BrainAreaFAM

Forebrain Affective Motivations Area

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Local Circuits

(generated)

ID	Name	Regions
FAMXAA	Acquisition of Avoidance Responses	FAM.FD.LHB.LT, FAM.FD.LHB.MED
FAMXCEC	Conscious Emotions Control	FAM.FT.AM.BP, FAM.FT.AM.ITC, FAM.FT.SEP.SF, FAM.FT.SEP.TR
FAMXCS	Conditional Context Sensory Data and Memory Attention	FAM.FD.TH.PT, FAM.FT.AM.AB, FAM.FT.AM.BM, FAM.FT.AM.COA, FAM.FT.AM.LADL
FAMXEFL	Express Flight Emotions	FAM.FT.AM.MEA, FAM.FT.AM.MPD, FAM.FT.AM.MPV, FAM.FT.BNST, FAM.FT.IPAC.MED, FAM.FT.SEP.BAC
FAMXEFT	Express Fight Emotions	FAM.FT.AM.CEM, FAM.FT.SEP.SH
FAMXFFD	Solving Fight-Flight Dilemma	FAM.FT.SEP.LT
FAMXMF	Memory Formation Affective Focus	FAM.FT.SEP.DBB, FAM.FT.SEP.MED
FAMXREC	Reward Emotions Control	FAM.FD.MHB, FAM.FT.EPF, FAM.HT.TG.NI
FAMXUS	Fast Unconditional Sensory Data and Association Memory	FAM.FT.AM.CEC, FAM.FT.AM.CEL, FAM.FT.AM.COP, FAM.FT.AM.LAVL, FAM.FT.AM.LAVM

Acquisition of Avoidance Responses

Component ID	Component Name	Type	Service	Function	Comments
FAM.FD.LHB.LT	Lateral Habenula Lateral Part	nucleus	FAU	Encoding negative feedback, direct, Pallidal
FAM.FD.LHB.MED	Lateral Habenula Medial Part	nucleus	FAU	Encoding negative feedback, direct, Septal

Internal Region Connections:

• no connections

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Subcortical
FAM	FAM.FD.LHB.LT	FAM.FT.EPF	Endopiriform Nucleus	nucleus-nucleus	Regulation of the rapid eye movement (REM) sleep by habenular projection (EPN -> LHbL)
	FAM.FD.LHB.MED	FAM.FD.MHB	Medial Habenula	nucleus-nucleus	Connectivity map of the habenula (M -> L, abstract)
		FAM.FT.SEP.DBB	Diagonal Band of Broca	nucleus-nucleus-gaba	Both LHb and MHb control the dopaminergic and serotonergic systems (DBB -> LHbM)
		FAM.FT.SEP.LT	Lateral Septal Nucleus	nucleus-nucleus-gaba	Both LHb and MHb control the dopaminergic and serotonergic systems (LS -> LHbM)
FEC	FAM.FD.LHB.LT	FEC.FT.ACC.CORE	Nucleus Accumbens Core	nucleus-nucleus-gaba	Connectivity map of the habenula (NAc -> L, abstract)
		FEC.FT.GPI.DS	Globus Pallidus Internal Dorsal	nucleus-nucleus-gaba	Habenula Connections (GPi -> LHb, abstract)
	FAM.FD.LHB.MED	FEC.FT.VP.VM	Ventral Pallidum Ventromedial	nucleus-nucleus-gaba	Both LHb and MHb control the dopaminergic and serotonergic systems (VP -> LHbM, abstract)
LAC	FAM.FD.LHB.LT	LAC.FD.HT.LTN	Lateral Hypothalamic Nucleus	nucleus-nucleus	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHT -> LHbL)
		LAC.FD.HT.PO	Preoptic Nucleus	nucleus-nucleus	Habenula Connections (LPO -> LHb, abstract)
	FAM.FD.LHB.MED	LAC.FD.HT.LTN	Lateral Hypothalamic Nucleus	nucleus-nucleus	Both LHb and MHb control the dopaminergic and serotonergic systems (LHA -> LHbM)
		LAC.FD.HT.PO	Preoptic Nucleus	nucleus-nucleus	Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM)
LMC	FAM.FD.LHB.LT	LMC.MM.RF.SUC	Superior Central Raphe Nucleus	nucleus-nucleus-5HT	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Subcortical
FAM	FAM.FD.LHB.MED	FAM.HT.TG.NI	Incertus Nucleus	nucleus-nucleus	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> NI)
FEC	FAM.FD.LHB.LT	FEC.HT.PPN.RMTG	Rostromedial Tegmental Nucleus	nucleus-nucleus	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbL -> RMTg)
	FAM.FD.LHB.MED	FEC.FT.SNC.LT	Substantia Nigra Pars Compacta Lateral	nucleus-nucleus	Habenula Connections (LHb -> SNc, abstract)
		FEC.HT.PPN.RMTG	Rostromedial Tegmental Nucleus	nucleus-nucleus	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> RMTg)
LMC	FAM.FD.LHB.MED	LMC.HL.RP.MG	Raphe Magnus Nucleus	nucleus-nucleus	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)
		LMC.HT.TG.DTG	Dorsal Tegmental Nucleus	nucleus-nucleus	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> DTG)
		LMC.MM.RF.SUC	Superior Central Raphe Nucleus	nucleus-nucleus	Habenula Connections (LHb -> MR, abstract)
		LMC.MM.RP.DRN	Dorsal Raphe Nucleus	nucleus-nucleus	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)
		LMC.MM.VTA	Ventral Tegmental Area	nucleus-nucleus	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)

