Difference between revisions of "BrainAreaLMC"

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| '''ID''' || '''Name''' || '''Regions'''
 
| '''ID''' || '''Name''' || '''Regions'''
 
|-
 
|-
| 5HT || Serotonin - Feelings of Well-Being and Happiness || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]], [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]], [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]], [[BrainRegionLMC_HP_RP_LI|LMC.HP.RP.LI]], [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]], [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]], [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]]
+
| 5HT || Serotonin - Feelings of Well-Being and Happiness || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]], [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]], [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]], [[BrainRegionLMC_HP_RP_LI|LMC.HP.RP.LI]], [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]], [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]], [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]]
 
|-
 
|-
 
| ACH || Acetylcholine - PNS Actions and CNS plasticity, arousal and reward || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]], [[BrainRegionLMC_HT_TG_DTG|LMC.HT.TG.DTG]], [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]]
 
| ACH || Acetylcholine - PNS Actions and CNS plasticity, arousal and reward || [[BrainRegionLMC_FT_NBM|LMC.FT.NBM]], [[BrainRegionLMC_HT_TG_DTG|LMC.HT.TG.DTG]], [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]]
Line 31: Line 31:
 
| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments'''
 
| '''Component ID''' || '''Component Name''' || '''Type''' || '''Service''' || '''Function''' || '''Comments'''
 
|-
 
|-
| [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || Raphe Magnus Nucleus || nucleus || LUS || Inhubit head and spinal pain || B3, contacts with enkephalenic neurons in<BR>substantia gelatinosa
+
| [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || Raphe Magnus Nucleus || nucleus || LUS || Inhibit head and spinal pain || B3, contacts with enkephalenic neurons in<BR>substantia gelatinosa
 
|-
 
|-
 
| [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || Raphe Obscurus Nucleus || nucleus || LUS || Regulate cardiovascular function via sympathetic spinal column || B2
 
| [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || Raphe Obscurus Nucleus || nucleus || LUS || Regulate cardiovascular function via sympathetic spinal column || B2
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|-
 
|-
 
| [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || Pontine Raphe Nucleus || nucleus || LUS || Regulation of sleep cycle || Projects to CR, forebrain; inhibitory nucleus
 
| [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || Pontine Raphe Nucleus || nucleus || LUS || Regulation of sleep cycle || Projects to CR, forebrain; inhibitory nucleus
|-
 
| [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || Superior Central Raphe Nucleus || nucleus || LUS || Block or temporarily suspend mnemonic processes in the hippocampus;<BR>Hallucinations || Directs HC to disregard insignificant events;<BR>inhibitory nucleus; B6,B8; Insomnia; inhibitory<BR>nucleus
 
 
|-
 
|-
 
| [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || Dorsal Raphe Nucleus || nucleus || LUS || Regulation of sleep and mood || Major source of 5HT; inhibitory nucleus
 
| [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || Dorsal Raphe Nucleus || nucleus || LUS || Regulation of sleep and mood || Major source of 5HT; inhibitory nucleus
 +
|-
 +
| [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || Superior Central Raphe Nucleus || nucleus || LUS || Block or temporarily suspend mnemonic processes in the hippocampus;<BR>Hallucinations || Directs HC to disregard insignificant events;<BR>inhibitory nucleus; B6,B8; Insomnia; inhibitory<BR>nucleus
 
|}
 
|}
  
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|-
 
|-
 
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)]
 
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)]
|-
 
|  || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [http://www.scholarpedia.org/article/Habenula Habenula Connections (LHb -> MR, abstract)]
 
 
|-
 
|-
 
|  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)]
 
|  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)]
 +
|-
 +
|  || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || nucleus-nucleus || [http://www.scholarpedia.org/article/Habenula Habenula Connections (LHb -> MR, abstract)]
 
|-
 
|-
 
| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (IPN -> Raphe, abstract)]
 
| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || nucleus-nucleus-ACh || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (IPN -> Raphe, abstract)]
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|  || [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || [[BrainRegionLAC_FD_HT_MPO|LAC.FD.HT.MPO]] || Median Preoptic Nucleus || nucleus-nucleus || (unknown reference)
 
