BrainAreaNMA

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Motor Aggregation Area

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Local Circuits

(generated)

ID Name Regions
FLM Flexor Motor NMA.FD.TH.VL, NMA.NC.MC
SEQ Complex Motor NMA.FD.TH.MDL, NMA.NC.PMC.AFEF, NMA.NC.PMC.CFEF, NMA.NC.SMC.F3, NMA.NC.SMC.F6, NMA.NC.SMC.SEF
XTM Extensor Motor NMA.FD.TH.VA, NMA.NC.PMC.F2, NMA.NC.PMC.F4, NMA.NC.PMC.F5, NMA.NC.PMC.F7

Flexor Motor

unavailable

Component ID Component Name Type Service Function Comments
NMA.FD.TH.VL Ventral Lateral Nucleus nucleus NMU Relay BSA.CR to MCA.MC Executive motor
NMA.NC.MC Motor Cortex cortex, BA 04 NMU Execution of required voluntary movements F1; Encode individual movements

Internal Region Connections:

Source Region Target Region Type Reference
NMA.FD.TH.VL NMA.NC.MC nucleus-neocortex [relationships (VL -> pVL)]

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NMA NMA.NC.MC NMA.NC.PMC.F2 Dorsal Caudal Premotor Cortex neocortex-neocortex [Cortex (PFC) in motor behavior (PMC -> MC, abstract)]
NMA.NC.PMC.F5 Ventral Rostral Premotor Cortex neocortex-neocortex [Control of Grasping (F5 -> F1)]
NSA NMA.NC.MC NSA.NC.PG.PV Parietal Ventral Cortex neocortex-neocortex [visual system (ParietalCortex -> FrontalCortex, abstract)]
NSA.NC.PG.S2 Secondary Somatosensory Cortex neocortex-neocortex [visual system (ParietalCortex -> FrontalCortex, abstract)]
Subcortical
FEC NMA.FD.TH.VL FEC.FT.GPI.LT Globus Pallidus Internal Lateral nucleus-nucleus-gaba [relationships (s2VL -> VL, abstract)]
LLC NMA.FD.TH.VL LLC.HP.CR.DN Dentate Nucleus nucleus-nucleus [relationships (s1VL -> VL, abstract)]

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NMA NMA.FD.TH.VL NMA.NC.PMC.F5 Ventral Rostral Premotor Cortex nucleus-neocortex [Ganglia Activity (VLo -> PMC, abstract)]
NMA.NC.SMC.F6 Pre-Supplementary Motor Area nucleus-neocortex [Ganglia Activity (VLo -> SMC, abstract)]
Subcortical
FEC NMA.NC.MC FEC.FD.STN.LT Subthalamic Nucleus Lateral neocortex-nucleus (unknown reference)
FEC.FT.PU.LT Dorsal Putamen Lateral neocortex-nucleus (unknown reference)
LLC NMA.NC.MC LLC.HP.PN.PBB Pontobulbar Body neocortex-nucleus [Cortex (PFC) in motor behavior (MC -> PN, abstract)]
LLC.HP.PRF.PDT Pontine Reticulotegmental Nucleus neocortex-nucleus [visual system (FrontalCortex -> RF, abstract)]
LPC NMA.NC.MC LPC.HM.AMB Ambiguus Nucleus neocortex-nucleus (unknown reference)
LPC.SC.VH.ONF Onuf's Nucleus neocortex-nucleus (unknown reference)
LPC.SC.VH.PL Posterolateral Nucleus neocortex-nucleus (unknown reference)
LPC.SC.VH.PM Posteromedial Nucleus neocortex-nucleus (unknown reference)
LPC.SC.VH.RPL Retroposterolateral Nucleus neocortex-nucleus (unknown reference)
LRC NMA.NC.MC LRC.HP.PRF.CRF Caudal Pontine Reticular Nucleus neocortex-nucleus [visual system (FrontalCortex -> RF, abstract)]

Complex Motor

unavailable

Component ID Component Name Type Service Function Comments
NMA.FD.TH.MDL Lateral Mediodorsal Nucleus of Thalamus nucleus NPU relay tegmentum to dorsal cingulate cortex Relay Superior Colliculus, TH-LD, LDTG, IPD to
ACCdl
NMA.NC.PMC.AFEF Anterior Frontal Eye Field cortex, BA 08 NMU Head and eye movements toward auditory stimuli longer saccades, dorsomedial - 8A (8Ac, 8Am), but
not 8Ar; 8Ac - saccades
NMA.NC.PMC.CFEF Caudal Frontal Eye Field cortex, BA 08 NMU Head and eye movements toward visual stimuli shorter saccades
NMA.NC.SMC.F3 Supplementary Motor Area cortex, BA 06 NMU Movement execution; Numerical and verbal mental-operation tasks from TH/VLo from from putamen; F1/F2/F4/24d -
strong; F6/F7/F5/24c - modest; no input from the
prefrontal lobe
NMA.NC.SMC.F6 Pre-Supplementary Motor Area cortex, BA 06 NMU High level motor functions; Numerical and verbal mental-operation tasks from TH/VLpc, MD from caudate, CR; F5/24c/46; no
connections with F1
NMA.NC.SMC.SEF Supplementary Eye Field cortex, BA 06 NMU high level aspects of saccade control Complex spatial transformations, learned
transformations, and executive cognitive functions;
dorsorostral of F7

