_VPI|NCP.FD.TH.VPI]]||(unknown reference)
 
|-
 
|-
 
| [[BrainCenterFEC_FT_BG|Basal Ganglia]] (FEC.FT.BG) || [[BrainRegionLPC_HT_PRF_PB|LPC.HT.PRF.PB]] -> [[BrainRegionFEC_FT_ACC_SH|FEC.FT.ACC.SH]]||[http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (PBN -> NAc, abstract)]
 
| [[BrainCenterFEC_FT_BG|Basal Ganglia]] (FEC.FT.BG) || [[BrainRegionLPC_HT_PRF_PB|LPC.HT.PRF.PB]] -> [[BrainRegionFEC_FT_ACC_SH|FEC.FT.ACC.SH]]||[http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (PBN -> NAc, abstract)]
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| [[BrainCenterHT_TG|Pontine Tegmental Nuclei]] (HT.TG) || [[BrainRegionLRC_HT_PRF_RPO|LRC.HT.PRF.RPO]] -> [[BrainRegionFAM_HT_TG_NI|FAM.HT.TG.NI]]||(unknown reference)
 
| [[BrainCenterHT_TG|Pontine Tegmental Nuclei]] (HT.TG) || [[BrainRegionLRC_HT_PRF_RPO|LRC.HT.PRF.RPO]] -> [[BrainRegionFAM_HT_TG_NI|FAM.HT.TG.NI]]||(unknown reference)
 
|-
 
|-
| [[BrainCenterLLC_HT_CRC|Cerebellar Complex]] (LLC.HT.CRC) || [[BrainRegionLLC_HT_PRF_PDT|LLC.HT.PRF.PDT]] -> [[BrainRegionLLC_HT_CR_CC|LLC.HT.CR.CC]]||[http://instruct.uwo.ca/anatomy/530/cblm.htm Cerebellum functional divisions (PNN -> CRP)]
+
| [[BrainCenterLLC_HT_CRC|Cerebellar Complex]] (LLC.HT.CRC) || [[BrainRegionLLC_HT_PRF_RTMG|LLC.HT.PRF.RTMG]] -> [[BrainRegionLRC_HT_CR_FN|LRC.HT.CR.FN]]||(unknown reference)
 
|-
 
|-
 
| [[BrainRegionLPC_HT_ABD|Abducens Nucleus]] (LPC.HT.ABD) || [[BrainRegionLRC_HT_PRF_RPO|LRC.HT.PRF.RPO]] -> [[BrainRegionLPC_HT_ABD|LPC.HT.ABD]]||[http://www.neuroanatomy.wisc.edu/virtualbrain/BrainStem/13VNAN.html Vestibulo-ocular reflex (VOR) (PPRF -> Abducens, abstract)]
 
| [[BrainRegionLPC_HT_ABD|Abducens Nucleus]] (LPC.HT.ABD) || [[BrainRegionLRC_HT_PRF_RPO|LRC.HT.PRF.RPO]] -> [[BrainRegionLPC_HT_ABD|LPC.HT.ABD]]||[http://www.neuroanatomy.wisc.edu/virtualbrain/BrainStem/13VNAN.html Vestibulo-ocular reflex (VOR) (PPRF -> Abducens, abstract)]
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| [[BrainCenterNC_INS|Insular Cortex]] (NC.INS) || [[BrainRegionLPC_HT_PRF_PB|LPC.HT.PRF.PB]] -> [[BrainRegionNCP_NC_INS_PIC|NCP.NC.INS.PIC]]||[http://www.sciencedirect.com/science/article/pii/S0149763401000215 Gustatory sensory system of rat and macaque (PB -> Gud, abstract)]
 
| [[BrainCenterNC_INS|Insular Cortex]] (NC.INS) || [[BrainRegionLPC_HT_PRF_PB|LPC.HT.PRF.PB]] -> [[BrainRegionNCP_NC_INS_PIC|NCP.NC.INS.PIC]]||[http://www.sciencedirect.com/science/article/pii/S0149763401000215 Gustatory sensory system of rat and macaque (PB -> Gud, abstract)]
 
|-
 
|-
| [[BrainCenterSC_VH|Anterior/Ventral Horn]] (SC.VH) || [[BrainRegionLRC_HT_PRF_RPO|LRC.HT.PRF.RPO]] -> [[BrainRegionLPC_SC_VH_SAN|LPC.SC.VH.SAN]]||[http://openagrosrl.com/www/page/292/ Motor neurons control (PRF -> EGMN, abstract)]
+
| [[BrainCenterSC_VH|Anterior/Ventral Horn]] (SC.VH) || [[BrainRegionLRC_HT_PRF_RPO|LRC.HT.PRF.RPO]] -> [[BrainRegionLPC_SC_VH_SAN|LPC.SC.VH.SAN]]||[http://instruct.uwo.ca/anatomy/530/cblm.htm Cerebellum functional divisions (RF -> SCM, abstract)]
 
|}
 
|}

Revision as of 10:06, 10 July 2016

Pontine Reticular Formation

@@Home -> BiologicalLifeResearch -> BrainCenterHT_RF


This page covers biological details of component group Pontine Reticular Formation. Component group is part of aHuman target integrated biological model.