|  || [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || [[BrainRegionLAC_FD_HT_MPO|LAC.FD.HT.MPO]] || Median Preoptic Nucleus || nucleus-nucleus || (unknown reference)
 
|-
 
|-
| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLLC_MM_SCNF|LLC.MM.SCNF]] || Subcuneiform Nucleus || nucleus-nucleus || (unknown reference)
+
| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || nucleus-nucleus-gaba || (unknown reference)
|-
+
|  || [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || [[BrainRegionLLC_MM_SCNF|LLC.MM.SCNF]] || Subcuneiform Nucleus || nucleus-nucleus || (unknown reference)
+
|-
+
|| [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || nucleus-nucleus-gaba || (unknown reference)
+
 
|-
 
|-
 
| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus-nucleus-ENK || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 
| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus-nucleus-ENK || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 
|-
 
|-
 
|  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus-nucleus-ENK || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 
|  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || Periaqueductal Gray Matter || nucleus-nucleus-ENK || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 +
|-
 +
| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLRC_MM_SCNF|LRC.MM.SCNF]] || Subcuneiform Nucleus || nucleus-nucleus || (unknown reference)
 +
|-
 +
|  || [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || [[BrainRegionLRC_MM_SCNF|LRC.MM.SCNF]] || Subcuneiform Nucleus || nucleus-nucleus || (unknown reference)
 
|}
 
|}
  
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{| class=wikitable width=80%
 
{| class=wikitable width=80%
 
| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''
 
| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''
 +
|-
 +
| <font color="red">Cortical</font> || || || || ||
 +
|-
 +
| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || nucleus-nucleus-5HT || (unknown reference)
 
|-
 
|-
 
| <font color="red">Subcortical</font> || || || || ||
 
| <font color="red">Subcortical</font> || || || || ||
 
|-
 
|-
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionFAM_FT_SEP_LT|FAM.FT.SEP.LT]] || Lateral Septal Nucleus || nucleus-nucleus-5HT || (unknown reference)
+
| [[BrainAreaFAM|FAM]] || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionFAM_FT_SEP_LT|FAM.FT.SEP.LT]] || Lateral Septal Nucleus || nucleus-nucleus-5HT || (unknown reference)
 
|-
 
|-
| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionFEC_FD_STN_ICD|FEC.FD.STN.ICD]] || Subthalamic Nucleus Internal Caudal || nucleus-nucleus-5HT || (unknown reference)
+
| [[BrainAreaFEC|FEC]] || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionFEC_FD_STN_ICD|FEC.FD.STN.ICD]] || Subthalamic Nucleus Internal Caudal || nucleus-nucleus-5HT || (unknown reference)
 
|-
 
|-
| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionFMM_FD_MB_MMB|FMM.FD.MB.MMB]] || Medial Mammillary Nucleus || nucleus-nucleus-5HT || (unknown reference)
+
| [[BrainAreaFMM|FMM]] || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionFMM_FD_MB_MMB|FMM.FD.MB.MMB]] || Medial Mammillary Nucleus || nucleus-nucleus-5HT || (unknown reference)
 
|-
 
|-
| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_RF_SUC|LMC.MM.RF.SUC]] || [[BrainRegionLAC_FD_HT_PN|LAC.FD.HT.PN]] || Posterior Hypothalamic Nucleus || nucleus-nucleus-5HT || (unknown reference)
+
| [[BrainAreaLAC|LAC]] || [[BrainRegionLMC_MM_RP_SUC|LMC.MM.RP.SUC]] || [[BrainRegionLAC_FD_HT_PN|LAC.FD.HT.PN]] || Posterior Hypothalamic Nucleus || nucleus-nucleus-5HT || (unknown reference)
 
|-
 
|-
 
|  ||  || [[BrainRegionLAC_FD_HT_SUM|LAC.FD.HT.SUM]] || Supramammillary Nucleus || nucleus-nucleus-5HT || (unknown reference)
 
|  ||  || [[BrainRegionLAC_FD_HT_SUM|LAC.FD.HT.SUM]] || Supramammillary Nucleus || nucleus-nucleus-5HT || (unknown reference)
 