Internal Region Connections:

Source Region Target Region Type Reference
NMA.FD.TH.MDL NMA.NC.PMC.AFEF nucleus-neocortex [decision-making (Thalamus -> FEF, abstract)]
NMA.NC.PMC.CFEF NMA.NC.PMC.AFEF neocortex-neocortex (unknown reference)
NMA.NC.SMC.SEF NMA.NC.PMC.AFEF neocortex-neocortex [of eye movement control (SEF -> FEF, abstract)]

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NDM NMA.NC.PMC.AFEF NDM.NC.AL.DLPFCL Lateral Mid-Dorsolateral Prefrontal Cortex neocortex-neocortex [Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)]
NMA.NC.SMC.SEF NDM.NC.AL.DLPFCR Rostral Mid-Dorsolateral Prefrontal Cortex neocortex-neocortex [Visual Cortex Paths (LPC -> pre-SMA, abstract)]
NMA NMA.NC.SMC.F3 NMA.FD.TH.VA Ventral Anterior Nucleus nucleus-neocortex [relationships (VA -> pVA, abstract)]
NMA.NC.PMC.F4 Ventral Caudal Premotor Cortex neocortex-neocortex (unknown reference)
NMA.NC.SMC.F6 NMA.FD.TH.VL Ventral Lateral Nucleus nucleus-neocortex [Ganglia Activity (VLo -> SMC, abstract)]
NPE NMA.NC.PMC.AFEF NPE.NC.BRA.PO Broca's Area Pars Opercularis neocortex-neocortex [Auditory System (IFC44 -> PMC8, abstract)]
NMA.NC.PMC.CFEF NPE.NC.IPS.LIP Lateral Intraparietal Sulcus neocortex-neocortex [of eye movement control (PEF -> FEF, abstract)]
NMA.NC.SMC.SEF NPE.NC.SPL.PG Caudal Precuneus neocortex-neocortex [Planning (PPC -> SMC, abstract)]
NSA NMA.NC.PMC.CFEF NSA.NC.IT.TE Inferotemporal Cortex neocortex-neocortex [and smooth movements (TEF -> FEF, abstract)]
Subcortical
FEC NMA.FD.TH.MDL FEC.FT.SNR.MED Substantia Nigra Pars Reticulata Medial nucleus-nucleus-gaba [Vision (BG -> Thalamus, abstract)]

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NDM NMA.FD.TH.MDL NDM.NC.AL.DACG Dorsal Anterior Cingulate Area nucleus-neocortex [Vision (Thalamus -> FrontalCortex, abstract)]
NMA NMA.NC.PMC.AFEF NMA.NC.PMC.F7 Dorsal Rostral Premotor Cortex neocortex-neocortex (unknown reference)
NMA.NC.PMC.CFEF NMA.NC.PMC.F5 Ventral Rostral Premotor Cortex neocortex-neocortex (unknown reference)
NMA.NC.SMC.F3 NMA.NC.PMC.F2 Dorsal Caudal Premotor Cortex neocortex-neocortex [Visual Cortex Paths (pre-SMA -> dPM, abstract)]
NMA.NC.PMC.F5 Ventral Rostral Premotor Cortex neocortex-neocortex [Visual Cortex Paths (pre-SMA -> vPM, abstract)]
NMA.NC.SMC.F6 NMA.NC.PMC.F5 Ventral Rostral Premotor Cortex neocortex-neocortex [Control of Grasping (F6 -> F5)]
Subcortical
FEC NMA.NC.PMC.AFEF FEC.FT.CN.BD Caudate Nucleus Body neocortex-nucleus [visual system (FrontalCortex -> BGA, abstract)]
NMA.NC.SMC.F3 FEC.FT.PU.MED Dorsal Putamen Medial neocortex-nucleus (unknown reference)
NMA.NC.SMC.F6 FEC.FD.STN.MED Subthalamic Nucleus Medial neocortex-nucleus (unknown reference)
LLC NMA.NC.SMC.F3 LLC.HP.PRF.PDT Pontine Reticulotegmental Nucleus neocortex-nucleus [Control (M2 -> RF, abstract)]
LRC NMA.NC.PMC.AFEF LRC.HP.PRF.GCR Gigantocellular Reticular Nucleus neocortex-nucleus (unknown reference)
LRC.HP.PRF.RPO Oral Pontine Reticular Nucleus neocortex-nucleus [visual system (FrontalCortex -> RF, abstract)]
LRC.MM.CJ Cajal Nucleus neocortex-nucleus [of eye movement control (FEF -> riMLF, abstract)]
LRC.MM.DSCH Darkschewitsch Nucleus neocortex-nucleus (unknown reference)
LRC.MM.SC.INT Intermediate Superior Colliculus neocortex-nucleus [of eye movement control (FEF -> SC, abstract)]
NMA.NC.SMC.F3 LRC.HP.PRF.CRF Caudal Pontine Reticular Nucleus neocortex-nucleus [Control (M2 -> RF, abstract)]
LRC.HP.PRF.GCR Gigantocellular Reticular Nucleus neocortex-nucleus (unknown reference)
NMA.NC.SMC.SEF LRC.MM.RP.RIP Raphe Interpositus Nucleus neocortex-nucleus [saccades and smooth pursuit movements (FEFSEF -> RIP, abstract)]

