Motor Aggregation Area

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Local Circuits

(generated)

|| ID || Name || Regions || || FLM || Flexor Motor || NMA.FD.TH.VL, NMA.NC.MC || || SEQ || Complex Motor || NMA.FD.TH.MDL, NMA.NC.PMC.AFEF, NMA.NC.PMC.CFEF, NMA.NC.SMC.F3, NMA.NC.SMC.F6, NMA.NC.SMC.SEF || || XTM || Extensor Motor || NMA.FD.TH.VA, NMA.NC.PMC.F2, NMA.NC.PMC.F4, NMA.NC.PMC.F5, NMA.NC.PMC.F7 ||

Flexor Motor

unavailable

|| Component ID || Component Name || Type || Service || Function || Comments || || NMA.FD.TH.VL || Ventral Lateral Nucleus || nucleus || NMU || Relay BSA.CR to MCA.MC || Executive motor || || NMA.NC.MC || Motor Cortex || cortex, BA 04 || NMU || Execution of required voluntary movements || F1; Encode individual movements ||

Internal Region Connections:*

|| Source Region || Target Region || Type || Reference || || NMA.FD.TH.VL || NMA.NC.MC || nucleus-neocortex || [relationships (VL -> pVL)] ||

External Inbound Region Connections:*

|| Source Area || Local Region || Source Region || Source Name || Type || Reference || || Cortical || || || || || || || NMA || NMA.NC.MC || NMA.NC.PMC.F2 || Dorsal Caudal Premotor Cortex || neocortex-neocortex || [Cortex (PFC) in motor behavior (PMC -> MC, abstract)] || || || || NMA.NC.PMC.F5 || Ventral Rostral Premotor Cortex || neocortex-neocortex || [Control of Grasping (F5 -> F1)] || || NSA || NMA.NC.MC || NSA.NC.PG.PV || Parietal Ventral Cortex || neocortex-neocortex || [visual system (ParietalCortex -> FrontalCortex, abstract)] || || || || NSA.NC.PG.S2 || Secondary Somatosensory Cortex || neocortex-neocortex || [visual system (ParietalCortex -> FrontalCortex, abstract)] || || Subcortical || || || || || || || FEC || NMA.FD.TH.VL || FEC.FT.GPI.LT || Globus Pallidus Internal Lateral || nucleus-nucleus-gaba || [relationships (s2VL -> VL, abstract)] || || LLC || NMA.FD.TH.VL || LLC.HP.CR.DN || Dentate Nucleus || nucleus-nucleus || [relationships (s1VL -> VL, abstract)] ||

External Outbound Region Connections:*

|| Target Area || Local Region || Target Region || Target Name || Type || Reference || || Cortical || || || || || || || NMA || NMA.FD.TH.VL || NMA.NC.PMC.F5 || Ventral Rostral Premotor Cortex || nucleus-neocortex || [Ganglia Activity (VLo -> PMC, abstract)] || || || || NMA.NC.SMC.F6 || Pre-Supplementary Motor Area || nucleus-neocortex || [Ganglia Activity (VLo -> SMC, abstract)] || || Subcortical || || || || || || || FEC || NMA.NC.MC || FEC.FD.STN.LT || Subthalamic Nucleus Lateral || neocortex-nucleus || (unknown reference) || || || || FEC.FT.PU.LT || Dorsal Putamen Lateral || neocortex-nucleus || (unknown reference) || || LLC || NMA.NC.MC || LLC.HP.PN.PBB || Pontobulbar Body || neocortex-nucleus || [Cortex (PFC) in motor behavior (MC -> PN, abstract)] || || || || LLC.HP.PRF.PDT || Pontine Reticulotegmental Nucleus || neocortex-nucleus || [visual system (FrontalCortex -> RF, abstract)] || || LPC || NMA.NC.MC || LPC.HM.AMB || Ambiguus Nucleus || neocortex-nucleus || (unknown reference) || || || || LPC.SC.VH.ONF || Onuf's Nucleus || neocortex-nucleus || (unknown reference) || || || || LPC.SC.VH.PL || Posterolateral Nucleus || neocortex-nucleus || (unknown reference) || || || || LPC.SC.VH.PM || Posteromedial Nucleus || neocortex-nucleus || (unknown reference) || || || || LPC.SC.VH.RPL || Retroposterolateral Nucleus || neocortex-nucleus || (unknown reference) || || LRC || NMA.NC.MC || LRC.HP.PRF.CRF || Caudal Pontine Reticular Nucleus || neocortex-nucleus || [visual system (FrontalCortex -> RF, abstract)] ||