|-
 
|-
| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || [[BrainRegionLLC_HT_CR_SC|LLC.HT.CR.SC]] || Spinocerebellum || nucleus-allocortex-5HT || (unknown reference)
+
| [[BrainAreaLLC|LLC]] || [[BrainRegionLMC_HL_RP_OB|LMC.HL.RP.OB]] || [[BrainRegionLLC_HT_CR_PV|LLC.HT.CR.PV]] || Cerebellar Paravermis || nucleus-allocortex-5HT || (unknown reference)
 
|-
 
|-
|  || [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || [[BrainRegionLLC_HT_CR_SC|LLC.HT.CR.SC]] || Spinocerebellum || nucleus-allocortex-5HT || (unknown reference)
+
|  || [[BrainRegionLMC_HP_RP_PRN|LMC.HP.RP.PRN]] || [[BrainRegionLLC_HT_CR_PV|LLC.HT.CR.PV]] || Cerebellar Paravermis || nucleus-allocortex-5HT || (unknown reference)
 
|-
 
|-
 
| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLPC_SC_PH_LSG|LPC.SC.PH.LSG]] || Lower Substantia Gelatinosa || nucleus-nucleus-5HT || (unknown reference)
 
| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || [[BrainRegionLPC_SC_PH_LSG|LPC.SC.PH.LSG]] || Lower Substantia Gelatinosa || nucleus-nucleus-5HT || (unknown reference)
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|-
 
|-
 
|  ||  || [[BrainRegionLPC_SC_PH_UMG|LPC.SC.PH.UMG]] || Upper Marginal Nucleus || nucleus-nucleus-5HT || (unknown reference)
 
|  ||  || [[BrainRegionLPC_SC_PH_UMG|LPC.SC.PH.UMG]] || Upper Marginal Nucleus || nucleus-nucleus-5HT || (unknown reference)
|-
 
|  || [[BrainRegionLMC_MM_RP_DRN|LMC.MM.RP.DRN]] || [[BrainRegionLPC_FD_TH_PV|LPC.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || nucleus-nucleus-5HT || (unknown reference)
 
 
|}
 
|}
  
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{| class=wikitable width=80%
 
{| class=wikitable width=80%
 
| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''
 
| '''Target Area''' || '''Local Region''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''
 +
|-
 +
| <font color="red">Cortical</font> || || || || ||
 +
|-
 +
| [[BrainAreaNDM|NDM]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || nucleus-nucleus-ENK || (unknown reference)
 
|-
 
|-
 
| <font color="red">Subcortical</font> || || || || ||
 
| <font color="red">Subcortical</font> || || || || ||
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|  ||  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || Raphe Pallidus Nucleus || nucleus-nucleus-ENK || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 
|  ||  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || Raphe Pallidus Nucleus || nucleus-nucleus-ENK || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 
|-
 
|-
| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLPC_FD_TH_PV|LPC.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || nucleus-nucleus-ENK || (unknown reference)
+
| [[BrainAreaLPC|LPC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLPC_HL_AMB|LPC.HL.AMB]] || Ambiguus Nucleus || nucleus-nucleus-ENK || (unknown reference)
|-
+
|  ||  || [[BrainRegionLPC_HL_AMB|LPC.HL.AMB]] || Ambiguus Nucleus || nucleus-nucleus-ENK || (unknown reference)
+
 
|-
 
|-
 
| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLRC_HL_RA|LRC.HL.RA]] || Retroambigualis Nucleus || nucleus-nucleus-ENK || (unknown reference)
 
| [[BrainAreaLRC|LRC]] || [[BrainRegionLMC_MM_PAG|LMC.MM.PAG]] || [[BrainRegionLRC_HL_RA|LRC.HL.RA]] || Retroambigualis Nucleus || nucleus-nucleus-ENK || (unknown reference)

Revision as of 01:46, 24 January 2016

Modulatory Contol Area

Home -> BiologicalLifeResearch -> BrainAreaLMC


Local Circuits

(generated)

ID Name Regions
5HT Serotonin - Feelings of Well-Being and Happiness LMC.HL.RP.MG, LMC.HL.RP.OB, LMC.HL.RP.PL, LMC.HP.RP.LI, LMC.HP.RP.PRN, LMC.MM.RP.DRN, LMC.MM.RP.SUC
ACH Acetylcholine - PNS Actions and CNS plasticity, arousal and reward LMC.FT.NBM, LMC.HT.TG.DTG, LMC.HT.TG.LDT
DA Dopamine - Reward-Motivated Behavior, Cognitive Alertness LMC.MM.VTA
ENK Enkephalin - Regulating Nociception in Body LMC.MM.PAG
NE Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response LMC.HT.LC

