Difference between revisions of "BrainAreaFEC"
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<img src="http://www.scholarpedia.org/w/images/6/63/Taube_Figure_5a.png" alt="unavailable" style="max-width: 100%;"> | <img src="http://www.scholarpedia.org/w/images/6/63/Taube_Figure_5a.png" alt="unavailable" style="max-width: 100%;"> | ||
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| + | * [http://www.nature.com/nrn/journal/v11/n6/images/nrn2849-f7.jpg Contribution of nAChR subunits to nicotine withdrawal symptoms] - see [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Reference] | ||
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| + | <img src="http://www.nature.com/nrn/journal/v11/n6/images/nrn2849-f7.jpg" alt="unavailable" style="max-width: 100%;"> | ||
* [http://d2avczb82rh8fa.cloudfront.net/content/jn/107/10/2633/F1.large.jpg Connectivity map of the habenula] - see [http://jn.physiology.org/content/107/10/2633 Reference] | * [http://d2avczb82rh8fa.cloudfront.net/content/jn/107/10/2633/F1.large.jpg Connectivity map of the habenula] - see [http://jn.physiology.org/content/107/10/2633 Reference] | ||
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* http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin | * http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin | ||
* http://www.scholarpedia.org/article/Head_direction_cells | * http://www.scholarpedia.org/article/Head_direction_cells | ||
| + | * http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html | ||
* http://jn.physiology.org/content/107/10/2633 | * http://jn.physiology.org/content/107/10/2633 | ||
* http://rstb.royalsocietypublishing.org/content/364/1519/1005 | * http://rstb.royalsocietypublishing.org/content/364/1519/1005 | ||
Revision as of 08:57, 1 September 2015
Forebrain Execution Control Area
Home -> BiologicalLifeResearch -> BrainAreaFEC
Contents
Local Circuits
(generated)
| ID | Name | Regions |
| FECAF | Cognitive Motivational Salience | FEC.FD.STN.DL, FEC.FT.ACC.SH, FEC.FT.GPE.RM, FEC.FT.GPI.RM, FEC.FT.VP.VM |
| FECEXE | Executive/Cognitive Loop | FEC.FD.STN.CD, FEC.FT.CN.HD, FEC.FT.GPE.DS, FEC.FT.GPI.DS, FEC.FT.SNC.LT, FEC.FT.SNR.RM |
| FECLM | Motor Motivational Salience | FEC.FT.ACC.CORE, FEC.FT.CN.TL, FEC.FT.IPAC.LT, FEC.FT.PU.VT, FEC.FT.SNC.MED, FEC.FT.SNR.MED, FEC.FT.VP.DL |
| FECME | Motor Extensor Loop | FEC.FD.STN.MED, FEC.FD.TH.PF, FEC.FT.GPE.MED, FEC.FT.GPI.MED, FEC.FT.PU.MED, FEC.FT.SNR.DL |
| FECMF | Motor Flexor Loop | FEC.FD.STN.LT, FEC.FD.TH.CM, FEC.FD.TH.RIL, FEC.FT.GPE.LT, FEC.FT.GPI.LT, FEC.FT.PU.LT, FEC.HT.PPN.IPD, FEC.HT.PPN.RMTG |
| FECOM | Oculomotor and Auditory/Association Loop | FEC.FD.STN.ICD, FEC.FD.TH.LI, FEC.FT.CN.BD, FEC.FT.GPE.DL, FEC.FT.GPI.DL, FEC.FT.SNR.VL |
Cognitive Motivational Salience
| Component ID | Component Name | Type | Service | Function | Comments |
| FEC.FD.STN.DL | Subthalamic Nucleus Dorsolateral | nucleus | FEU | Motivational loop | |
| FEC.FT.ACC.SH | Nucleus Accumbens Shell | nucleus | FEU | cognitive processing of motivational salience (wanting) as well as reward and reinforcement effects |
|
| FEC.FT.GPE.RM | Globus Pallidus External Rostromedial | nucleus | FEU | Motivational loop | |
| FEC.FT.GPI.RM | Globus Pallidus Internal Rostromedial | nucleus | FEU | Motivational loop | |
| FEC.FT.VP.VM | Ventral Pallidum Ventromedial | nucleus | FEU | motivational loop, NAcc-shell | projects to VTA, MD; circuit - VP-VM-medial, VMPFC, NAcc-medial-shell, MD-rostral-medial; circuit - VP-VM-lateral, VINS, NAcc-VL, MD-central |
Internal Region Connections:
| Source Region | Target Region | Type | Reference |
| FEC.FD.STN.DL | FEC.FT.GPE.RM | nucleus-nucleus | (unknown reference) |
| FEC.FT.GPI.RM | nucleus-nucleus | Basal Ganglia Activity (STN -> GPi, abstract) | |