Extensor Motor

unavailable

Component ID Component Name Type Service Function Comments
NMA.FD.TH.VA Ventral Anterior Nucleus nucleus NMU Relay BGA.SN, BGA.GPI, FCA.OMPFC, FCA.CG to MCA.PMC, MCA.SMC Cognitive motor
NMA.NC.PMC.F2 Dorsal Caudal Premotor Cortex cortex, BA 06 NMU Guiding reaching 6DC; Active during preparation for reach and also
during reach itself; leg and arm; transform sensory
information into motor representation; preparation
and execution of motor acts
NMA.NC.PMC.F4 Ventral Caudal Premotor Cortex cortex, BA 06 NMU Sensory guidance of movement 6VC; Neurons are especially sensitive to objects in
space immediately surrounding body; move head, face
and arm
NMA.NC.PMC.F5 Ventral Rostral Premotor Cortex cortex, BA 06 NMU Shaping hand during grasping 6VR; Mirror neurons - both sensory and motor; arm;
F5c=convexity - F1/F4/F2VR/F6/F3/24d/24c,
F5p=posterior - F3/F4/F1/24c/24a, F5a=anterior -
F4/F6/24c/24d/24a/46v/12r/12l
NMA.NC.PMC.F7 Dorsal Rostral Premotor Cortex cortex, BA 06 NMU Associate arbitrary sensory stimuli with specific eye movements 6DR; Can evoke eye movements; strong afferents from
DLPFC; convey inputs to caudal concerning
motivation, long term plans, memory of past
actions; integrates sensory and internally driven
inputs for planning of goal-directed actions

Internal Region Connections:

Source Region Target Region Type Reference
NMA.FD.TH.VA NMA.NC.PMC.F2 nucleus-neocortex [Cortex (PFC) in motor behavior (TH -> PMC, abstract)]
NMA.NC.PMC.F4 NMA.NC.PMC.F2 neocortex-neocortex (unknown reference)
NMA.NC.PMC.F5 NMA.NC.PMC.F2 neocortex-neocortex (unknown reference)
NMA.NC.PMC.F7 NMA.NC.PMC.F2 neocortex-neocortex (unknown reference)

