BrainRegionLAC FD HT LTN

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Lateral Hypothalamic Nucleus

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This page covers biological details of component Lateral Hypothalamic Nucleus. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Lateral Hypothalamic Area (LAC.FD.HT.LT) -> Lateral Hypothalamic Nucleus (LAC.FD.HT.LTN) (see Mind Maps)
  • Type: nucleus
  • Brain area: Lower Brain - Autonomous Control Area
  • Role: processor.autonomic
  • Function: feeding center
  • Notes to function: lesions - lack of appetite

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Components

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  • no child items defined

Connectivity

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LAC.FD.HT.LTN.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FAM FAM.FT.AM.BP Parvicellular Basal Amygdaloid Nucleus excitatory-glu Amygdala and its network (BLN -> HTS)
FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus excitatory-glu Amygdalar disruption of prefrontal cortex (AM -> HT.L, abstract)
FAM.FT.SEP.SH Septohippocampal Nucleus excitatory-glu Cingulate Gyrus (SEP -> HT, abstract)
FEC FEC.FT.ACC.SH Nucleus Accumbens Shell inhibitory-gaba (unknown reference)
LAC LAC.FD.HT.AR Arcuate Nucleus of Hypothalamus excitatory-glu Intrahypothalamic connections important for neural control of food intake and energy balance (ARC -> LHA)
LAC.FD.HT.DM Dorsomedial Hypothalamic Nucleus excitatory-glu Eating and sleeping to survive (DMH -> LHA)
LAC.FD.HT.VM Ventromedial Hypothalamic Nucleus excitatory-glu Glucose-sensing neural network (VMH -> LHA)
LPC LPC.HL.SOL Solitary Nucleus excitatory-glu Schematic of hypothalamic circuitry underlying satiety (NTS -> LHA)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FAM FAM.FD.LHB.LT Lateral Habenula Lateral Part excitatory-glu Regulation of the rapid eye movement (REM) sleep by habenular projection (LHT -> LHbL)
FAM.FD.LHB.MED Lateral Habenula Medial Part excitatory-glu Both LHb and MHb control the dopaminergic and serotonergic systems (LHA -> LHbM)
LAC LAC.FD.HT.PV Paraventricular Nucleus excitatory-glu Schematic of hypothalamic circuitry underlying satiety (LHA -> PVN)
LMC LMC.HL.RP.MG Raphe Magnus Nucleus excitatory-glu (unknown reference)
NDM NDM.NC.AL.ROFCS Sulcal Rostral Orbitofrontal Cortex excitatory-glu Bowels control brain: gut hormones and obesity (LHA -> OFC, abstract)

Thirdparty Circuits

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map: ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, NTS=Solitary Nucleus,LPC.HL.SOL, PVN=Paraventricular Nucleus,LAC.FD.HT.PV, VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM unavailable

map: AMY=Amygdala,FAM.FT.AM, ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DS=Dorsal Striatum,FEC.FT.DST (Caudate Nucleus Head (FEC.FT.CN.HD), Caudate Nucleus Body (FEC.FT.CN.BD), Caudate Nucleus Tail (FEC.FT.CN.TL), Dorsal Putamen Lateral (FEC.FT.PU.LT), Dorsal Putamen Medial (FEC.FT.PU.MED)), LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, ME=Endocrine Glands,TARGET.TEA.ENDOCRINE, NAc=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), NTS=Solitary Nucleus,LPC.HL.SOL, OFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)), PBN=Parabrachial Nucleus,LPC.HT.PRF.PB, PVN=Paraventricular Nucleus,LAC.FD.HT.PV, VMN=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM, VTA=Ventral Tegmental Area,LMC.MM.VTA unavailable