Conscious Emotions Control

Component ID	Component Name	Type	Service	Function	Comments
FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	nucleus	FAU	enhance explicit memories in hippocampus about emotional situations
FAM.FT.AM.ITC	Intercalated Amygdaloid Nuclei	nucleus	FAU	inhibit excessive emotional behavior	inhibitory
FAM.FT.SEP.SF	Septofimbrial Nucleus	nucleus	FAU	afferent to medial habenula, primary input to indirect encoding negative feedback
FAM.FT.SEP.TR	Triangular Septal Nucleus	nucleus	FAU	afferent to medial habenula, interpeduncular nucleus

Internal Region Connections:

• no connections

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NDM	FAM.FT.AM.BP	NDM.NC.AL.DACG	Dorsal Anterior Cingulate Area	neocortex-nucleus	Role for serotonin in moral behavior (ACG -> AMY, abstract)
		NDM.NC.AL.FPC	Lateral Frontopolar Cortex	neocortex-nucleus	Amygdala and its network (MPFC -> BLN, abstract)
		NDM.NC.AL.VACG	Ventral Anterior Cingulate Area	neocortex-nucleus	Role for serotonin in moral behavior (ACG -> AMY, abstract)
	FAM.FT.AM.ITC	NDM.NC.AL.DMPFC	Dorsomedial Prefrontal Cortex	neocortex-nucleus	(unknown reference)
		NDM.NC.AL.VMPFC	Ventromedial Prefrontal Cortex	neocortex-nucleus	(unknown reference)
Subcortical
FAM	FAM.FT.AM.BP	FAM.FT.AM.LADL	Dorsolateral Amygdaloid Nucleus	nucleus-nucleus	Amygdala and its network (LA -> BLN, abstract)
		FAM.FT.AM.LAVL	Ventrolateral Amygdaloid Nucleus	nucleus-nucleus	Amygdala and its network (LA -> BLN, abstract)
	FAM.FT.AM.ITC	FAM.FT.AM.BM	Magnocellular Basal Amygdaloid Nucleus	nucleus-nucleus	(unknown reference)
		FAM.FT.AM.LADL	Dorsolateral Amygdaloid Nucleus	nucleus-nucleus	(unknown reference)
	FAM.FT.SEP.SF	FAM.HT.TG.NI	Incertus Nucleus	nucleus-nucleus-gaba	(unknown reference)
	FAM.FT.SEP.TR	FAM.HT.TG.NI	Incertus Nucleus	nucleus-nucleus-gaba	(unknown reference)
FMM	FAM.FT.SEP.SF	FMM.FT.HC.CA3D	Distal CA3 of Hippocampus	allocortex-nucleus	Connectivity map of the habenula (Hippo -> Septum, abstract)
	FAM.FT.SEP.TR	FMM.FT.HF.SUBD	Distal Subiculum	allocortex-nucleus	Principal Connections of Hippocampus (HC -> SEP, abstract)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NDM	FAM.FT.AM.BP	NDM.FD.TH.MDM	Medial Mediodorsal Nucleus of Thalamus	nucleus-nucleus	Amygdala and its network (BLN -> MD, abstract)
Subcortical
FAM	FAM.FT.AM.BP	FAM.FT.AM.BM	Magnocellular Basal Amygdaloid Nucleus	nucleus-nucleus	(unknown reference)
		FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	nucleus-nucleus	Amygdala and its network (BLN -> CEA, abstract)
	FAM.FT.AM.ITC	FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	nucleus-nucleus-gaba	(unknown reference)
	FAM.FT.SEP.SF	FAM.FD.MHB	Medial Habenula	nucleus-nucleus-gaba	Connectivity map of the habenula (Septum -> M, abstract)
	FAM.FT.SEP.TR	FAM.FD.MHB	Medial Habenula	nucleus-nucleus-gaba	Connectivity map of the habenula (Septum -> M, abstract)
FEC	FAM.FT.AM.BP	FEC.FT.ACC.CORE	Nucleus Accumbens Core	nucleus-nucleus	Amygdala and its network (BLN -> NACC, abstract)
FMM	FAM.FT.AM.BP	FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	nucleus-allocortex	Detailed amygdalohippocampal projections (Bpc -> CA1D)
		FMM.NC.PH.LEC	Lateral Entorhinal Cortex	nucleus-neocortex	Principal Connections of Hippocampus (AM -> EC, abstract)
		FMM.NC.PH.PAS	Parasubiculum	nucleus-neocortex	Detailed amygdalohippocampal projections (Bpc -> PaS)
		FMM.NC.PH.PRS	Presubiculum	nucleus-neocortex	Detailed amygdalohippocampal projections (Bpc -> PrS)
LAC	FAM.FT.AM.BP	LAC.FD.HT.DM	Dorsomedial Hypothalamic Nucleus	nucleus-nucleus	Role for serotonin in moral behavior (AMY -> HYP, abstract)
		LAC.FD.HT.LTN	Lateral Hypothalamic Nucleus	nucleus-nucleus	Amygdala and its network (BLN -> HTS)
		LAC.FD.HT.PN	Posterior Hypothalamic Nucleus	nucleus-nucleus	Role for serotonin in moral behavior (AMY -> HYP, abstract)
LMC	FAM.FT.AM.BP	LMC.FT.NBM	Basal Nucleus of Meynert	nucleus-nucleus	(unknown reference)