Complex Motor

unavailable

|| Component ID || Component Name || Type || Service || Function || Comments || || NMA.FD.TH.MDL || Lateral Mediodorsal Nucleus of Thalamus || nucleus || NPU || relay tegmentum to dorsal cingulate cortex || Relay Superior Colliculus, TH-LD, LDTG, IPD to
ACCdl || || NMA.NC.PMC.AFEF || Anterior Frontal Eye Field || cortex, BA 08 || NMU || Head and eye movements toward auditory stimuli || longer saccades, dorsomedial - 8A (8Ac, 8Am), but
not 8Ar; 8Ac - saccades || || NMA.NC.PMC.CFEF || Caudal Frontal Eye Field || cortex, BA 08 || NMU || Head and eye movements toward visual stimuli || shorter saccades || || NMA.NC.SMC.F3 || Supplementary Motor Area || cortex, BA 06 || NMU || Movement execution; Numerical and verbal mental-operation tasks || from TH/VLo from from putamen; F1/F2/F4/24d -
strong; F6/F7/F5/24c - modest; no input from the
prefrontal lobe || || NMA.NC.SMC.F6 || Pre-Supplementary Motor Area || cortex, BA 06 || NMU || High level motor functions; Numerical and verbal mental-operation tasks || from TH/VLpc, MD from caudate, CR; F5/24c/46; no
connections with F1 || || NMA.NC.SMC.SEF || Supplementary Eye Field || cortex, BA 06 || NMU || high level aspects of saccade control || Complex spatial transformations, learned
transformations, and executive cognitive functions;
dorsorostral of F7 ||

Internal Region Connections:*

|| Source Region || Target Region || Type || Reference || || NMA.FD.TH.MDL || NMA.NC.PMC.AFEF || nucleus-neocortex || [decision-making (Thalamus -> FEF, abstract)] || || NMA.NC.PMC.CFEF || NMA.NC.PMC.AFEF || neocortex-neocortex || (unknown reference) || || NMA.NC.SMC.SEF || NMA.NC.PMC.AFEF || neocortex-neocortex || [of eye movement control (SEF -> FEF, abstract)] ||

External Inbound Region Connections:*

|| Source Area || Local Region || Source Region || Source Name || Type || Reference || || Cortical || || || || || || || NDM || NMA.NC.PMC.AFEF || NDM.NC.AL.DLPFCL || Lateral Mid-Dorsolateral Prefrontal Cortex || neocortex-neocortex || [Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)] || || || NMA.NC.SMC.SEF || NDM.NC.AL.DLPFCR || Rostral Mid-Dorsolateral Prefrontal Cortex || neocortex-neocortex || [Visual Cortex Paths (LPC -> pre-SMA, abstract)] || || NMA || NMA.NC.SMC.F3 || NMA.FD.TH.VA || Ventral Anterior Nucleus || nucleus-neocortex || [relationships (VA -> pVA, abstract)] || || || || NMA.NC.PMC.F4 || Ventral Caudal Premotor Cortex || neocortex-neocortex || (unknown reference) || || || NMA.NC.SMC.F6 || NMA.FD.TH.VL || Ventral Lateral Nucleus || nucleus-neocortex || [Ganglia Activity (VLo -> SMC, abstract)] || || NPE || NMA.NC.PMC.AFEF || NPE.NC.BRA.PO || Broca's Area Pars Opercularis || neocortex-neocortex || [Auditory System (IFC44 -> PMC8, abstract)] || || || NMA.NC.PMC.CFEF || NPE.NC.IPS.LIP || Lateral Intraparietal Sulcus || neocortex-neocortex || [of eye movement control (PEF -> FEF, abstract)] || || || NMA.NC.SMC.SEF || NPE.NC.SPL.PG || Caudal Precuneus || neocortex-neocortex || [Planning (PPC -> SMC, abstract)] || || NSA || NMA.NC.PMC.CFEF || NSA.NC.IT.TE || Inferotemporal Cortex || neocortex-neocortex || [and smooth movements (TEF -> FEF, abstract)] || || Subcortical || || || || || || || FEC || NMA.FD.TH.MDL || FEC.FT.SNR.MED || Substantia Nigra Pars Reticulata Medial || nucleus-nucleus-gaba || [Vision (BG -> Thalamus, abstract)] ||