| FEC.FT.ACC.SH | FEC.FT.VP.VM | nucleus-nucleus-gaba | Craving (NACC -> VPAL, abstract) |
| FEC.FT.GPE.RM | FEC.FT.GPI.RM | nucleus-nucleus-gaba | (unknown reference) |
External Inbound Region Connections:
| Source Area | Local Region | Source Region | Source Name | Type | Reference |
| Cortical | |||||
| NCP | FEC.FT.ACC.SH | NCP.NC.MPL.PSCG | Posterior Cingulate Cortex | neocortex-nucleus | (unknown reference) |
| NDM | FEC.FD.STN.DL | NDM.NC.AL.ROFCR | Most Rostral Orbitofrontal Cortex | neocortex-nucleus | (unknown reference) |
| FEC.FT.ACC.SH | NDM.NC.AL.VACG | Ventral Anterior Cingulate Area | neocortex-nucleus | Global visual system (FrontalCortex -> BGA, abstract) | |
| Subcortical | |||||
| FEC | FEC.FT.ACC.SH | FEC.FT.SNC.LT | Substantia Nigra Pars Compacta Lateral | nucleus-nucleus-DA | Connectivity map of the habenula (SNc -> CPu, abstract) |
| FEC.FT.SNC.MED | Substantia Nigra Pars Compacta Medial | nucleus-nucleus-DA | Connectivity map of the habenula (SNc -> CPu, abstract) | ||
| FEC.FT.GPI.RM | FEC.FT.CN.TL | Caudate Nucleus Tail | nucleus-nucleus-gaba | Habenula Connections (CPu -> GPi, abstract) | |
| FEC.FT.VP.VM | FEC.FT.IPAC.LT | Lateral Interstitial Anterior Commissural Nucleus | nucleus-nucleus-gaba | (unknown reference) | |
| LMC | FEC.FT.ACC.SH | LMC.MM.VTA | Ventral Tegmental Area | nucleus-nucleus-DA | Craving (VTA -> NACC, abstract) |
External Outbound Region Connections:
| Target Area | Local Region | Target Region | Target Name | Type | Reference |
| Cortical | |||||
| NCP | FEC.FT.VP.VM | NCP.FD.TH.MDC | Central Mediodorsal Nucleus of Thalamus | nucleus-nucleus-gaba | Saccadic Vision (BG -> Thalamus, abstract) |
| NDM | FEC.FT.GPI.RM | NDM.FD.TH.MDM | Medial Mediodorsal Nucleus of Thalamus | nucleus-nucleus-gaba | Saccadic Vision (BG -> Thalamus, abstract) |
| Subcortical | |||||
| FAM | FEC.FT.ACC.SH | FAM.FD.MHB | Medial Habenula | nucleus-nucleus-gaba | Connectivity map of the habenula (NAc -> M, abstract) |
| FEC.FT.VP.VM | FAM.FD.LHB.MED | Lateral Habenula Medial Part | nucleus-nucleus-gaba | Both LHb and MHb control the dopaminergic and serotonergic systems (VP -> LHbM, abstract) | |
| FAM.FD.TH.PT | Paratenial Nucleus of Thalamus | nucleus-nucleus-gaba | Saccadic Vision (BG -> Thalamus, abstract) | ||
| FEC | FEC.FD.STN.DL | FEC.FT.PU.VT | Ventral Putamen | nucleus-nucleus | (unknown reference) |
| FEC.FT.SNR.MED | Substantia Nigra Pars Reticulata Medial | nucleus-nucleus | (unknown reference) | ||
| FEC.FT.ACC.SH | FEC.FT.IPAC.LT | Lateral Interstitial Anterior Commissural Nucleus | nucleus-nucleus-gaba | (unknown reference) | |
| FEC.FT.GPE.RM | FEC.FT.SNR.MED | Substantia Nigra Pars Reticulata Medial | nucleus-nucleus-gaba | Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract) | |
| FEC.FT.GPI.RM | FEC.FT.SNC.MED | Substantia Nigra Pars Compacta Medial | nucleus-nucleus-gaba | Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract) | |
| FEC.FT.VP.VM | FEC.HT.PPN.RMTG | Rostromedial Tegmental Nucleus | nucleus-nucleus-gaba | Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VPAL -> PPTG, abstract) | |
| LAC | FEC.FT.ACC.SH | LAC.FD.HT.LTN | Lateral Hypothalamic Nucleus | nucleus-nucleus-gaba | (unknown reference) |
| LMC | FEC.FT.ACC.SH | LMC.FT.NBM | Basal Nucleus of Meynert | nucleus-nucleus-gaba | Affective basal ganglia circuit (NACC -> nBM, abstract) |
| FEC.FT.VP.VM | LMC.MM.VTA | Ventral Tegmental Area | nucleus-nucleus-gaba | Craving (VPAL -> VTA, abstract) |
Executive/Cognitive Loop
| Component ID | Component Name | Type | Service | Function | Comments |
| FEC.FD.STN.CD | Subthalamic Nucleus Caudal | nucleus | FEU | Executive loop | |
| FEC.FT.CN.HD | Caudate Nucleus Head | nucleus | FEU | Feedback processing, result of incorrect categorization | LPFC, BA 9 |