Conditional Context Sensory Data and Memory Attention

Component ID	Component Name	Type	Service	Function	Comments
FAM.FD.TH.PT	Paratenial Nucleus of Thalamus	nucleus	FAU	Gateway for multimodal information to limbic system used in selecting appropriate responses	Projects to BNST, AM, OMPFC, ET; Direct behavior toward a particular outcome over a range of outcomes
FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	nucleus	FAU	enhance assotiative memory formation	proections to matrix of core of NACC
FAM.FT.AM.BM	Magnocellular Basal Amygdaloid Nucleus	nucleus	FAU	enhance emotional memories memories in medial prefrontal cortex
FAM.FT.AM.COA	Anterior Cortical Amygdaloid Nucleus	nucleus	FAU	olfactory processing - conditional contextual signaling
FAM.FT.AM.LADL	Dorsolateral Amygdaloid Nucleus	nucleus	FAU	conditional stimulus input - high-aggregated visual, auditory and somatic, patterns of perception	LA2

Internal Region Connections:

Source Region	Target Region	Type	Reference
FAM.FT.AM.COA	FAM.FT.AM.AB	nucleus-nucleus	(unknown reference)
FAM.FT.AM.LADL	FAM.FT.AM.AB	nucleus-nucleus	Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (L -> AB, abstract)

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NCP	FAM.FT.AM.BM	NCP.NC.INS.PIC	Posterior Insular Cortex	neocortex-nucleus	(unknown reference)
	FAM.FT.AM.LADL	NCP.NC.INS.PPC	Peripaleocortical Claustral	neocortex-nucleus	(unknown reference)
NDM	FAM.FT.AM.BM	NDM.NC.AL.FPC	Lateral Frontopolar Cortex	neocortex-nucleus	(unknown reference)
	FAM.FT.AM.LADL	NDM.NC.AL.VMPFC	Ventromedial Prefrontal Cortex	neocortex-nucleus	(unknown reference)
NSA	FAM.FT.AM.LADL	NSA.FD.TH.MGB	Medial Geniculate Body	nucleus-nucleus	Amygdalar disruption of prefrontal cortex (TH -> AM, abstract)
		NSA.NC.IT.TE	Inferotemporal Cortex	neocortex-nucleus	Amygdala and its network (ITC -> LA, abstract)
Subcortical
FAM	FAM.FT.AM.AB	FAM.FT.AM.LAVM	Ventromedial Amygdaloid Nucleus	nucleus-nucleus	Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (L -> AB, abstract)
	FAM.FT.AM.BM	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	nucleus-nucleus	(unknown reference)
	FAM.FT.AM.LADL	FAM.FT.IPAC.MED	Medial Interstitial Anterior Commissural Nucleus	nucleus-nucleus	(unknown reference)
FEC	FAM.FD.TH.PT	FEC.FT.VP.VM	Ventral Pallidum Ventromedial	nucleus-nucleus-gaba	Saccadic Vision (BG -> Thalamus, abstract)
FMM	FAM.FT.AM.AB	FMM.FT.HF.SUBD	Distal Subiculum	allocortex-nucleus	Simplified model of hippocampal formation anatomy (SUB -> Amyg, abstract)
		FMM.FT.HF.SUBP	Proximal Subiculum	allocortex-nucleus	Simplified model of hippocampal formation anatomy (SUB -> Amyg, abstract)
		FMM.NC.PH.LEC	Lateral Entorhinal Cortex	neocortex-nucleus	Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)
LAC	FAM.FD.TH.PT	LAC.FD.HT.PO	Preoptic Nucleus	nucleus-nucleus	(unknown reference)
LMC	FAM.FT.AM.BM	LMC.FT.NBM	Basal Nucleus of Meynert	nucleus-nucleus-ACh	(unknown reference)
LPC	FAM.FT.AM.COA	LPC.FT.MOB	Main Olfactory Bulb	nucleus-nucleus	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NCP	FAM.FD.TH.PT	NCP.NC.MPL.PSCG	Posterior Cingulate Cortex	nucleus-neocortex	Contributions of Diencephalon to Recognition Memory (MID -> PostCingulate, abstract)
		NCP.NC.MPL.RSC	Retrosplenial Cortex	nucleus-neocortex	(unknown reference)
	FAM.FT.AM.BM	NCP.NC.MPL.PSCG	Posterior Cingulate Cortex	nucleus-neocortex	Oculomotor decision-making (AMYG -> CGp, abstract)
NDM	FAM.FD.TH.PT	NDM.NC.AL.ROFCR	Most Rostral Orbitofrontal Cortex	nucleus-neocortex	Saccadic Vision (Thalamus -> FrontalCortex, abstract)
	FAM.FT.AM.AB	NDM.FD.TH.MDM	Medial Mediodorsal Nucleus of Thalamus	nucleus-nucleus	Prefrontal Cortex (PFC) in emotional behavior (AM -> TH, abstract)
		NDM.NC.AL.DACG	Dorsal Anterior Cingulate Area	nucleus-neocortex	Amygdalar disruption of prefrontal cortex (AM -> ACG, abstract)
		NDM.NC.AL.VACG	Ventral Anterior Cingulate Area	nucleus-neocortex	Amygdalar disruption of prefrontal cortex (AM -> ACG, abstract)
NPE	FAM.FD.TH.PT	NPE.FD.TH.MPV	Medial Pulvinar	nucleus-nucleus	Contributions of Diencephalon to Recognition Memory (MID -> mPULV, abstract)
NSA	FAM.FT.AM.BM	NSA.NC.TTG.A1	Primary Auditory Cortex	nucleus-neocortex	Visual-Auditory Interactions in Tectum (AM -> AC, abstract)
Subcortical
FAM	FAM.FD.TH.PT	FAM.FT.AM.LAVL	Ventrolateral Amygdaloid Nucleus	nucleus-nucleus	Amygdalar disruption of prefrontal cortex (TH -> AM, abstract)
		FAM.FT.BNST	Bed Nucleus of Stria Terminalis	nucleus-nucleus	(unknown reference)
	FAM.FT.AM.AB	FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	nucleus-nucleus	Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (AB -> CE, abstract)
		FAM.FT.AM.MPD	Medial Posterior Dorsal Amygdaloid Nucleus	nucleus-nucleus	Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (AB -> M, abstract)
	FAM.FT.AM.BM	FAM.FT.AM.ITC	Intercalated Amygdaloid Nuclei	nucleus-nucleus	(unknown reference)
	FAM.FT.AM.LADL	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	nucleus-nucleus	Amygdala and its network (LA -> BLN, abstract)
		FAM.FT.AM.CEC	Central Amygdaloid Nucleus, capsular subdivision	nucleus-nucleus	Amygdala and its network (LA -> CEA, abstract)
		FAM.FT.AM.ITC	Intercalated Amygdaloid Nuclei	nucleus-nucleus	(unknown reference)
		FAM.FT.AM.LAVM	Ventromedial Amygdaloid Nucleus	nucleus-nucleus	(unknown reference)
FEC	FAM.FD.TH.PT	FEC.FT.ACC.CORE	Nucleus Accumbens Core	nucleus-nucleus	(unknown reference)
	FAM.FT.AM.AB	FEC.FT.CN.TL	Caudate Nucleus Tail	nucleus-nucleus	(unknown reference)
FMM	FAM.FD.TH.PT	FMM.NC.PH.LEC	Lateral Entorhinal Cortex	nucleus-neocortex	Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)
	FAM.FT.AM.AB	FMM.FT.HC.CA1P	Proximal CA1 of Hippocampus	nucleus-allocortex	Detailed amygdalohippocampal projections (ABmg -> CA1P)
LMC	FAM.FT.AM.AB	LMC.FT.NBM	Basal Nucleus of Meynert	nucleus-nucleus	(unknown reference)