External Outbound Region Connections:*

|| Target Area || Local Region || Target Region || Target Name || Type || Reference || || Cortical || || || || || || || NDM || NMA.FD.TH.MDL || NDM.NC.AL.DACG || Dorsal Anterior Cingulate Area || nucleus-neocortex || [Vision (Thalamus -> FrontalCortex, abstract)] || || NMA || NMA.NC.PMC.AFEF || NMA.NC.PMC.F7 || Dorsal Rostral Premotor Cortex || neocortex-neocortex || (unknown reference) || || || NMA.NC.PMC.CFEF || NMA.NC.PMC.F5 || Ventral Rostral Premotor Cortex || neocortex-neocortex || (unknown reference) || || || NMA.NC.SMC.F3 || NMA.NC.PMC.F2 || Dorsal Caudal Premotor Cortex || neocortex-neocortex || [Visual Cortex Paths (pre-SMA -> dPM, abstract)] || || || || NMA.NC.PMC.F5 || Ventral Rostral Premotor Cortex || neocortex-neocortex || [Visual Cortex Paths (pre-SMA -> vPM, abstract)] || || || NMA.NC.SMC.F6 || NMA.NC.PMC.F5 || Ventral Rostral Premotor Cortex || neocortex-neocortex || [Control of Grasping (F6 -> F5)] || || Subcortical || || || || || || || FEC || NMA.NC.PMC.AFEF || FEC.FT.CN.BD || Caudate Nucleus Body || neocortex-nucleus || [visual system (FrontalCortex -> BGA, abstract)] || || || NMA.NC.SMC.F3 || FEC.FT.PU.MED || Dorsal Putamen Medial || neocortex-nucleus || (unknown reference) || || || NMA.NC.SMC.F6 || FEC.FD.STN.MED || Subthalamic Nucleus Medial || neocortex-nucleus || (unknown reference) || || LLC || NMA.NC.SMC.F3 || LLC.HP.PRF.PDT || Pontine Reticulotegmental Nucleus || neocortex-nucleus || [Control (M2 -> RF, abstract)] || || LRC || NMA.NC.PMC.AFEF || LRC.HP.PRF.GCR || Gigantocellular Reticular Nucleus || neocortex-nucleus || (unknown reference) || || || || LRC.HP.PRF.RPO || Oral Pontine Reticular Nucleus || neocortex-nucleus || [visual system (FrontalCortex -> RF, abstract)] || || || || LRC.MM.CJ || Cajal Nucleus || neocortex-nucleus || [of eye movement control (FEF -> riMLF, abstract)] || || || || LRC.MM.DSCH || Darkschewitsch Nucleus || neocortex-nucleus || (unknown reference) || || || || LRC.MM.SC.INT || Intermediate Superior Colliculus || neocortex-nucleus || [of eye movement control (FEF -> SC, abstract)] || || || NMA.NC.SMC.F3 || LRC.HP.PRF.CRF || Caudal Pontine Reticular Nucleus || neocortex-nucleus || [Control (M2 -> RF, abstract)] || || || || LRC.HP.PRF.GCR || Gigantocellular Reticular Nucleus || neocortex-nucleus || (unknown reference) || || || NMA.NC.SMC.SEF || LRC.MM.RP.RIP || Raphe Interpositus Nucleus || neocortex-nucleus || [saccades and smooth pursuit movements (FEFSEF -> RIP, abstract)] ||