map: DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB, DTG=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG, EPN=Endopiriform Nucleus,FAM.FT.EPF, GPi=Globus Pallidus Internal,FEC.FT.GPI (Globus Pallidus Internal Lateral (FEC.FT.GPI.LT), Globus Pallidus Internal Medial (FEC.FT.GPI.MED), Globus Pallidus Internal Dorsal (FEC.FT.GPI.DS), Globus Pallidus Internal Rostromedial (FEC.FT.GPI.RM), Globus Pallidus Internal Dorsolateral (FEC.FT.GPI.DL)), LHT=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT, LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED, NI=Incertus Nucleus,FAM.HT.TG.NI, RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG, Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (Raphe Pallidus Nucleus (LMC.HL.RP.PL), Raphe Obscurus Nucleus (LMC.HL.RP.OB), Raphe Magnus Nucleus (LMC.HL.RP.MG)), SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (Substantia Nigra Pars Compacta Lateral (FEC.FT.SNC.LT), Substantia Nigra Pars Compacta Medial (FEC.FT.SNC.MED)), VTA=Ventral Tegmental Area,LMC.MM.VTA, VTG=Ventral Tegmental Area,LMC.MM.VTG unavailable

map: DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB, DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN, GPb=Dorsal Pallidum,FEC.FT.DP (Globus Pallidus External Lateral (FEC.FT.GPE.LT), Globus Pallidus External Medial (FEC.FT.GPE.MED), Globus Pallidus External Dorsal (FEC.FT.GPE.DS), Globus Pallidus External Rostromedial (FEC.FT.GPE.RM), Globus Pallidus External Dorsolateral (FEC.FT.GPE.DL), Globus Pallidus Internal Lateral (FEC.FT.GPI.LT), Globus Pallidus Internal Medial (FEC.FT.GPI.MED), Globus Pallidus Internal Dorsal (FEC.FT.GPI.DS), Globus Pallidus Internal Rostromedial (FEC.FT.GPI.RM), Globus Pallidus Internal Dorsolateral (FEC.FT.GPI.DL)), IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT, LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED, LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO, LS=Lateral Septal Nucleus,FAM.FT.SEP.LT, MHb=Medial Habenula,FAM.FD.MHB, MRN=Raphe Nuclei of Medulla,LMC.HL.RP (Raphe Pallidus Nucleus (LMC.HL.RP.PL), Raphe Obscurus Nucleus (LMC.HL.RP.OB), Raphe Magnus Nucleus (LMC.HL.RP.MG)), MS=Medial Septal Nucleus,FAM.FT.SEP.MED, PS=Posterior Septal Group,FAM.FT.SEP.PG (Bed Nucleus of Anterior Commissure (FAM.FT.SEP.BAC), Septofimbrial Nucleus (FAM.FT.SEP.SF), Triangular Septal Nucleus (FAM.FT.SEP.TR)), RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG, SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (Substantia Nigra Pars Compacta Lateral (FEC.FT.SNC.LT), Substantia Nigra Pars Compacta Medial (FEC.FT.SNC.MED)), VP=Ventral Pallidum,FEC.FT.VP (Ventral Pallidum Dorsolateral (FEC.FT.VP.DL), Ventral Pallidum Ventromedial (FEC.FT.VP.VM)), VTA=Ventral Tegmental Area,LMC.MM.VTA unavailable

map: B=Basal Amygdaloid Nucleus,FAM.FT.AM.B (Parvicellular Basal Amygdaloid Nucleus (FAM.FT.AM.BP), Magnocellular Basal Amygdaloid Nucleus (FAM.FT.AM.BM)), CE=Central Amygdala,FAM.FT.AM.CEA (Central Amygdaloid Nucleus, capsular subdivision (FAM.FT.AM.CEC), Central Amygdaloid Nucleus, lateral subdivision (FAM.FT.AM.CEL), Medial Central Amygdaloid Nucleus (FAM.FT.AM.CEM)), Hippocampus=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), Hypothalamus=Hypothalamus,FD.HT, ITC=Intercalated Amygdaloid Nuclei,FAM.FT.AM.ITC, LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (Dorsolateral Amygdaloid Nucleus (FAM.FT.AM.LADL), Ventrolateral Amygdaloid Nucleus (FAM.FT.AM.LAVL), Ventromedial Amygdaloid Nucleus (FAM.FT.AM.LAVM)), Striatum=Striatum,FEC.FT.ST (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH), Ventral Putamen (FEC.FT.PU.VT), Caudate Nucleus Head (FEC.FT.CN.HD), Caudate Nucleus Body (FEC.FT.CN.BD), Caudate Nucleus Tail (FEC.FT.CN.TL), Dorsal Putamen Lateral (FEC.FT.PU.LT), Dorsal Putamen Medial (FEC.FT.PU.MED)), dlPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (Rostral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCR), Lateral Mid-Dorsolateral Prefrontal Cortex (NDM.NC.AL.DLPFCL)), vmPFC=Ventromedial Prefrontal Cortex,NDM.NC.AL.VMPFC unavailable