Express Flight Emotions

Component ID	Component Name	Type	Service	Function	Comments
FAM.FT.AM.MEA	Medial Anterior Amygdaloid Nucleus	nucleus	FAU	olfactory processing
FAM.FT.AM.MPD	Medial Posterior Dorsal Amygdaloid Nucleus	nucleus	FAU	reproductive behavior	MePD -> HT-MPN
FAM.FT.AM.MPV	Medial Posterior Ventral Amygdaloid Nucleus	nucleus	FAU	defensive behavior	MePV -> LAC.FD.HT.VM (reproductive+defensive), LAC.FD.HT.AH (defensive)
FAM.FT.BNST	Bed Nucleus of Stria Terminalis	nucleus	FAU	Mediate slow longer-lasting responses that accompany sustained threats	Major output from AM to HT, part of extended amygdala; medial part continues to medial AM, central part continues to central AM
FAM.FT.IPAC.MED	Medial Interstitial Anterior Commissural Nucleus	nucleus	FAU	Sharp, acute pain sensation	reciprocate its afferent connections, similar to medial part of central amygdaloid nucleus; projections to AM-Ce/BNST components, PB, and SOL originate chiefly from medial division; strong ACh projections from caudal IPACm to AM-BL-posterior and amygdalopiriform transition area
FAM.FT.SEP.BAC	Bed Nucleus of Anterior Commissure	nucleus	FAU	projection to contralateral HC

Internal Region Connections:

Source Region	Target Region	Type	Reference
FAM.FT.AM.MEA	FAM.FT.AM.MPD	nucleus-nucleus	(unknown reference)
	FAM.FT.AM.MPV	nucleus-nucleus	(unknown reference)
	FAM.FT.BNST	nucleus-nucleus	(unknown reference)
	FAM.FT.IPAC.MED	nucleus-nucleus	(unknown reference)
FAM.FT.AM.MPV	FAM.FT.BNST	nucleus-nucleus-gaba	(unknown reference)
FAM.FT.BNST	FAM.FT.IPAC.MED	nucleus-nucleus	(unknown reference)
	FAM.FT.SEP.BAC	nucleus-nucleus	(unknown reference)