Extensor Motor

unavailable

|| Component ID || Component Name || Type || Service || Function || Comments || || NMA.FD.TH.VA || Ventral Anterior Nucleus || nucleus || NMU || Relay BGA.SN, BGA.GPI, FCA.OMPFC, FCA.CG to MCA.PMC, MCA.SMC || Cognitive motor || || NMA.NC.PMC.F2 || Dorsal Caudal Premotor Cortex || cortex, BA 06 || NMU || Guiding reaching || 6DC; Active during preparation for reach and also
during reach itself; leg and arm; transform sensory
information into motor representation; preparation
and execution of motor acts || || NMA.NC.PMC.F4 || Ventral Caudal Premotor Cortex || cortex, BA 06 || NMU || Sensory guidance of movement || 6VC; Neurons are especially sensitive to objects in
space immediately surrounding body; move head, face
and arm || || NMA.NC.PMC.F5 || Ventral Rostral Premotor Cortex || cortex, BA 06 || NMU || Shaping hand during grasping || 6VR; Mirror neurons - both sensory and motor; arm;
F5c=convexity - F1/F4/F2VR/F6/F3/24d/24c,
F5p=posterior - F3/F4/F1/24c/24a, F5a=anterior -
F4/F6/24c/24d/24a/46v/12r/12l || || NMA.NC.PMC.F7 || Dorsal Rostral Premotor Cortex || cortex, BA 06 || NMU || Associate arbitrary sensory stimuli with specific eye movements || 6DR; Can evoke eye movements; strong afferents from
DLPFC; convey inputs to caudal concerning
motivation, long term plans, memory of past
actions; integrates sensory and internally driven
inputs for planning of goal-directed actions ||

Internal Region Connections:*

|| Source Region || Target Region || Type || Reference || || NMA.FD.TH.VA || NMA.NC.PMC.F2 || nucleus-neocortex || [Cortex (PFC) in motor behavior (TH -> PMC, abstract)] || || NMA.NC.PMC.F4 || NMA.NC.PMC.F2 || neocortex-neocortex || (unknown reference) || || NMA.NC.PMC.F5 || NMA.NC.PMC.F2 || neocortex-neocortex || (unknown reference) || || NMA.NC.PMC.F7 || NMA.NC.PMC.F2 || neocortex-neocortex || (unknown reference) ||

External Inbound Region Connections:*

|| Source Area || Local Region || Source Region || Source Name || Type || Reference || || Cortical || || || || || || || NDM || NMA.FD.TH.VA || NDM.NC.AL.DLPFCL || Lateral Mid-Dorsolateral Prefrontal Cortex || neocortex-nucleus || [Cortex (PFC) in motor behavior (LPFC -> TH, abstract)] || || || NMA.NC.PMC.F2 || NDM.NC.AL.VACG || Ventral Anterior Cingulate Area || neocortex-neocortex || (unknown reference) || || || NMA.NC.PMC.F5 || NDM.NC.AL.DLPFCL || Lateral Mid-Dorsolateral Prefrontal Cortex || neocortex-neocortex || [Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)] || || || NMA.NC.PMC.F7 || NDM.NC.AL.DACG || Dorsal Anterior Cingulate Area || neocortex-neocortex || (unknown reference) || || || || NDM.NC.AL.DLPFCR || Rostral Mid-Dorsolateral Prefrontal Cortex || neocortex-neocortex || [Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)] || || NMA || NMA.NC.PMC.F2 || NMA.NC.SMC.F3 || Supplementary Motor Area || neocortex-neocortex || [Visual Cortex Paths (pre-SMA -> dPM, abstract)] || || || NMA.NC.PMC.F5 || NMA.FD.TH.VL || Ventral Lateral Nucleus || nucleus-neocortex || [Ganglia Activity (VLo -> PMC, abstract)] || || || || NMA.NC.PMC.CFEF || Caudal Frontal Eye Field || neocortex-neocortex || (unknown reference) || || || || NMA.NC.SMC.F3 || Supplementary Motor Area || neocortex-neocortex || [Visual Cortex Paths (pre-SMA -> vPM, abstract)] || || || || NMA.NC.SMC.F6 || Pre-Supplementary Motor Area || neocortex-neocortex || [Control of Grasping (F6 -> F5)] || || || NMA.NC.PMC.F7 || NMA.NC.PMC.AFEF || Anterior Frontal Eye Field || neocortex-neocortex || (unknown reference) || || NPE || NMA.NC.PMC.F2 || NPE.NC.IPL.SMW || Supramarginal Wernike Cortex || neocortex-neocortex || [Auditory Processing (PPC -> DLPFC, abstract)] || || || || NPE.NC.SPL.PF || Rostral Precuneus || neocortex-neocortex || [Visual Cortex Paths (SPL -> dPM, abstract)] || || || || NPE.NC.SPL.PG || Caudal Precuneus || neocortex-neocortex || [Visual Cortex Paths (SPL -> dPM, abstract)] || || || || NPE.NC.SPL.SA || Somatosensory Association Cortex || neocortex-neocortex || [Visual Cortex Paths (SPL -> dPM, abstract)] || || || NMA.NC.PMC.F4 || NPE.NC.IPL.MST || Medial Superior Temporal Area || neocortex-neocortex || [Visual Cortex Paths (IPL -> vPM, abstract)] || || || || NPE.NC.IPL.SMW || Supramarginal Wernike Cortex || neocortex-neocortex || [Visual Cortex Paths (IPL -> vPM, abstract)] || || || NMA.NC.PMC.F7 || NPE.NC.IPS.LIP || Lateral Intraparietal Sulcus || neocortex-neocortex || [visual system (ParietalCortex -> FrontalCortex, abstract)] || || NSA || NMA.NC.PMC.F2 || NSA.NC.PG.S1 || Primary Somatosensory Cortex || neocortex-neocortex || [visual system (ParietalCortex -> FrontalCortex, abstract)] || || || NMA.NC.PMC.F4 || NSA.NC.IPS.AIP || Anterior Intraparietal Sulcus || neocortex-neocortex || [Control of Grasping (AIP -> F4)] || || || || NSA.NC.IPS.VIP || Ventral Intraparietal Sulcus || neocortex-neocortex || [Control of Grasping (VIP -> F4)] || || || || NSA.NC.STG.A3 || Wernicke's area A3 || neocortex-neocortex || [Auditory Processing (ST -> VLPFC, abstract)] || || || || NSA.NC.STG.A4 || Wernicke's area A4 || neocortex-neocortex || [Regions (pSTC -> PMC, abstract)] || || || NMA.NC.PMC.F5 || NSA.NC.IPS.AIP || Anterior Intraparietal Sulcus || neocortex-neocortex || [Control of Grasping (AIP -> F5)] || || || || NSA.NC.PG.S1 || Primary Somatosensory Cortex || neocortex-neocortex || [Control of Grasping (S2 -> F5)] || || || NMA.NC.PMC.F7 || NSA.NC.TTG.A1 || Primary Auditory Cortex || neocortex-neocortex || [Auditory Processing (A1 -> DLPFC, abstract)] || || Subcortical || || || || || || || FEC || NMA.FD.TH.VA || FEC.FT.GPI.DS || Globus Pallidus Internal Dorsal || nucleus-nucleus-gaba || [relationships (sVA -> VA, abstract)] || || || || FEC.FT.GPI.MED || Globus Pallidus Internal Medial || nucleus-nucleus-gaba || [relationships (sVA -> VA, abstract)] || || || || FEC.FT.SNR.DL || Substantia Nigra Pars Reticulata Dorsolateral || nucleus-nucleus-gaba || [relationships (sVA -> VA, abstract)] || || LRC || NMA.FD.TH.VA || LRC.MM.SC.INT || Intermediate Superior Colliculus || nucleus-nucleus || [Vision (SCi -> Thalamus, abstract)] ||