map: ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DMN=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, PVH=Paraventricular Nucleus,LAC.FD.HT.PV, VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM unavailable

map: DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, NTS=Solitary Nucleus,LPC.HL.SOL, PBN=Parabrachial Nucleus,LPC.HT.PRF.PB, PVH=Paraventricular Nucleus,LAC.FD.HT.PV, SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN unavailable

map: ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, MPO=Median Preoptic Nucleus,LAC.FD.HT.MPO, PVH=Paraventricular Nucleus,LAC.FD.HT.PV, SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN, VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO, VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM unavailable

map: AH=Anterior Hypothalamic Nucleus,LAC.FD.HT.AH, ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DMN=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO, PA=Paraventricular Nucleus,LAC.FD.HT.PV, SCH=Suprachiasmatic Nucleus,LAC.FD.HT.SCN, SON=Supraoptic Nucleus,LAC.FD.HT.SO, VMN=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM unavailable

map: CPu=Striatum,FEC.FT.ST (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH), Ventral Putamen (FEC.FT.PU.VT), Caudate Nucleus Head (FEC.FT.CN.HD), Caudate Nucleus Body (FEC.FT.CN.BD), Caudate Nucleus Tail (FEC.FT.CN.TL), Dorsal Putamen Lateral (FEC.FT.PU.LT), Dorsal Putamen Medial (FEC.FT.PU.MED)), EP=Endopiriform Nucleus,FAM.FT.EPF, Hippo=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD, L=Lateral Habenula,FAM.FD.LHB (Lateral Habenula Medial Part (FAM.FD.LHB.MED), Lateral Habenula Lateral Part (FAM.FD.LHB.LT)), LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, M=Medial Habenula,FAM.FD.MHB, NAc=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), PAG=Periaqueductal Gray Matter,LMC.MM.PAG, Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (Raphe Pallidus Nucleus (LMC.HL.RP.PL), Raphe Obscurus Nucleus (LMC.HL.RP.OB), Raphe Magnus Nucleus (LMC.HL.RP.MG)), SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (Substantia Nigra Pars Compacta Lateral (FEC.FT.SNC.LT), Substantia Nigra Pars Compacta Medial (FEC.FT.SNC.MED)), Septum=Septal Nuclei,FAM.FT.SEP, VTA=Ventral Tegmental Area,LMC.MM.VTA unavailable

map: BLN=Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP, CEA=Central Amygdala,FAM.FT.AM.CEA (Central Amygdaloid Nucleus, capsular subdivision (FAM.FT.AM.CEC), Central Amygdaloid Nucleus, lateral subdivision (FAM.FT.AM.CEL), Medial Central Amygdaloid Nucleus (FAM.FT.AM.CEM)), EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), HC=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), HTS=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, ITC=Inferotemporal Cortex,NSA.NC.IT.TE, LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (Dorsolateral Amygdaloid Nucleus (FAM.FT.AM.LADL), Ventrolateral Amygdaloid Nucleus (FAM.FT.AM.LAVL), Ventromedial Amygdaloid Nucleus (FAM.FT.AM.LAVM)), LHB=Lateral Habenula,FAM.FD.LHB (Lateral Habenula Medial Part (FAM.FD.LHB.MED), Lateral Habenula Lateral Part (FAM.FD.LHB.LT)), MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (Medial Mediodorsal Nucleus of Thalamus (NDM.FD.TH.MDM), Central Mediodorsal Nucleus of Thalamus (NCP.FD.TH.MDC), Lateral Mediodorsal Nucleus of Thalamus (NMA.FD.TH.MDL)), MPFC=Orbitomedial Prefrontal Cortex,NC.AL.OMPFC, NACC=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), PAG=Periaqueductal Gray Matter,LMC.MM.PAG, RMTG=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG, STC=Wernicke's area A3,NSA.NC.STG.A3, VGDM=Vagus Nucleus,LAC.HL.VGN, VTA=Ventral Tegmental Area,LMC.MM.VTA unavailable


References

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