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NCP	FAM.FT.BNST	NCP.NC.AL.SGCG	Subgenual Cingulate Cortex	neocortex-nucleus	(unknown reference)
NSA	FAM.FT.IPAC.MED	NSA.NC.PH.PIR	Piriform Cortex	neocortex-nucleus	(unknown reference)
Subcortical
FAM	FAM.FT.AM.MEA	FAM.FT.AM.COP	Posterior Cortical Amygdaloid Nucleus	nucleus-nucleus	(unknown reference)
	FAM.FT.AM.MPD	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	nucleus-nucleus	Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (AB -> M, abstract)
	FAM.FT.AM.MPV	FAM.FT.AM.LAVM	Ventromedial Amygdaloid Nucleus	nucleus-nucleus	Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (L -> M, abstract)
	FAM.FT.BNST	FAM.FD.TH.PT	Paratenial Nucleus of Thalamus	nucleus-nucleus	(unknown reference)
		FAM.FT.AM.CEL	Central Amygdaloid Nucleus, lateral subdivision	nucleus-nucleus	(unknown reference)
LAC	FAM.FT.BNST	LAC.FD.HT.VM	Ventromedial Hypothalamic Nucleus	nucleus-nucleus	(unknown reference)
LPC	FAM.FT.AM.MEA	LPC.FT.AOB	Accessory Olfactory Bulb	nucleus-nucleus	(unknown reference)
	FAM.FT.BNST	LPC.FD.TH.PV	Paraventricular Nucleus of Thalamus	nucleus-nucleus	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Subcortical
FAM	FAM.FT.AM.MEA	FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	nucleus-nucleus	Body alarm system (MED -> CE, abstract)
	FAM.FT.AM.MPV	FAM.FT.SEP.LT	Lateral Septal Nucleus	nucleus-nucleus-gaba	(unknown reference)
	FAM.FT.IPAC.MED	FAM.FT.AM.LADL	Dorsolateral Amygdaloid Nucleus	nucleus-nucleus	(unknown reference)
	FAM.FT.SEP.BAC	FAM.FD.MHB	Medial Habenula	nucleus-nucleus	Connectivity map of the habenula (Septum -> M, abstract)
FEC	FAM.FT.BNST	FEC.FT.SNC.MED	Substantia Nigra Pars Compacta Medial	nucleus-nucleus	(unknown reference)
FMM	FAM.FT.AM.MPV	FMM.FD.TH.RE	Reuniens Nucleus of Thalamus	nucleus-nucleus-gaba	Oculomotor decision-making (AMYG -> Thalamus, abstract)
	FAM.FT.SEP.BAC	FMM.FT.HF.SUBP	Proximal Subiculum	nucleus-allocortex	Medial mammillary nucleus and theta rhythm (SEP -> HF, abstract)
LAC	FAM.FT.AM.MEA	LAC.FD.HT.PO	Preoptic Nucleus	nucleus-nucleus	Role for serotonin in moral behavior (AMY -> HYP, abstract)
	FAM.FT.AM.MPD	LAC.FD.HT.PO	Preoptic Nucleus	nucleus-nucleus-gaba	Role for serotonin in moral behavior (AMY -> HYP, abstract)
		LAC.FD.HT.PV	Paraventricular Nucleus	nucleus-nucleus-gaba	Amygdalar disruption of prefrontal cortex (AM -> HT.PV, abstract)
	FAM.FT.AM.MPV	LAC.FD.HT.PRM	Premammillary Nucleus	nucleus-nucleus-gaba	Amygdalar disruption of prefrontal cortex (AM -> HT.L, abstract)
		LAC.FD.HT.VM	Ventromedial Hypothalamic Nucleus	nucleus-nucleus-gaba	Role for serotonin in moral behavior (AMY -> HYP, abstract)
LMC	FAM.FT.BNST	LMC.FT.NBM	Basal Nucleus of Meynert	nucleus-nucleus	(unknown reference)
		LMC.HT.LC	Locus Coeruleus	nucleus-nucleus	(unknown reference)
		LMC.MM.VTA	Ventral Tegmental Area	nucleus-nucleus	(unknown reference)
LPC	FAM.FT.IPAC.MED	LPC.HL.SOL	Solitary Nucleus	nucleus-nucleus	(unknown reference)
		LPC.HT.PRF.PB	Parabrachial Nucleus	nucleus-nucleus	(unknown reference)

Express Fight Emotions

Component ID	Component Name	Type	Service	Function	Comments
FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	nucleus	FAU	mediate behavioral responses, output projections
FAM.FT.SEP.SH	Septohippocampal Nucleus	nucleus	FAU	participate in solving conflict between two or more competing goals, defensive circuit

Internal Region Connections:

• no connections

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NDM	FAM.FT.SEP.SH	NDM.NC.AL.FPC	Lateral Frontopolar Cortex	neocortex-nucleus	(unknown reference)
Subcortical
FAM	FAM.FT.AM.CEM	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	nucleus-nucleus	Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (AB -> CE, abstract)
		FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	nucleus-nucleus	Amygdala and its network (BLN -> CEA, abstract)
		FAM.FT.AM.CEC	Central Amygdaloid Nucleus, capsular subdivision	nucleus-nucleus	(unknown reference)
		FAM.FT.AM.CEL	Central Amygdaloid Nucleus, lateral subdivision	nucleus-nucleus	(unknown reference)
		FAM.FT.AM.ITC	Intercalated Amygdaloid Nuclei	nucleus-nucleus-gaba	(unknown reference)
		FAM.FT.AM.MEA	Medial Anterior Amygdaloid Nucleus	nucleus-nucleus	Body alarm system (MED -> CE, abstract)
FEC	FAM.FT.AM.CEM	FEC.FT.SNC.MED	Substantia Nigra Pars Compacta Medial	nucleus-nucleus-DA	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Subcortical
FAM	FAM.FT.AM.CEM	FAM.FT.SEP.LT	Lateral Septal Nucleus	nucleus-nucleus	(unknown reference)
LAC	FAM.FT.AM.CEM	LAC.FD.HT.LTN	Lateral Hypothalamic Nucleus	nucleus-nucleus	Amygdalar disruption of prefrontal cortex (AM -> HT.L, abstract)
		LAC.HL.VGN	Vagus Nucleus	nucleus-nucleus	Amygdala and its network (CEA -> VGDM, abstract)
	FAM.FT.SEP.SH	LAC.FD.HT.LTN	Lateral Hypothalamic Nucleus	nucleus-nucleus	Cingulate Gyrus (SEP -> HT, abstract)
LMC	FAM.FT.AM.CEM	LMC.FT.NBM	Basal Nucleus of Meynert	nucleus-nucleus	(unknown reference)
		LMC.HT.LC	Locus Coeruleus	nucleus-nucleus	Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)
		LMC.MM.PAG	Periaqueductal Gray Matter	nucleus-nucleus	Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)