Serotonin - Feelings of Well-Being and Happiness

unavailable

Component ID Component Name Type Service Function Comments
LMC.HL.RP.MG Raphe Magnus Nucleus nucleus LUS Inhibit head and spinal pain B3, contacts with enkephalenic neurons in
substantia gelatinosa
LMC.HL.RP.OB Raphe Obscurus Nucleus nucleus LUS Regulate cardiovascular function via sympathetic spinal column B2
LMC.HL.RP.PL Raphe Pallidus Nucleus nucleus LUS Spinal pain control B1
LMC.HP.RP.LI Raphe Nucleus Linearis nucleus LUS Release of 5-HT was only obtained on stimulation of this nucleus B8, Does not project to CR, but to forebrain, to
dorsal raphe nucleus (lies above DRN); dendrites to
vascular plexus, maybe sensing blood pressure
LMC.HP.RP.PRN Pontine Raphe Nucleus nucleus LUS Regulation of sleep cycle Projects to CR, forebrain; inhibitory nucleus
LMC.MM.RP.DRN Dorsal Raphe Nucleus nucleus LUS Regulation of sleep and mood Major source of 5HT; inhibitory nucleus
LMC.MM.RP.SUC Superior Central Raphe Nucleus nucleus LUS Block or temporarily suspend mnemonic processes in the hippocampus;
Hallucinations
Directs HC to disregard insignificant events;
inhibitory nucleus; B6,B8; Insomnia; inhibitory
nucleus

Internal Region Connections:

Source Region Target Region Type Reference
LMC.HP.RP.LI LMC.MM.RP.DRN nucleus-nucleus-5HT (unknown reference)

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Subcortical
FAM LMC.HL.RP.MG FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)
LMC.MM.RP.DRN FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)
LMC.MM.RP.SUC FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus Habenula Connections (LHb -> MR, abstract)
FEC LMC.HL.RP.MG FEC.HT.TG.IPD Interpeduncular Nucleus nucleus-nucleus-ACh Connectivity map of the habenula (IPN -> Raphe, abstract)
FEC.HT.TG.RMTG Rostromedial Tegmental Nucleus nucleus-nucleus-gaba Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> MRN, abstract)
LMC.MM.RP.DRN FEC.HT.TG.IPD Interpeduncular Nucleus nucleus-nucleus-ACh Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> DRN)
FEC.HT.TG.RMTG Rostromedial Tegmental Nucleus nucleus-nucleus-gaba Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> DRN)
LAC LMC.HL.RP.MG LAC.FD.HT.LTN Lateral Hypothalamic Nucleus nucleus-nucleus (unknown reference)
LAC.FD.HT.PV Paraventricular Nucleus nucleus-nucleus (unknown reference)
LMC.HL.RP.OB LAC.FD.HT.MPO Median Preoptic Nucleus nucleus-nucleus (unknown reference)
LLC LMC.MM.RP.DRN LLC.FD.TH.SF Subfascicular Nucleus of Thalamus nucleus-nucleus-gaba (unknown reference)
LMC LMC.HL.RP.MG LMC.MM.PAG Periaqueductal Gray Matter nucleus-nucleus-ENK Connectivity map of the habenula (PAG -> Raphe, abstract)
LMC.HL.RP.PL LMC.MM.PAG Periaqueductal Gray Matter nucleus-nucleus-ENK Connectivity map of the habenula (PAG -> Raphe, abstract)
LRC LMC.HL.RP.MG LRC.MM.SCNF Subcuneiform Nucleus nucleus-nucleus (unknown reference)
LMC.HP.RP.PRN LRC.MM.SCNF Subcuneiform Nucleus nucleus-nucleus (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NDM LMC.MM.RP.DRN NDM.FD.TH.PV Paraventricular Nucleus of Thalamus nucleus-nucleus-5HT (unknown reference)
Subcortical
FAM LMC.MM.RP.SUC FAM.FT.SEP.LT Lateral Septal Nucleus nucleus-nucleus-5HT (unknown reference)
FEC LMC.MM.RP.SUC FEC.FD.STN.ICD Subthalamic Nucleus Internal Caudal nucleus-nucleus-5HT (unknown reference)
FMM LMC.MM.RP.SUC FMM.FD.MB.MMB Medial Mammillary Nucleus nucleus-nucleus-5HT (unknown reference)
LAC LMC.MM.RP.SUC LAC.FD.HT.PN Posterior Hypothalamic Nucleus nucleus-nucleus-5HT (unknown reference)
LAC.FD.HT.SUM Supramammillary Nucleus nucleus-nucleus-5HT (unknown reference)
LLC LMC.HL.RP.OB LLC.HT.CR.PV Cerebellar Paravermis nucleus-allocortex-5HT (unknown reference)
LMC.HP.RP.PRN LLC.HT.CR.PV Cerebellar Paravermis nucleus-allocortex-5HT (unknown reference)
LPC LMC.HL.RP.MG LPC.SC.PH.LSG Lower Substantia Gelatinosa nucleus-nucleus-5HT (unknown reference)
LPC.SC.PH.USG Upper Substantia Gelatinosa nucleus-nucleus-5HT (unknown reference)
LMC.HL.RP.OB LPC.SC.IZ.IMM Intermediomedial Nucleus nucleus-nucleus-5HT (unknown reference)
LMC.HL.RP.PL LPC.SC.PH.LMG Lower Marginal Nucleus nucleus-nucleus-5HT (unknown reference)
LPC.SC.PH.UMG Upper Marginal Nucleus nucleus-nucleus-5HT (unknown reference)