External Outbound Region Connections:*

|| Target Area || Local Region || Target Region || Target Name || Type || Reference || || Cortical || || || || || || || NDM || NMA.NC.PMC.F4 || NDM.NC.AL.DLPFCL || Lateral Mid-Dorsolateral Prefrontal Cortex || neocortex-neocortex || [Connectivity (MA -> PFC, abstract)] || || NMA || NMA.FD.TH.VA || NMA.NC.SMC.F3 || Supplementary Motor Area || nucleus-neocortex || [relationships (VA -> pVA, abstract)] || || || NMA.NC.PMC.F2 || NMA.NC.MC || Motor Cortex || neocortex-neocortex || [Cortex (PFC) in motor behavior (PMC -> MC, abstract)] || || || NMA.NC.PMC.F4 || NMA.NC.SMC.F3 || Supplementary Motor Area || neocortex-neocortex || (unknown reference) || || || NMA.NC.PMC.F5 || NMA.NC.MC || Motor Cortex || neocortex-neocortex || [Control of Grasping (F5 -> F1)] || || NPE || NMA.NC.PMC.F7 || NPE.NC.SPL.SA || Somatosensory Association Cortex || neocortex-neocortex || [Connectivity (MA -> SA, abstract)] || || Subcortical || || || || || || || FEC || NMA.NC.PMC.F2 || FEC.FT.PU.MED || Dorsal Putamen Medial || neocortex-nucleus || (unknown reference) || || || NMA.NC.PMC.F5 || FEC.FT.PU.MED || Dorsal Putamen Medial || neocortex-nucleus || (unknown reference) ||