Solving Fight-Flight Dilemma

Component ID	Component Name	Type	Service	Function	Comments
FAM.FT.SEP.LT	Lateral Septal Nucleus	nucleus	FAU	promote active stress coping behavior

Internal Region Connections:

• no connections

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Subcortical
FAM	FAM.FT.SEP.LT	FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	nucleus-nucleus	(unknown reference)
		FAM.FT.AM.MPV	Medial Posterior Ventral Amygdaloid Nucleus	nucleus-nucleus-gaba	(unknown reference)
FMM	FAM.FT.SEP.LT	FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	allocortex-nucleus	Connectivity map of the habenula (Hippo -> Septum, abstract)
LAC	FAM.FT.SEP.LT	LAC.FD.HT.PN	Posterior Hypothalamic Nucleus	nucleus-nucleus	(unknown reference)
		LAC.FD.HT.TBM	Tuberomammillary Nucleus	nucleus-nucleus	(unknown reference)
LMC	FAM.FT.SEP.LT	LMC.MM.RF.SUC	Superior Central Raphe Nucleus	nucleus-nucleus-5HT	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Subcortical
FAM	FAM.FT.SEP.LT	FAM.FD.LHB.MED	Lateral Habenula Medial Part	nucleus-nucleus-gaba	Both LHb and MHb control the dopaminergic and serotonergic systems (LS -> LHbM)
LAC	FAM.FT.SEP.LT	LAC.FD.HT.PO	Preoptic Nucleus	nucleus-nucleus-gaba	Cingulate Gyrus (SEP -> HT, abstract)
LPC	FAM.FT.SEP.LT	LPC.FD.TH.PV	Paraventricular Nucleus of Thalamus	nucleus-nucleus-gaba	(unknown reference)

Memory Formation Affective Focus

Component ID	Component Name	Type	Service	Function	Comments
FAM.FT.SEP.DBB	Diagonal Band of Broca	nucleus	FAU	involved in generation of theta waves in hippocampus	ACh and GABA; ventral group - from stria terminalis to/from MFB
FAM.FT.SEP.MED	Medial Septal Nucleus	nucleus	FAU	affect HC for spatial learning, generation of theta waves	output nucleus; projections from AM and HC overlap; control theta rythm and exprolatory behavior; from/to MFB to fornix fimbria

Internal Region Connections:

• no connections

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Subcortical
LAC	FAM.FT.SEP.DBB	LAC.FD.HT.SUM	Supramammillary Nucleus	nucleus-nucleus	Medial mammillary nucleus and theta rhythm (SupraMM -> SEP, abstract)
	FAM.FT.SEP.MED	LAC.FD.HT.SUM	Supramammillary Nucleus	nucleus-nucleus	Medial mammillary nucleus and theta rhythm (SupraMM -> SEP, abstract)
LMC	FAM.FT.SEP.DBB	LMC.HT.LC	Locus Coeruleus	nucleus-nucleus-NE	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NCP	FAM.FT.SEP.MED	NCP.NC.MPL.RSC	Retrosplenial Cortex	nucleus-neocortex-ACh	Medial mammillary nucleus and theta rhythm (SEP -> RSP, abstract)
NDM	FAM.FT.SEP.DBB	NDM.NC.AL.VMPFC	Ventromedial Prefrontal Cortex	nucleus-neocortex-gaba	(unknown reference)
	FAM.FT.SEP.MED	NDM.FD.TH.MDM	Medial Mediodorsal Nucleus of Thalamus	nucleus-nucleus-ACh	Thalamocortical relationships (s1MD -> MD, abstract)
Subcortical
FAM	FAM.FT.SEP.DBB	FAM.FD.LHB.MED	Lateral Habenula Medial Part	nucleus-nucleus-gaba	Both LHb and MHb control the dopaminergic and serotonergic systems (DBB -> LHbM)
		FAM.FD.MHB	Medial Habenula	nucleus-nucleus-gaba	Habenula Connections (DBB -> MHb)
	FAM.FT.SEP.MED	FAM.FD.MHB	Medial Habenula	nucleus-nucleus-ACh	Both LHb and MHb control the dopaminergic and serotonergic systems (MS -> MHb)
FEC	FAM.FT.SEP.MED	FEC.FD.TH.PF	Parafascicular Nucleus of Thalamus	nucleus-nucleus-ACh	(unknown reference)
FMM	FAM.FT.SEP.DBB	FMM.FD.MB.MMB	Medial Mammillary Nucleus	nucleus-nucleus-gaba	Cingulate Gyrus (SEP -> HT, abstract)
		FMM.FT.HC.CA2	Dorsolateral Cornu Ammonis of Hippocampus	nucleus-allocortex-gaba	Medial mammillary nucleus and theta rhythm (SEP -> HF, abstract)
	FAM.FT.SEP.MED	FMM.FD.MB.LMB	Lateral Mammillary Nucleus	nucleus-nucleus-ACh	Cingulate Gyrus (SEP -> HT, abstract)
		FMM.FD.MB.MMB	Medial Mammillary Nucleus	nucleus-nucleus-gaba	Cingulate Gyrus (SEP -> HT, abstract)