| FEC.FT.GPE.DS | Globus Pallidus External Dorsal | nucleus | FEU | Executive loop | |
| FEC.FT.GPI.DS | Globus Pallidus Internal Dorsal | nucleus | FEU | Executive loop | output nucleus for caudate nucleus |
| FEC.FT.SNC.LT | Substantia Nigra Pars Compacta Lateral | nucleus | FEU | executive loop | DP, dorsal circuits |
| FEC.FT.SNR.RM | Substantia Nigra Pars Reticulata Rostromedial | nucleus | FEU | Executive loop |
Internal Region Connections:
| Source Region | Target Region | Type | Reference |
| FEC.FD.STN.CD | FEC.FT.GPE.DS | nucleus-nucleus | (unknown reference) |
| FEC.FT.GPI.DS | nucleus-nucleus | Basal Ganglia Activity (STN -> GPi, abstract) | |
| FEC.FT.SNR.RM | nucleus-nucleus | (unknown reference) | |
| FEC.FT.CN.HD | FEC.FT.GPI.DS | nucleus-nucleus-gaba | Habenula Connections (CPu -> GPi, abstract) |
| FEC.FT.SNC.LT | nucleus-nucleus-gaba | Saccades and smooth movements (CN -> SN, abstract) | |
| FEC.FT.SNR.RM | nucleus-nucleus-gaba | Saccades and smooth movements (CN -> SN, abstract) | |
| FEC.FT.GPE.DS | FEC.FT.GPI.DS | nucleus-nucleus-gaba | (unknown reference) |
| FEC.FT.SNR.RM | nucleus-nucleus-gaba | Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract) | |
| FEC.FT.GPI.DS | FEC.FT.SNC.LT | nucleus-nucleus-gaba | Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract) |
| FEC.FT.SNR.RM | FEC.FT.SNC.LT | nucleus-nucleus-gaba | (unknown reference) |
External Inbound Region Connections:
| Source Area | Local Region | Source Region | Source Name | Type | Reference |
| Cortical | |||||
| NDM | FEC.FD.STN.CD | NDM.NC.AL.DACG | Dorsal Anterior Cingulate Area | neocortex-nucleus | (unknown reference) |
| FEC.FT.CN.HD | NDM.NC.AL.DACG | Dorsal Anterior Cingulate Area | neocortex-nucleus | Global visual system (FrontalCortex -> BGA, abstract) | |
| NDM.NC.AL.DLPFCL | Lateral Mid-Dorsolateral Prefrontal Cortex | neocortex-nucleus | Global visual system (FrontalCortex -> BGA, abstract) | ||
| Subcortical | |||||
| FAM | FEC.FT.SNC.LT | FAM.FD.LHB.MED | Lateral Habenula Medial Part | nucleus-nucleus | Habenula Connections (LHb -> SNc, abstract) |
| FEC | FEC.FT.SNC.LT | FEC.FT.SNR.DL | Substantia Nigra Pars Reticulata Dorsolateral | nucleus-nucleus-gaba | Oculomotor decision-making (SNr -> SNc) |
| FEC.HT.PPN.IPD | Interpeduncular Nucleus | nucleus-nucleus-ACh | Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> SNc, abstract) | ||
| LAC | FEC.FD.STN.CD | LAC.FD.HT.VM | Ventromedial Hypothalamic Nucleus | nucleus-nucleus | (unknown reference) |
| LRC | FEC.FT.SNC.LT | LRC.MM.SC.DEEP | Deep Superior Colliculus | nucleus-nucleus | Global visual system (SCi -> SNc, abstract) |
External Outbound Region Connections:
Motor Motivational Salience
| Component ID | Component Name | Type | Service | Function | Comments |
| FEC.FT.ACC.CORE | Nucleus Accumbens Core | nucleus | FEU | cognitive processing of motor function related to reward and reinforcement; encodes new motor programs which facilitate acquisition of given reward in future |
|
| FEC.FT.CN.TL | Caudate Nucleus Tail | nucleus | FEU | Successful classification learning, correct categorization | ITC, STC |
| FEC.FT.IPAC.LT | Lateral Interstitial Anterior Commissural Nucleus | nucleus | FAU | Striatal territory | innervates the pallidal complex, substantia nigra and retrorubral field |
| FEC.FT.PU.VT | Ventral Putamen | nucleus | FEU | Evaluation of flavors, taste, motivation loop | |
| FEC.FT.SNC.MED | Substantia Nigra Pars Compacta Medial | nucleus | FEU | motivational loop | VP, ventral circuits |
| FEC.FT.SNR.MED | Substantia Nigra Pars Reticulata Medial | nucleus | FEU | Motivational loop | |