  • Top-down path to center: Hindbrain Metencephalon -> Pontine Reticular Formation (HT.RF) (see Mind Maps)
  • Function:

(generated)

Components

(generated)


Component items:

Connectivity

(generated)


Internal Regions Connections:

  • no connections

External Connections:

unavailable

External Inbound Center Connections:

Source Center Sample Link Reference
Central Extended Amygdala (FAM.FT.CEAM) FAM.FT.IPAC.MED -> LPC.HT.PRF.PB (unknown reference)
Hypothalamus (FD.HT) FMM.FD.MB.LMB -> LLC.HT.PRF.RTMG Mammillary Body (LMB -> RTG)
Basal Ganglia (FEC.FT.BG) FEC.FT.SNC.MED -> LRC.HT.PRF.PVR (unknown reference)
Myelencephalic Sensory Nuclei (HL.SN) LPC.HL.TGS.STR -> LLC.HT.PRF.RTMG Eye blink reflex and pupillary light reflex (SpinalTrigeminal -> RF, abstract)
Cerebellar Complex (LLC.HT.CRC) LRC.HT.CR.FG -> LRC.HT.PRF.CRF Cerebellum functional divisions (FG -> RF, abstract)
Vestibular Nuclei (LPC.HT.VBN) LPC.HT.IVBN -> LRC.HT.PRF.CRF Vestibulo-ocular reflex (VOR) (VestibularNuclei -> PPRF, abstract)
Reflexes Nuclei of Midbrain Mesencephalon (MM.REF) LRC.MM.SC.DEEP -> LLC.HT.PRF.RTMG Geniculate and Extyrageniculate Paths (SC -> RF, abstract)
Mesencephalic Reticular Formation (MM.RF) LRC.MM.SCNF -> LMC.HP.RP.PRN (unknown reference)
Anterior Cingulate Area (NC.ACG) NDM.NC.AL.VACG -> LLC.HT.PRF.RTMG Motor neurons control (CTX -> PRF, abstract)
Lateral Prefrontal Cortex (NC.AL.LPFC) NPE.NC.BRA.PO -> LLC.HT.PRF.RTMG Motor neurons control (CTX -> PRF, abstract)
Premotor Cortex (NC.PMC) NPE.NC.PMC.AFEF -> LRC.HT.PRF.RPO Motor neurons control (CTX -> PRF, abstract)
Motor Cortex (NMA.NC.MC) NMA.NC.MC -> LLC.HT.PRF.RTMG Motor neurons control (CTX -> PRF, abstract)
Supplementary Motor Cortex (NMA.NC.SMC) NMA.NC.SMC.F3 -> LLC.HT.PRF.RTMG Motor neurons control (CTX -> PRF, abstract)
Inferotemporal Area (NSA.NC.IT) NSA.NC.IT.TE -> LRC.HT.PRF.RPO Saccades and smooth movements (TEF -> DLPN, abstract)

External Outbound Center Connections:

Target Center Sample Link Reference
Amygdala (FAM.FT.AM) LPC.HT.PRF.PB -> FAM.FT.AM.CEL Amygdalar disruption of prefrontal cortex (PB -> AM, abstract)
Hypothalamus (FD.HT) LPC.HT.PRF.PB -> LAC.FD.HT.DM Food-entrainable circadian oscillator (PBN -> DMH)
Sensory Thalamus (FD.TH.SR) LPC.HT.PRF.PB -> NCP.FD.TH.VPI (unknown reference)
Basal Ganglia (FEC.FT.BG) LPC.HT.PRF.PB -> FEC.FT.ACC.SH Bowels control brain: gut hormones and obesity (PBN -> NAc, abstract)
Myelencephalic Motor Nuclei (HL.MN) LRC.HT.PRF.CRF -> LPC.HL.AMB Vocal Control (RF -> NucleusAmbiguus, abstract)
Myelencephalic Parasympathetic Nuclei (HL.PSN) LPC.HT.PRF.PB -> LAC.HL.VGN Physiology and pathophysiology of lower urinary tract (PBN -> DVM)
Metencephalic Motor Nuclei (HT.MN) LRC.HT.PRF.CRF -> LPC.HT.FCM Vocal Control (RF -> MotorVII, abstract)
Pontine Tegmental Nuclei (HT.TG) LRC.HT.PRF.RPO -> FAM.HT.TG.NI (unknown reference)
Cerebellar Complex (LLC.HT.CRC) LLC.HT.PRF.RTMG -> LRC.HT.CR.FN (unknown reference)
Abducens Nucleus (LPC.HT.ABD) LRC.HT.PRF.RPO -> LPC.HT.ABD Vestibulo-ocular reflex (VOR) (PPRF -> Abducens, abstract)
Vestibular Nuclei (LPC.HT.VBN) LRC.HT.PRF.RPO -> LPC.HT.IVBN (unknown reference)
Perhipheral Nuclei of Midbrain Mesencephalon (MM.PER) LRC.HT.PRF.RPO -> LPC.MM.OCN Global visual system (RF -> OPN, abstract)
Insular Cortex (NC.INS) LPC.HT.PRF.PB -> NCP.NC.INS.PIC Gustatory sensory system of rat and macaque (PB -> Gud, abstract)
Anterior/Ventral Horn (SC.VH) LRC.HT.PRF.RPO -> LPC.SC.VH.SAN Cerebellum functional divisions (RF -> SCM, abstract)