Acetylcholine - PNS Actions and CNS plasticity, arousal and reward

unavailable

Component ID Component Name Type Service Function Comments
LMC.FT.NBM Basal Nucleus of Meynert nucleus FAU Control imagination vs perception ACh source, attention; modulatory nucleus
LMC.HT.TG.DTG Dorsal Tegmental Nucleus nucleus LUS accurate landmark navigation vestibular sensory information to mammllary bodies
for orientation
LMC.HT.TG.LDT Laterodorsal Tegmental Nucleus nucleus LUS Modulating sustained attention or in mediating alerting responses sleep, waking, motor function, learning and reward

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NSA LMC.HT.TG.LDT NSA.FD.TH.SG Suprageniculate Nucleus of Thalamus nucleus-nucleus (unknown reference)
Subcortical
FAM LMC.FT.NBM FAM.FT.AM.AB Accessory Basal Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.AM.BP Parvicellular Basal Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.BNST Bed Nucleus of Stria Terminalis nucleus-nucleus (unknown reference)
LMC.HT.TG.DTG FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> DTG)
FEC LMC.FT.NBM FEC.FD.STN.CD Subthalamic Nucleus Caudal nucleus-nucleus (unknown reference)
FEC.FT.ACC.SH Nucleus Accumbens Shell nucleus-nucleus-gaba Affective basal ganglia circuit (NACC -> nBM, abstract)
LMC.HT.TG.DTG FEC.HT.TG.IPD Interpeduncular Nucleus nucleus-nucleus-ACh Head Direction Cell Circuit (IPD -> DTN)
LMC.HT.TG.LDT FEC.HT.TG.RMTG Rostromedial Tegmental Nucleus nucleus-nucleus-gaba (unknown reference)
FMM LMC.HT.TG.LDT FMM.FD.MB.LMB Lateral Mammillary Nucleus nucleus-nucleus Hippocampal Formation (LMam -> DTN)
LAC LMC.HT.TG.LDT LAC.FD.HT.VLPO Ventrolateral Preoptic Nucleus nucleus-nucleus Simplified NREM sleep-promoting pathway (VLPO -> LDTg)
LRC LMC.HT.TG.DTG LRC.HL.NPH Prepositus Nucleus nucleus-nucleus (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NDM LMC.FT.NBM NDM.NC.AL.FPC Lateral Frontopolar Cortex nucleus-neocortex-ACh Physiology and pathophysiology of lower urinary tract (NBM -> MPFC, abstract)
NSA LMC.FT.NBM NSA.NC.OCC.V1 Primary Visual Cortex nucleus-neocortex-ACh (unknown reference)
LMC.HT.TG.DTG NSA.FD.TH.SG Suprageniculate Nucleus of Thalamus nucleus-nucleus-ACh Head Direction Cell Circuit (DTN -> SUPGEN)
Subcortical
FAM LMC.FT.NBM FAM.FT.AM.BM Magnocellular Basal Amygdaloid Nucleus nucleus-nucleus-ACh (unknown reference)
FEC LMC.HT.TG.LDT FEC.HT.TG.IPD Interpeduncular Nucleus nucleus-nucleus-ACh (unknown reference)
FMM LMC.HT.TG.DTG FMM.FD.MB.LMB Lateral Mammillary Nucleus nucleus-nucleus-ACh (unknown reference)
LAC LMC.HT.TG.LDT LAC.HL.SAL.ISL Inferior Salivatory Nucleus nucleus-nucleus-ACh (unknown reference)
LAC.HL.SAL.SSL Superior Salivatory Nucleus nucleus-nucleus-ACh (unknown reference)
LRC LMC.HT.TG.LDT LRC.HL.NPH Prepositus Nucleus nucleus-nucleus-ACh (unknown reference)