| FEC.FT.VP.DL | Ventral Pallidum Dorsolateral | nucleus | FEU | motivational loop, NAcc-core | projects to STN, MD; circuit - VP-DL-rostral, DLPFC, NAcc-core-rostral, MD-rostral-lateral; circuit - VP-DL-caudal, DINS, NAcc-core-caudal, MD-caudal-medial |
Internal Region Connections:
| Source Region | Target Region | Type | Reference |
| FEC.FT.ACC.CORE | FEC.FT.SNC.MED | nucleus-nucleus-gaba | (unknown reference) |
| FEC.FT.SNR.MED | nucleus-nucleus-gaba | Craving (NACC -> SNr, abstract) | |
| FEC.FT.VP.DL | nucleus-nucleus-gaba | Craving (NACC -> VPAL, abstract) | |
| FEC.FT.CN.TL | FEC.FT.SNR.MED | nucleus-nucleus-gaba | Saccades and smooth movements (CN -> SN, abstract) |
| FEC.FT.PU.VT | FEC.FT.SNR.MED | nucleus-nucleus-gaba | (unknown reference) |
| FEC.FT.SNR.MED | FEC.FT.SNC.MED | nucleus-nucleus-gaba | (unknown reference) |
| FEC.FT.VP.DL | FEC.FT.SNR.MED | nucleus-nucleus-gaba | Craving (VPAL -> SNr, abstract) |
External Inbound Region Connections:
| Source Area | Local Region | Source Region | Source Name | Type | Reference |
| Cortical | |||||
| NDM | FEC.FT.ACC.CORE | NDM.NC.AL.FPC | Lateral Frontopolar Cortex | neocortex-nucleus | Affective basal ganglia circuit (OMPFC -> NACC, abstract) |
| FEC.FT.CN.TL | NDM.NC.AL.ROFCR | Most Rostral Orbitofrontal Cortex | neocortex-nucleus | Global visual system (FrontalCortex -> BGA, abstract) | |
| FEC.FT.PU.VT | NDM.NC.AL.VACG | Ventral Anterior Cingulate Area | neocortex-nucleus | Global visual system (FrontalCortex -> BGA, abstract) | |
| FEC.FT.SNR.MED | NDM.NC.AL.FPC | Lateral Frontopolar Cortex | neocortex-nucleus | Global visual system (FrontalCortex -> BGA, abstract) | |
| Subcortical | |||||
| FAM | FEC.FT.ACC.CORE | FAM.FD.TH.PT | Paratenial Nucleus of Thalamus | nucleus-nucleus | (unknown reference) |
| FAM.FT.AM.BP | Parvicellular Basal Amygdaloid Nucleus | nucleus-nucleus | Amygdala and its network (BLN -> NACC, abstract) | ||
| FEC.FT.CN.TL | FAM.FT.AM.AB | Accessory Basal Amygdaloid Nucleus | nucleus-nucleus | (unknown reference) | |
| FEC.FT.SNC.MED | FAM.FT.BNST | Bed Nucleus of Stria Terminalis | nucleus-nucleus | (unknown reference) | |
| FEC | FEC.FT.IPAC.LT | FEC.FT.ACC.SH | Nucleus Accumbens Shell | nucleus-nucleus-gaba | (unknown reference) |
| FEC.FT.PU.VT | FEC.FD.STN.DL | Subthalamic Nucleus Dorsolateral | nucleus-nucleus | (unknown reference) | |
| FEC.FT.SNC.MED | FEC.FT.GPI.RM | Globus Pallidus Internal Rostromedial | nucleus-nucleus-gaba | Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract) | |
| FEC.HT.PPN.RMTG | Rostromedial Tegmental Nucleus | nucleus-nucleus-gaba | Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> SNc, abstract) | ||
| FEC.FT.SNR.MED | FEC.FD.STN.DL | Subthalamic Nucleus Dorsolateral | nucleus-nucleus | (unknown reference) | |
| FEC.FT.GPE.RM | Globus Pallidus External Rostromedial | nucleus-nucleus-gaba | Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract) | ||
| FMM | FEC.FT.ACC.CORE | FMM.FD.TH.RH | Rhomboidal Nucleus of Thalamus | nucleus-nucleus | (unknown reference) |
| FMM.FT.HC.CA1D | Distal CA1 of Hippocampus | allocortex-nucleus | Nucleus Accumbens (CA1 -> NACC, abstract) | ||
| FMM.FT.HF.SUBD | Distal Subiculum | allocortex-nucleus | Nucleus Accumbens (SUB -> NACC, abstract) | ||
| FMM.FT.HF.SUBP | Proximal Subiculum | allocortex-nucleus | Nucleus Accumbens (SUB -> NACC, abstract) | ||
| FMM.NC.PH.LEC | Lateral Entorhinal Cortex | neocortex-nucleus | Nucleus Accumbens (EC -> NACC, abstract) | ||
| FMM.NC.PH.PAS | Parasubiculum | neocortex-nucleus | Nucleus Accumbens (PAS -> NACC, abstract) | ||
| FMM.NC.PH.PER | Perirhinal Cortex | neocortex-nucleus | Nucleus Accumbens (PRR -> NACC, abstract) | ||
| LMC | FEC.FT.SNC.MED | LMC.HT.LC | Locus Coeruleus | nucleus-nucleus-NE | (unknown reference) |