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NDM NMA.FD.TH.VA NDM.NC.AL.DLPFCL Lateral Mid-Dorsolateral Prefrontal Cortex neocortex-nucleus [Cortex (PFC) in motor behavior (LPFC -> TH, abstract)]
NMA.NC.PMC.F2 NDM.NC.AL.VACG Ventral Anterior Cingulate Area neocortex-neocortex (unknown reference)
NMA.NC.PMC.F5 NDM.NC.AL.DLPFCL Lateral Mid-Dorsolateral Prefrontal Cortex neocortex-neocortex [Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)]
NMA.NC.PMC.F7 NDM.NC.AL.DACG Dorsal Anterior Cingulate Area neocortex-neocortex (unknown reference)
NDM.NC.AL.DLPFCR Rostral Mid-Dorsolateral Prefrontal Cortex neocortex-neocortex [Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)]
NMA NMA.NC.PMC.F2 NMA.NC.SMC.F3 Supplementary Motor Area neocortex-neocortex [Visual Cortex Paths (pre-SMA -> dPM, abstract)]
NMA.NC.PMC.F5 NMA.FD.TH.VL Ventral Lateral Nucleus nucleus-neocortex [Ganglia Activity (VLo -> PMC, abstract)]
NMA.NC.PMC.CFEF Caudal Frontal Eye Field neocortex-neocortex (unknown reference)
NMA.NC.SMC.F3 Supplementary Motor Area neocortex-neocortex [Visual Cortex Paths (pre-SMA -> vPM, abstract)]
NMA.NC.SMC.F6 Pre-Supplementary Motor Area neocortex-neocortex [Control of Grasping (F6 -> F5)]
NMA.NC.PMC.F7 NMA.NC.PMC.AFEF Anterior Frontal Eye Field neocortex-neocortex (unknown reference)
NPE NMA.NC.PMC.F2 NPE.NC.IPL.SMW Supramarginal Wernike Cortex neocortex-neocortex [Auditory Processing (PPC -> DLPFC, abstract)]
NPE.NC.SPL.PF Rostral Precuneus neocortex-neocortex [Visual Cortex Paths (SPL -> dPM, abstract)]
NPE.NC.SPL.PG Caudal Precuneus neocortex-neocortex [Visual Cortex Paths (SPL -> dPM, abstract)]
NPE.NC.SPL.SA Somatosensory Association Cortex neocortex-neocortex [Visual Cortex Paths (SPL -> dPM, abstract)]
NMA.NC.PMC.F4 NPE.NC.IPL.MST Medial Superior Temporal Area neocortex-neocortex [Visual Cortex Paths (IPL -> vPM, abstract)]
NPE.NC.IPL.SMW Supramarginal Wernike Cortex neocortex-neocortex [Visual Cortex Paths (IPL -> vPM, abstract)]
NMA.NC.PMC.F7 NPE.NC.IPS.LIP Lateral Intraparietal Sulcus neocortex-neocortex [visual system (ParietalCortex -> FrontalCortex, abstract)]
NSA NMA.NC.PMC.F2 NSA.NC.PG.S1 Primary Somatosensory Cortex neocortex-neocortex [visual system (ParietalCortex -> FrontalCortex, abstract)]
NMA.NC.PMC.F4 NSA.NC.IPS.AIP Anterior Intraparietal Sulcus neocortex-neocortex [Control of Grasping (AIP -> F4)]
NSA.NC.IPS.VIP Ventral Intraparietal Sulcus neocortex-neocortex [Control of Grasping (VIP -> F4)]
NSA.NC.STG.A3 Wernicke's area A3 neocortex-neocortex [Auditory Processing (ST -> VLPFC, abstract)]
NSA.NC.STG.A4 Wernicke's area A4 neocortex-neocortex [Regions (pSTC -> PMC, abstract)]
NMA.NC.PMC.F5 NSA.NC.IPS.AIP Anterior Intraparietal Sulcus neocortex-neocortex [Control of Grasping (AIP -> F5)]
NSA.NC.PG.S1 Primary Somatosensory Cortex neocortex-neocortex [Control of Grasping (S2 -> F5)]
NMA.NC.PMC.F7 NSA.NC.TTG.A1 Primary Auditory Cortex neocortex-neocortex [Auditory Processing (A1 -> DLPFC, abstract)]
Subcortical
FEC NMA.FD.TH.VA FEC.FT.GPI.DS Globus Pallidus Internal Dorsal nucleus-nucleus-gaba [relationships (sVA -> VA, abstract)]
FEC.FT.GPI.MED Globus Pallidus Internal Medial nucleus-nucleus-gaba [relationships (sVA -> VA, abstract)]
FEC.FT.SNR.DL Substantia Nigra Pars Reticulata Dorsolateral nucleus-nucleus-gaba [relationships (sVA -> VA, abstract)]
LRC NMA.FD.TH.VA LRC.MM.SC.INT Intermediate Superior Colliculus nucleus-nucleus [Vision (SCi -> Thalamus, abstract)]

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NDM NMA.NC.PMC.F4 NDM.NC.AL.DLPFCL Lateral Mid-Dorsolateral Prefrontal Cortex neocortex-neocortex [Connectivity (MA -> PFC, abstract)]
NMA NMA.FD.TH.VA NMA.NC.SMC.F3 Supplementary Motor Area nucleus-neocortex [relationships (VA -> pVA, abstract)]
NMA.NC.PMC.F2 NMA.NC.MC Motor Cortex neocortex-neocortex [Cortex (PFC) in motor behavior (PMC -> MC, abstract)]
NMA.NC.PMC.F4 NMA.NC.SMC.F3 Supplementary Motor Area neocortex-neocortex (unknown reference)
NMA.NC.PMC.F5 NMA.NC.MC Motor Cortex neocortex-neocortex [Control of Grasping (F5 -> F1)]
NPE NMA.NC.PMC.F7 NPE.NC.SPL.SA Somatosensory Association Cortex neocortex-neocortex [Connectivity (MA -> SA, abstract)]
Subcortical
FEC NMA.NC.PMC.F2 FEC.FT.PU.MED Dorsal Putamen Medial neocortex-nucleus (unknown reference)
NMA.NC.PMC.F5 FEC.FT.PU.MED Dorsal Putamen Medial neocortex-nucleus (unknown reference)

Thirdparty Circuits

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References

(generated)