Dopamine - Reward-Motivated Behavior, Cognitive Alertness

unavailable

Component ID Component Name Type Service Function Comments
LMC.MM.VTA Ventral Tegmental Area nucleus LUS Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Subcortical
FAM LMC.MM.VTA FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)
FAM.FT.BNST Bed Nucleus of Stria Terminalis nucleus-nucleus (unknown reference)
FEC LMC.MM.VTA FEC.FT.ACC.CORE Nucleus Accumbens Core nucleus-nucleus-gaba Reward circuit of human brain (NACC -> VTA, abstract)
FEC.FT.VP.VM Ventral Pallidum Ventromedial nucleus-nucleus-gaba Craving (VPAL -> VTA, abstract)
FEC.HT.TG.IPD Interpeduncular Nucleus nucleus-nucleus-ACh Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> VTA)
FEC.HT.TG.RMTG Rostromedial Tegmental Nucleus nucleus-nucleus-gaba Amygdala and its network (RMTG -> VTA)
LPC LMC.MM.VTA LPC.HL.SOL Solitary Nucleus nucleus-nucleus Bowels control brain: gut hormones and obesity (NTS -> VTA)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NDM LMC.MM.VTA NDM.NC.AL.DACG Dorsal Anterior Cingulate Area nucleus-neocortex-DA (unknown reference)
NDM.NC.AL.FPC Lateral Frontopolar Cortex nucleus-neocortex-DA Amygdala and its network (VTA -> MPFC, abstract)
Subcortical
FAM LMC.MM.VTA FAM.FT.AM.CEC Central Amygdaloid Nucleus, capsular subdivision nucleus-nucleus-DA Reward circuit of human brain (VTA -> AM, abstract)
FEC LMC.MM.VTA FEC.FT.ACC.SH Nucleus Accumbens Shell nucleus-nucleus-DA Craving (VTA -> NACC, abstract)
FEC.FT.PU.LT Dorsal Putamen Lateral nucleus-nucleus-DA Bowels control brain: gut hormones and obesity (VTA -> DS, abstract)
FEC.FT.PU.MED Dorsal Putamen Medial nucleus-nucleus-DA Bowels control brain: gut hormones and obesity (VTA -> DS, abstract)
FMM LMC.MM.VTA FMM.FD.MB.MMB Medial Mammillary Nucleus nucleus-nucleus-DA Mammillary bodies: two memory systems in one (VTN -> MMB)
FMM.FT.HC.CA1D Distal CA1 of Hippocampus nucleus-allocortex-DA Reward circuit of human brain (VTA -> HC, abstract)
FMM.NC.PH.LEC Lateral Entorhinal Cortex nucleus-neocortex-DA Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)
LAC LMC.MM.VTA LAC.FD.HT.PRM Premammillary Nucleus nucleus-nucleus-DA (unknown reference)
LAC.FD.HT.PV Paraventricular Nucleus nucleus-nucleus-DA Physiology and pathophysiology of lower urinary tract (VTA -> PVN)