| LPC | FEC.FT.ACC.CORE | LPC.FD.TH.PV | Paraventricular Nucleus of Thalamus | nucleus-nucleus | (unknown reference) |
External Outbound Region Connections:
| Target Area | Local Region | Target Region | Target Name | Type | Reference |
| Cortical | |||||
| NMA | FEC.FT.SNR.MED | NMA.FD.TH.MDL | Lateral Mediodorsal Nucleus of Thalamus | nucleus-nucleus-gaba | Saccadic Vision (BG -> Thalamus, abstract) |
| FEC.FT.VP.DL | NMA.FD.TH.MDL | Lateral Mediodorsal Nucleus of Thalamus | nucleus-nucleus-gaba | Saccadic Vision (BG -> Thalamus, abstract) | |
| Subcortical | |||||
| FAM | FEC.FT.ACC.CORE | FAM.FD.LHB.LT | Lateral Habenula Lateral Part | nucleus-nucleus-gaba | Connectivity map of the habenula (NAc -> L, abstract) |
| FEC.FT.PU.VT | FAM.FT.EPF | Endopiriform Nucleus | nucleus-nucleus-gaba | Connectivity map of the habenula (CPu -> EP, abstract) | |
| FEC.FT.SNC.MED | FAM.FT.AM.CEM | Medial Central Amygdaloid Nucleus | nucleus-nucleus-DA | (unknown reference) | |
| FEC | FEC.FT.CN.TL | FEC.FT.GPI.RM | Globus Pallidus Internal Rostromedial | nucleus-nucleus-gaba | Habenula Connections (CPu -> GPi, abstract) |
| FEC.FT.IPAC.LT | FEC.FT.SNR.DL | Substantia Nigra Pars Reticulata Dorsolateral | nucleus-nucleus-gaba | (unknown reference) | |
| FEC.FT.VP.VM | Ventral Pallidum Ventromedial | nucleus-nucleus-gaba | (unknown reference) | ||
| FEC.FT.SNC.MED | FEC.FT.ACC.SH | Nucleus Accumbens Shell | nucleus-nucleus-DA | Connectivity map of the habenula (SNc -> CPu, abstract) | |
| FEC.FT.SNR.MED | FEC.HT.PPN.IPD | Interpeduncular Nucleus | nucleus-nucleus-gaba | (unknown reference) | |
| LAC | FEC.FT.SNC.MED | LAC.FD.HT.SUM | Supramammillary Nucleus | nucleus-nucleus-DA | (unknown reference) |
| LMC | FEC.FT.ACC.CORE | LMC.MM.VTA | Ventral Tegmental Area | nucleus-nucleus-gaba | Reward circuit of human brain (NACC -> VTA, abstract) |
| LRC | FEC.FT.SNC.MED | LRC.HT.PRF.PVR | Parvocellular Reticular Nucleus | nucleus-nucleus-DA | (unknown reference) |
Motor Extensor Loop
| Component ID | Component Name | Type | Service | Function | Comments |
| FEC.FD.STN.MED | Subthalamic Nucleus Medial | nucleus | FEU | Motor Extensor loop | |
| FEC.FD.TH.PF | Parafascicular Nucleus of Thalamus | nucleus | FEU | Stimulation of acetylcholine release in dorsal striata | Part of ascending activating system |
| FEC.FT.GPE.MED | Globus Pallidus External Medial | nucleus | FEU | Extensor loop | Body extensor movements, trunk and girdles |
| FEC.FT.GPI.MED | Globus Pallidus Internal Medial | nucleus | FEU | Motor extensor loop | indirect path |
| FEC.FT.PU.MED | Dorsal Putamen Medial | nucleus | FEU | Extensor motor initiation | dorsomedial, SMC and PMC - overlap, BA 6,46 |
| FEC.FT.SNR.DL | Substantia Nigra Pars Reticulata Dorsolateral | nucleus | FEU | Extensor motor loop, head |
Internal Region Connections:
| Source Region | Target Region | Type | Reference |
| FEC.FD.STN.MED | FEC.FT.GPE.MED | nucleus-nucleus | (unknown reference) |
| FEC.FT.GPI.MED | nucleus-nucleus | Basal Ganglia Activity (STN -> GPi, abstract) | |
| FEC.FT.SNR.DL | nucleus-nucleus | Saccadic Vision (STN -> SNpr, abstract) | |
| FEC.FD.TH.PF | FEC.FT.PU.MED | nucleus-nucleus | (unknown reference) |
| FEC.FT.GPE.MED | FEC.FT.GPI.MED | nucleus-nucleus-gaba | (unknown reference) |
| FEC.FT.SNR.DL | nucleus-nucleus-gaba | Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract) | |
| FEC.FT.GPI.MED | FEC.FD.TH.PF | nucleus-nucleus-gaba | Saccadic Vision (BG -> Thalamus, abstract) |
| FEC.FT.PU.MED | FEC.FT.GPE.MED | nucleus-nucleus-gaba | Basal Ganglia Activity (PU -> GPo, abstract) |
| FEC.FT.GPI.MED | nucleus-nucleus-gaba | Habenula Connections (CPu -> GPi, abstract) | |
| FEC.FT.SNR.DL | nucleus-nucleus-gaba | Global visual system (Striatum -> SNr, abstract) |
External Inbound Region Connections:
| Source Area | Local Region | Source Region | Source Name | Type | Reference |
| Cortical | |||||
| NMA | FEC.FD.STN.MED | NMA.NC.SMC.F6 | Pre-Supplementary Motor Area | neocortex-nucleus | (unknown reference) |
| FEC.FT.PU.MED | NMA.NC.PMC.F2 | Dorsal Caudal Premotor Cortex | neocortex-nucleus | Global visual system (FrontalCortex -> BGA, abstract) | |
| NMA.NC.PMC.F5 | Ventral Rostral Premotor Cortex | neocortex-nucleus | Primate Control of Grasping (F5 -> BG, abstract) | ||
| NMA.NC.SMC.F3 | Supplementary Motor Area | neocortex-nucleus | Global visual system (FrontalCortex -> BGA, abstract) | ||
| NMA.NC.SMC.F6 | Pre-Supplementary Motor Area | neocortex-nucleus | Primate Control of Grasping (F6 -> BG, abstract) | ||
| Subcortical | |||||
| FAM | FEC.FD.TH.PF | FAM.FT.SEP.MED | Medial Septal Nucleus | nucleus-nucleus-ACh | (unknown reference) |
| FEC | FEC.FT.GPE.MED | FEC.FT.CN.HD | Caudate Nucleus Head | nucleus-nucleus-gaba | Prefrontal Cortex (PFC) in motor behavior (CN.PU -> GP, abstract) |
| FEC.FT.PU.MED | FEC.FT.SNC.LT | Substantia Nigra Pars Compacta Lateral | nucleus-nucleus-DA | Connectivity map of the habenula (SNc -> CPu, abstract) | |
| FEC.FT.SNR.DL | FEC.FT.CN.BD | Caudate Nucleus Body | nucleus-nucleus-gaba | Global visual system (Striatum -> SNr, abstract) | |
| FEC.FT.IPAC.LT | Lateral Interstitial Anterior Commissural Nucleus | nucleus-nucleus-gaba | (unknown reference) |
External Outbound Region Connections:
| Target Area | Local Region | Target Region | Target Name | Type | Reference |
| Cortical | |||||
| NMA | FEC.FT.GPI.MED | NMA.FD.TH.VA | Ventral Anterior Nucleus | nucleus-nucleus-gaba | Thalamocortical relationships (sVA -> VA, abstract) |
| FEC.FT.SNR.DL | NMA.FD.TH.VA | Ventral Anterior Nucleus | nucleus-nucleus-gaba | Thalamocortical relationships (sVA -> VA, abstract) | |
| Subcortical | |||||
| FEC | FEC.FT.SNR.DL | FEC.FT.SNC.LT | Substantia Nigra Pars Compacta Lateral | nucleus-nucleus-gaba | Oculomotor decision-making (SNr -> SNc) |
| LRC | FEC.FT.SNR.DL | LRC.MM.SC.INT | Intermediate Superior Colliculus | nucleus-nucleus-gaba | Global visual system (SNr -> SCi, abstract) |
Motor Flexor Loop
| Component ID | Component Name | Type | Service | Function | Comments |
| FEC.FD.STN.LT | Subthalamic Nucleus Lateral | nucleus | FEU | Motor Flexor loop | |
| FEC.FD.TH.CM | Centromedian Nucleus of Thalamus | nucleus | FEU | Control of level of cortical activity | Lesions lead to persistent vegetative state |
| FEC.FD.TH.RIL | Rostral Intralaminar Nuclear Group of Thalamus | nucleus | FEU | cognitive functions | from SC LVII,LVIII/CR nuclei to striatum |
| FEC.FT.GPE.LT | Globus Pallidus External Lateral | nucleus | FEU | Flexor loop | |
| FEC.FT.GPI.LT | Globus Pallidus Internal Lateral | nucleus | FEU | Motor flexor loop | output nuclei of basal ganglia to neocortex, leg, arm, face; lateral - leg, medial - arm, ventral - face |
| FEC.FT.PU.LT | Dorsal Putamen Lateral | nucleus | FEU | Flexor motor initiation | ventrolateral, D1 receptor, MC and S1 - overlap, TH/CM from GPi; DL-leg, RL-face, VM-arms |
| FEC.HT.PPN.IPD | Interpeduncular Nucleus | nucleus | FEU | postural control, voluntary arm and eye movements | Pars compacta, anterior, compact subnucleus, ACh; unpaired |
| FEC.HT.PPN.RMTG | Rostromedial Tegmental Nucleus | nucleus | FEU | locomotion - walking, running | Pars dissipata, anterior, dissipated subnucleus, GABA; VTA tail |
Internal Region Connections:
| Source Region | Target Region | Type | Reference |
| FEC.FD.STN.LT | FEC.FT.GPE.LT | nucleus-nucleus | (unknown reference) |
| FEC.FT.GPI.LT | nucleus-nucleus | Basal Ganglia Activity (STN -> GPi, abstract) | |
| FEC.HT.PPN.RMTG | nucleus-nucleus | (unknown reference) | |