Reward Emotions Control

Component ID	Component Name	Type	Service	Function	Comments
FAM.FD.MHB	Medial Habenula	nucleus	FAU	Encoding negative feedback, indirect	affects VTA, dorsal raphe but via interpeduncular nucleus
FAM.FT.EPF	Endopiriform Nucleus	nucleus	FAU	Putative relay of limbic-associated cortical-like areas subserving affective information
FAM.HT.TG.NI	Incertus Nucleus	nucleus	LUS	Behavioural activation and the response to stress	Modulating influences on prefrontal and hippocampal cortical activity, midline behavior control; modulatory nucleus; relay from reticularis pontis oralis nucleus to septo-hippocampal system

Internal Region Connections:

Source Region	Target Region	Type	Reference
FAM.HT.TG.NI	FAM.FT.EPF	nucleus-nucleus-gaba	(unknown reference)

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NSA	FAM.FT.EPF	NSA.NC.PH.PIR	Piriform Cortex	neocortex-nucleus	Gustatory sensory system of rat and macaque (PiR -> EnP)
Subcortical
FAM	FAM.FD.MHB	FAM.FT.SEP.BAC	Bed Nucleus of Anterior Commissure	nucleus-nucleus	Connectivity map of the habenula (Septum -> M, abstract)
		FAM.FT.SEP.DBB	Diagonal Band of Broca	nucleus-nucleus-gaba	Habenula Connections (DBB -> MHb)
		FAM.FT.SEP.MED	Medial Septal Nucleus	nucleus-nucleus-ACh	Both LHb and MHb control the dopaminergic and serotonergic systems (MS -> MHb)
		FAM.FT.SEP.SF	Septofimbrial Nucleus	nucleus-nucleus-gaba	Connectivity map of the habenula (Septum -> M, abstract)
		FAM.FT.SEP.TR	Triangular Septal Nucleus	nucleus-nucleus-gaba	Connectivity map of the habenula (Septum -> M, abstract)
	FAM.HT.TG.NI	FAM.FD.LHB.MED	Lateral Habenula Medial Part	nucleus-nucleus	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> NI)
FEC	FAM.FD.MHB	FEC.FT.ACC.SH	Nucleus Accumbens Shell	nucleus-nucleus-gaba	Connectivity map of the habenula (NAc -> M, abstract)
	FAM.FT.EPF	FEC.FT.PU.VT	Ventral Putamen	nucleus-nucleus-gaba	Connectivity map of the habenula (CPu -> EP, abstract)
LMC	FAM.FD.MHB	LMC.HT.LC	Locus Coeruleus	nucleus-nucleus-NE	(unknown reference)
LRC	FAM.HT.TG.NI	LRC.HT.PRF.RPO	Oral Pontine Reticular Nucleus	nucleus-nucleus	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Cortical
NCP	FAM.FT.EPF	NCP.NC.INS.AIC	Anterior Insular Cortex	nucleus-neocortex	Gustatory sensory system of rat and macaque (EnP -> Iav, abstract)
Subcortical
FAM	FAM.FD.MHB	FAM.FD.LHB.MED	Lateral Habenula Medial Part	nucleus-nucleus	Connectivity map of the habenula (M -> L, abstract)
	FAM.FT.EPF	FAM.FD.LHB.LT	Lateral Habenula Lateral Part	nucleus-nucleus	Regulation of the rapid eye movement (REM) sleep by habenular projection (EPN -> LHbL)
	FAM.HT.TG.NI	FAM.FT.SEP.SF	Septofimbrial Nucleus	nucleus-nucleus-gaba	(unknown reference)
		FAM.FT.SEP.TR	Triangular Septal Nucleus	nucleus-nucleus-gaba	(unknown reference)
FEC	FAM.FD.MHB	FEC.HT.PPN.IPD	Interpeduncular Nucleus	nucleus-nucleus	Connectivity map of the habenula (M -> IPN)
FMM	FAM.HT.TG.NI	FMM.NC.PH.PER	Perirhinal Cortex	nucleus-neocortex-gaba	(unknown reference)
Target
TEA	FAM.FD.MHB	TARGET.TEA.ENDOCRINE	Endocrine Glands	endocrine-pineal-gland	Habenula Connections (MHb -> PB)

Fast Unconditional Sensory Data and Association Memory

Component ID	Component Name	Type	Service	Function	Comments
FAM.FT.AM.CEC	Central Amygdaloid Nucleus, capsular subdivision	nucleus	FAU	mediate behavioral responses, link to striatal effect	gustatory, somatosensory, visual, auditory, frontal cortex, perirhinal cortex, ET, SUB -> X -> HT-dl/cl, CeM
FAM.FT.AM.CEL	Central Amygdaloid Nucleus, lateral subdivision	nucleus	FAU	mediate behavioral responses, link to gustatory and visceral aspects of reinforcement	contributions of food prediction and food presentation
FAM.FT.AM.COP	Posterior Cortical Amygdaloid Nucleus	nucleus	FAU	olfactory processing - unconditional signaling
FAM.FT.AM.LAVL	Ventrolateral Amygdaloid Nucleus	nucleus	FAU	unconditional stimulus input - visual, auditory and somatic, convergence from thalamus	LA1; LGN, MGBm, PIL
FAM.FT.AM.LAVM	Ventromedial Amygdaloid Nucleus	nucleus	FAU	conditional and unconditional convergence to affect polymodal memory formation	LA3; projects to ET

Internal Region Connections:

• no connections

External Inbound Region Connections:

Source Area	Local Region	Source Region	Source Name	Type	Reference
Cortical
NSA	FAM.FT.AM.CEL	NSA.NC.PO.PCC	Precentral Cortex	neocortex-nucleus	(unknown reference)
	FAM.FT.AM.LAVL	NSA.FD.TH.SG	Suprageniculate Nucleus of Thalamus	nucleus-nucleus	Amygdalar disruption of prefrontal cortex (TH -> AM, abstract)
	FAM.FT.AM.LAVM	NSA.NC.STG.A3	Wernicke's area A3	neocortex-nucleus	Amygdala and its network (STC -> LA, abstract)
Subcortical
FAM	FAM.FT.AM.CEC	FAM.FT.AM.LADL	Dorsolateral Amygdaloid Nucleus	nucleus-nucleus	Amygdala and its network (LA -> CEA, abstract)
	FAM.FT.AM.LAVL	FAM.FD.TH.PT	Paratenial Nucleus of Thalamus	nucleus-nucleus	Amygdalar disruption of prefrontal cortex (TH -> AM, abstract)
	FAM.FT.AM.LAVM	FAM.FT.AM.LADL	Dorsolateral Amygdaloid Nucleus	nucleus-nucleus	(unknown reference)
FMM	FAM.FT.AM.LAVM	FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	allocortex-nucleus	Fear regulation (Hippocampus -> LA, abstract)
		FMM.NC.PH.LEC	Lateral Entorhinal Cortex	neocortex-nucleus	Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)
LMC	FAM.FT.AM.CEC	LMC.MM.VTA	Ventral Tegmental Area	nucleus-nucleus-DA	Reward circuit of human brain (VTA -> AM, abstract)
LPC	FAM.FT.AM.CEL	LPC.HT.PRF.PB	Parabrachial Nucleus	nucleus-nucleus	Amygdalar disruption of prefrontal cortex (PB -> AM, abstract)
	FAM.FT.AM.COP	LPC.FT.AOB	Accessory Olfactory Bulb	nucleus-nucleus	(unknown reference)

External Outbound Region Connections:

Target Area	Local Region	Target Region	Target Name	Type	Reference
Subcortical
FAM	FAM.FT.AM.CEC	FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	nucleus-nucleus	(unknown reference)
	FAM.FT.AM.CEL	FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	nucleus-nucleus	(unknown reference)
		FAM.FT.BNST	Bed Nucleus of Stria Terminalis	nucleus-nucleus	(unknown reference)
	FAM.FT.AM.COP	FAM.FT.AM.MEA	Medial Anterior Amygdaloid Nucleus	nucleus-nucleus	(unknown reference)
	FAM.FT.AM.LAVL	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	nucleus-nucleus	Amygdala and its network (LA -> BLN, abstract)
	FAM.FT.AM.LAVM	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	nucleus-nucleus	Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (L -> AB, abstract)
		FAM.FT.AM.MPV	Medial Posterior Ventral Amygdaloid Nucleus	nucleus-nucleus	Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (L -> M, abstract)
FMM	FAM.FT.AM.LAVL	FMM.NC.PH.PAS	Parasubiculum	nucleus-neocortex	Detailed amygdalohippocampal projections (L -> PaS, abstract)
LAC	FAM.FT.AM.COP	LAC.FD.HT.SO	Supraoptic Nucleus	nucleus-nucleus	Role for serotonin in moral behavior (AMY -> HYP, abstract)
LPC	FAM.FT.AM.CEL	LPC.HL.SOL	Solitary Nucleus	nucleus-nucleus	(unknown reference)
	FAM.FT.AM.LAVM	LPC.FD.TH.PV	Paraventricular Nucleus of Thalamus	nucleus-nucleus	Oculomotor decision-making (AMYG -> Thalamus, abstract)
		LPC.MM.CIC	Central Nucleus of Inferior Colliculus	nucleus-nucleus	Visual-Auditory Interactions in Tectum (AM -> IC, abstract)

Thirdparty Circuits

(generated)

• Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference

• Regulation of the rapid eye movement (REM) sleep by habenular projection - see Reference

• Body alarm system - see Reference

• Detailed amygdalohippocampal projections - see Reference

• Habenula Connections - see Reference

• Connectivity map of the habenula - see Reference

• Gustatory sensory system of rat and macaque - see Reference

• Medial prefrontal network - see Reference

• Fear regulation - see Reference

• Amygdala and its network - see Reference

• Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat - see Reference

• Dorsal midline thalamus - see Reference

• Exploring role of habenula in emotional behaviors - see Reference

• Connectivity of dorsal diencephalic conduction system - see Reference

References

(generated)

• http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html
• http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full
• http://thebrain.mcgill.ca/flash/i/i_04/i_04_cl/i_04_cl_peu/i_04_cl_peu.html
• https://books.google.ru/books?id=P3fSBwAAQBAJ
• http://www.scholarpedia.org/article/Habenula
• http://jn.physiology.org/content/107/10/2633
• http://www.sciencedirect.com/science/article/pii/S0149763401000215
• http://www.nature.com/npp/journal/v35/n1/fig_tab/npp2009104f10.html
• https://brmlab.cz/project/brain_hacking/tdcs/pfc
• http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin
• http://journal.frontiersin.org/article/10.3389/fphar.2014.00068/full
• http://www.sciencedirect.com/science/article/pii/S0149763415002055
• http://dgr.brain.riken.jp/AsymmetryE.html
• http://rstb.royalsocietypublishing.org/content/364/1519/1005