Enkephalin - Regulating Nociception in Body

unavailable

Component ID Component Name Type Service Function Comments
LMC.MM.PAG Periaqueductal Gray Matter nucleus LUS Descending modulation of pain and in defensive behaviour if there is a lesion in the PAG, then consciousness
is lost; electrical stimulation of the PAG results
in immediate and profound analgesia; modulatory
nucleus

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NCP LMC.MM.PAG NCP.NC.AL.SGCG Subgenual Cingulate Cortex neocortex-nucleus (unknown reference)
Subcortical
FAM LMC.MM.PAG FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus-nucleus Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)
FEC LMC.MM.PAG FEC.HT.TG.IPD Interpeduncular Nucleus nucleus-nucleus-ACh Connectivity map of the habenula (IPN -> PAG)
LAC LMC.MM.PAG LAC.FD.HT.VM Ventromedial Hypothalamic Nucleus nucleus-nucleus Spine induction on short primary dendrites in the ventrolateral VMH (VMH -> PAG)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NDM LMC.MM.PAG NDM.FD.TH.PV Paraventricular Nucleus of Thalamus nucleus-nucleus-ENK (unknown reference)
Subcortical
LAC LMC.MM.PAG LAC.HT.BR Barrington's Nucleus nucleus-nucleus-ENK Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)
LLC LMC.MM.PAG LLC.FD.TH.SF Subfascicular Nucleus of Thalamus nucleus-nucleus-ENK (unknown reference)
LMC LMC.MM.PAG LMC.HL.RP.MG Raphe Magnus Nucleus nucleus-nucleus-ENK Connectivity map of the habenula (PAG -> Raphe, abstract)
LMC.HL.RP.PL Raphe Pallidus Nucleus nucleus-nucleus-ENK Connectivity map of the habenula (PAG -> Raphe, abstract)
LPC LMC.MM.PAG LPC.HL.AMB Ambiguus Nucleus nucleus-nucleus-ENK (unknown reference)
LRC LMC.MM.PAG LRC.HL.RA Retroambigualis Nucleus nucleus-nucleus-ENK (unknown reference)
LRC.HT.NSC Nucleus Subceruleus nucleus-nucleus-ENK (unknown reference)

Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response

unavailable

Component ID Component Name Type Service Function Comments
LMC.HT.LC Locus Coeruleus nucleus LUS Regulate the intensity of responses to salient stimuli NE Source, enhance signal-to-noise ratio,
suppressing irrelevant stimuli (lateral
inhibition); inhibitory nucleus

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NDM LMC.HT.LC NDM.NC.AL.VACG Ventral Anterior Cingulate Area neocortex-nucleus (unknown reference)
Subcortical
FAM LMC.HT.LC FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus-nucleus Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)
FAM.FT.BNST Bed Nucleus of Stria Terminalis nucleus-nucleus (unknown reference)
LAC LMC.HT.LC LAC.FD.HT.DM Dorsomedial Hypothalamic Nucleus nucleus-nucleus Effect of light on pupil diameter (DMH -> LC)
LAC.FD.HT.TBM Tuberomammillary Nucleus nucleus-nucleus (unknown reference)
LRC LMC.HT.LC LRC.HL.RF.MED Central Medullary Reticular Nucleus nucleus-nucleus (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Subcortical
FAM LMC.HT.LC FAM.FD.LHB.LT Lateral Habenula Lateral Part nucleus-nucleus-NE Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus-NE Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
FAM.FD.MHB Medial Habenula nucleus-nucleus-NE Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)
FAM.FT.SEP.DBB Diagonal Band of Broca nucleus-nucleus-NE (unknown reference)
FEC LMC.HT.LC FEC.FT.SNC.MED Substantia Nigra Pars Compacta Medial nucleus-nucleus-NE (unknown reference)
FEC.HT.TG.IPD Interpeduncular Nucleus nucleus-nucleus-NE Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)
LAC LMC.HT.LC LAC.FD.HT.VLPO Ventrolateral Preoptic Nucleus nucleus-nucleus-NE Simplified NREM sleep-promoting pathway (LC -> VLPO)
LAC.SC.IZ.CSC Ciliospinal Center nucleus-nucleus-NE Effect of light on pupil diameter (LC -> IML)
LAC.SC.IZ.IML Intermediolateral Nucleus nucleus-nucleus-NE Physiology and pathophysiology of lower urinary tract (LC -> IML)

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References

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