| FEC.FD.TH.CM | FEC.FT.PU.LT | nucleus-nucleus | Thalamocortical relationships (CM -> pCM, abstract) |
| FEC.FD.TH.RIL | FEC.FT.PU.LT | nucleus-nucleus | (unknown reference) |
| FEC.FT.GPE.LT | FEC.FT.GPI.LT | nucleus-nucleus-gaba | (unknown reference) |
| FEC.FT.GPI.LT | FEC.FD.TH.CM | nucleus-nucleus-gaba | Thalamocortical relationships (sCM -> CM, abstract) |
| FEC.FT.PU.LT | FEC.FT.GPI.LT | nucleus-nucleus-gaba | Habenula Connections (CPu -> GPi, abstract) |
| FEC.HT.PPN.IPD | FEC.FD.STN.LT | nucleus-nucleus-ACh | (unknown reference) |
| FEC.HT.PPN.RMTG | FEC.HT.PPN.IPD | nucleus-nucleus-gaba | (unknown reference) |
External Inbound Region Connections:
| Source Area | Local Region | Source Region | Source Name | Type | Reference |
| Cortical | |||||
| NMA | FEC.FD.STN.LT | NMA.NC.MC | Motor Cortex | neocortex-nucleus | (unknown reference) |
| FEC.FT.PU.LT | NMA.NC.MC | Motor Cortex | neocortex-nucleus | Basal Ganglia Activity (M1 -> PU, abstract) | |
| NSA | FEC.FT.PU.LT | NSA.NC.PG.S1 | Primary Somatosensory Cortex | neocortex-nucleus | Basal Ganglia Activity (S1 -> PU, abstract) |
| Subcortical | |||||
| FAM | FEC.HT.PPN.IPD | FAM.FD.MHB | Medial Habenula | nucleus-nucleus | Connectivity map of the habenula (M -> IPN) |
| FEC.HT.PPN.RMTG | FAM.FD.LHB.LT | Lateral Habenula Lateral Part | nucleus-nucleus | Both LHb and MHb control the dopaminergic and serotonergic systems (LHbL -> RMTg) | |
| FAM.FD.LHB.MED | Lateral Habenula Medial Part | nucleus-nucleus | Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> RMTg) | ||
| FEC | FEC.FT.PU.LT | FEC.FT.CN.BD | Caudate Nucleus Body | nucleus-nucleus-gaba | Regulation of Social Brain (Caud -> Put, abstract) |
| FEC.FT.SNC.LT | Substantia Nigra Pars Compacta Lateral | nucleus-nucleus-DA | Physiology and pathophysiology of lower urinary tract (SNC -> PU) | ||
| FEC.HT.PPN.IPD | FEC.FD.STN.ICD | Subthalamic Nucleus Internal Caudal | nucleus-nucleus | (unknown reference) | |
| FEC.FT.SNR.MED | Substantia Nigra Pars Reticulata Medial | nucleus-nucleus-gaba | (unknown reference) | ||
| FEC.HT.PPN.RMTG | FEC.FT.VP.VM | Ventral Pallidum Ventromedial | nucleus-nucleus-gaba | Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VPAL -> PPTG, abstract) | |
| LLC | FEC.FD.TH.CM | LLC.HT.CR.EN | Emboliform Nucleus | nucleus-nucleus | (unknown reference) |
| FEC.FD.TH.RIL | LLC.HT.CR.DN | Dentate Nucleus | nucleus-nucleus | (unknown reference) | |
| LLC.SC.IZ.CCV | Central Cervical Nucleus | nucleus-nucleus | (unknown reference) | ||
| LMC | FEC.HT.PPN.IPD | LMC.HT.TG.LDT | Laterodorsal Tegmental Nucleus | nucleus-nucleus-ACh | (unknown reference) |
External Outbound Region Connections:
Oculomotor and Auditory/Association Loop
| Component ID | Component Name | Type | Service | Function | Comments |
| FEC.FD.STN.ICD | Subthalamic Nucleus Internal Caudal | nucleus | FEU | Oculomotor loop | |
| FEC.FD.TH.LI | Limitans Nucleus of Thalamus | nucleus | LUS | Multisensory projection to striatum | From SC, trigeminal nucleus, superior and inferior colliculus |
| FEC.FT.CN.BD | Caudate Nucleus Body | nucleus | FEU | Oculomotor learning | FEF, SEF |
| FEC.FT.GPE.DL | Globus Pallidus External Dorsolateral | nucleus | FEU | Oculomotor loop | |
| FEC.FT.GPI.DL | Globus Pallidus Internal Dorsolateral | nucleus | FEU | Oculomotor loop | |
| FEC.FT.SNR.VL | Substantia Nigra Pars Reticulata Ventrolateral | nucleus | FEU | Oculomotor loop |
Internal Region Connections:
| Source Region | Target Region | Type | Reference |
| FEC.FD.STN.ICD | FEC.FT.GPE.DL | nucleus-nucleus | (unknown reference) |
| FEC.FT.GPI.DL | nucleus-nucleus | Basal Ganglia Activity (STN -> GPi, abstract) | |
| FEC.FT.SNR.VL | nucleus-nucleus | (unknown reference) | |
| FEC.FD.TH.LI | FEC.FT.CN.BD | nucleus-nucleus | (unknown reference) |
| FEC.FT.CN.BD | FEC.FT.GPI.DL | nucleus-nucleus-gaba | Habenula Connections (CPu -> GPi, abstract) |
| FEC.FT.SNR.VL | nucleus-nucleus-gaba | Saccades and smooth movements (CN -> SN, abstract) | |
| FEC.FT.GPE.DL | FEC.FT.GPI.DL | nucleus-nucleus-gaba | (unknown reference) |
External Inbound Region Connections:
| Source Area | Local Region | Source Region | Source Name | Type | Reference |
| Cortical | |||||
| NDM | FEC.FT.CN.BD | NDM.NC.AL.VACG | Ventral Anterior Cingulate Area | neocortex-nucleus | Global visual system (FrontalCortex -> BGA, abstract) |
| NMA | FEC.FT.CN.BD | NMA.NC.PMC.AFEF | Anterior Frontal Eye Field | neocortex-nucleus | Global visual system (FrontalCortex -> BGA, abstract) |
| NSA | FEC.FT.CN.BD | NSA.NC.IT.TE | Inferotemporal Cortex | neocortex-nucleus | (unknown reference) |
| NSA.NC.TTG.A2 | Auditory Association Area | neocortex-nucleus | (unknown reference) | ||
| Subcortical | |||||
| LMC | FEC.FD.STN.ICD | LMC.MM.RF.SUC | Superior Central Raphe Nucleus | nucleus-nucleus-5HT | (unknown reference) |
| LPC | FEC.FD.TH.LI | LPC.SC.PH.LMG | Lower Marginal Nucleus | nucleus-nucleus | (unknown reference) |
| LPC.SC.PH.UMG | Upper Marginal Nucleus | nucleus-nucleus | (unknown reference) | ||
| LRC | FEC.FD.STN.ICD | LRC.MM.PT.PTA | Anterior Pretectum Nucleus | nucleus-nucleus | (unknown reference) |
| FEC.FD.TH.LI | LRC.MM.SC.INT | Intermediate Superior Colliculus | nucleus-nucleus | Saccadic Vision (SCi -> Thalamus, abstract) |
External Outbound Region Connections:
| Target Area | Local Region | Target Region | Target Name | Type | Reference |
| Cortical | |||||
| NCP | FEC.FD.TH.LI | NCP.NC.INS.PPC | Peripaleocortical Claustral | nucleus-neocortex | Amygdalar disruption of prefrontal cortex (TH -> INS, abstract) |
| NDM | FEC.FD.TH.LI | NDM.NC.AL.DACG | Dorsal Anterior Cingulate Area | nucleus-neocortex | Saccadic Vision (Thalamus -> FrontalCortex, abstract) |
| NPE | FEC.FT.GPI.DL | NPE.FD.TH.LP | Lateral Posterior Nucleus of Thalamus | nucleus-nucleus-gaba | Saccadic Vision (BG -> Thalamus, abstract) |
| Subcortical | |||||
| FEC | FEC.FD.STN.ICD | FEC.HT.PPN.IPD | Interpeduncular Nucleus | nucleus-nucleus | (unknown reference) |
| FEC.FT.CN.BD | FEC.FT.PU.LT | Dorsal Putamen Lateral | nucleus-nucleus-gaba | Regulation of Social Brain (Caud -> Put, abstract) | |
| FEC.FT.SNR.DL | Substantia Nigra Pars Reticulata Dorsolateral | nucleus-nucleus-gaba | Global visual system (Striatum -> SNr, abstract) | ||
| LRC | FEC.FT.SNR.VL | LRC.MM.SC.INT | Intermediate Superior Colliculus | nucleus-nucleus-gaba | Saccadic Vision (BG -> SCi, abstract) |
Thirdparty Circuits
(generated)
- Saccadic Vision - see Reference
References
(generated)
- http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders
- http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html
- http://www.scholarpedia.org/article/Habenula
- http://www.springerimages.com/Images/LifeSciences/1-10.1007_s00359-004-0565-9-0
- http://www.sciencedirect.com/science/article/pii/S0959438808001566
- http://www.mdvu.org/library/disease/pd/par_path.asp
- http://journal.frontiersin.org/article/10.3389/fnhum.2013.00826/full
- http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin
- http://www.scholarpedia.org/article/Head_direction_cells
- http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html
- http://jn.physiology.org/content/107/10/2633
- http://rstb.royalsocietypublishing.org/content/364/1519/1005
- http://www.impulsecontroldisorders.org/html/cravings.html
- http://www.nature.com/nrn/journal/v5/n3/box/nrn1345_BX1.html
- http://learnmem.cshlp.org/content/18/6/384/F1.expansion.html
- http://what-when-how.com/neuroscience/the-thalamus-and-cerebral-cortex-integrative-systems-part-2/
